BioImaging Track (BIm)

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BioImaging Track (BIm)

• Track chairs
• E. Angelini , PhD (Telecom ParisTech)
• F. Cloppet , PhD (Univ. Paris Descartes)
• C. Oppenheim , MD (Univ. Paris Descartes)

http//www.bme-paris.org
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BME Master 2 BioImaging Track (BIM)
Bioimaging is an exciting field at the interface
between Mathematics, computer science, chemistry,
physics, life science, biology and medicine.
The main goal of Bioimaging is to improve human
health using imaging modalities to advance
diagnosis, treatment and prevention of human
disease.
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BME Master 2 BioImaging Track (BIM)
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Bio Imaging master track (BIM)
Basic sciences mathematics, physics, chemistry

• Complementary skills from
• University Paris Descartes,
• Paris Diderot
• Engineering schools of ParisTech
• BIM program
• Fifteen courses (UE) at the M2 level.
• Co-organized by faculty members experts in the
  field.

Applied mathematics signal image processing,
numerical analysis.
Biology and Medicine diagnostic tools,
innovative screening, contrast agents,
biomarkers, image-based modeling
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BioImaging Track Program
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BioImaging Track Program Program Content in
2010-2011

• Autumn Semester (30 ECTS)
• Interdisciplinary seminar (6 ECTS)
• Physics Technology of Medical Imaging (6 ECTS)
• Chemistry for Imaging (6 ECTS)
• Medical Image Analysis (6 ECTS)
• Molecular Imaging (3 ECTS)
• Functional Metabolism Imaging (3 ECTS)

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BioImaging Track Program Program Content in
2010-2011

• Spring Semester (30 ECTS)
• BioEngineering Economy and Industry (3 ECTS)
• BioEthics
• Research Internship five months (27 ECTS)

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Unit 3.5 Chemistry for Imaging

• Person(s) in charge
• Y.-M. FRAPART, O. CLEMENT, L. BINET
• Content
• Modern imaging, especially molecular and
  functional imaging using chemical contrast
  agents, and development from small animal
  imaging.
• Courses take place at
• Paris Descartes University

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Unit 3.5 Chemistry for Imaging

• Program
• Molecular probes and contrast agents for imaging
• Synthesis, functionalisation, vectorisation,
  metabolism
• Kinetics and pharmaco kinetics
• Agreement aspect, scaling up,
• Application in different modalities.
• State of the art of small animal imaging
  modalities and their applications
• MRI,CEST, DNP
• Computed Tomography,
• Ultra-sounds,
• Nuclear imaging,
• EPR imaging,
• Visit of the different platforms.

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Unit 3.5 Chemistry for Imaging

• Exam
• Quizz (2 hrs) (2/3 of evaluation)
• Plate-form visits with short report (1/3 of
  evaluation)
• Technical principle, applications, limitations,
  on one modality (10-20 p) per student.
• Visits can be organized in groups of three
  students.

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Unit 3.6 Physics and Technology of Medical
Imaging

• Person(s) in charge
• I. Peretti, C. De Bazelaire, E. Bossy
• Content
• Physics and technology of ultrasonic imaging,
  magnetic resonance imaging, nuclear medicine,
  X-ray imaging
• Courses take place at
• Paris Descartes University

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Unit 3.6 Physics and Technology of Medical
Imaging

• Program
• imaging with non-ionizing radiation
• ultrasonic imaging ultrasound physics, image
  reconstruction, transducer technology
• magnetic resonance imaging physical bases of
  NMR, conventional imaging sequences, chemical
  shift, high speed imaging, functional imaging
• imaging with ionizing radiation
• radiation physics,
• different types of X-ray detectors,
• X-ray computerized tomography
• nuclear tomographic imaging
• single photon emission computed tomography
• positron emission tomography

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Unit 3.6 Physics and Technology of Medical
Imaging

• Exam
• written exam (60 of evaluation)
• project (40 of evaluation)
• (oral or written at the second session)

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Unit 3.3 Medical Image Analysis

• Person(s) in charge
• E. Decenciere, F. Cloppet
• Content
• Main objective to provide the students with the
  means to understand and use the most common tools
  in bio-medical image analysis
• Theoretical courses and practical training
  sessions
• Project with PhD students in biomedical image
  processing
• Courses take place at Telecom ParisTech

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Unit 3.3 Medical Image Analysis

• Main topics
• Foundations of image processing
• Linear image processing
• Morphological image processing
• Segmentation
• Quantification and shape characterization
• Beyond the second dimension 3D image and
  temporal sequences
• Exam
• Written test (40 of evaluation)
• Project (30)
• Practical sessions (30)

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Unit 3.9a Molecular Imaging

• Person(s) in charge
• C.A. Cuenod, D. Leguludec
• Content
• Description of the growing field of molecular
  imaging.
• Description of specific targets for molecular
  imaging and the way visualize them.
• The targets will be illustrated in the context of
  a specific medical field and when applicable to
  therapeutic implications.

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Unit 3.9a Molecular Imaging

• Program
• Definition of molecular imaging.
• Membrane, cellular metabolism and intercellular
  interactions,
• Value of molecular imaging in biology and
  medicine,
• In vivo maging modalities and multimodal imaging
• Receptor imaging (Applications in neurology)
• Anti-bodies and membrane motifs (Applications in
  oncology)
• Cellular metabolism, trans-membrane transport and
  viability (Applications in cardiology)
• Non-membranous motifs and enzyme targets
  (Applications in liver fibrosis and arterial
  thrombosis)
• Cell Migration and tissue (re)generation, Cell
  therapy,
• Imaging of macrophagic cells
• Drugs tagging , evaluation of therapeutic effects

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Unit 3.9a Molecular Imaging

• Courses take place at
• Paris Descartes University
• Exam
• Writing answers to 3 to 4 questions regarding the
  course content.

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Unit 3.10a Functional Metabolism Imaging

• N. Boddaert, B. Van Beers
• Brain imaging, N Boddaert
• 8h30-10h30. C Poupon (Neurospin)
• Diffusion-weighted magnetic resonance imaging.
• The diffusion process in biological tissues.
  Diffusion sensitization of
• MRI data. Local modeling of the diffusion
  process case of the
• Diffusion Tensor, model and tractography,
  anatomical connectivity
• and applications.
• 10h30-11h30. P Ciuciu (Neurospin)
• Functional imaging
• 12h00-13h00. JC Baron (Cambridge)
• TEP and MRI from theory to clinical
  applications.
• LUNCH BREAK OFFERED AT SAINTE-ANNE Hospital
• 14h30-15h30 N Boddaert/ M Zilbovicius (Necker).
• Clinical application. Anatomical and functional
  imaging in autism

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Unit 3.10a Functional Metabolism Imaging

• Course 8h30 10h30
• Fast and diffusion-weighted MR imaging. Ralph
  Sinkus (08h30 09h30)
• Principles and trade-offs of fast imaging for
  quantitative applications.
• Single and multi-exponential analysis of
  diffusion-weighted MR imaging.
• Perfusion imaging. Charles-André Cuénod (09h30
  10h30)
• Dynamic contrast enhanced imaging for perfusion
  quantification
• Course 11h00 13h00
• Elastography. Ralph Sinkus
• Principles of static and dynamic elastography.
• Ultrasound and MR elastography.
• Analysis of elastography, viscosity, and
  multi-frequency parameters.
• Course 14h15 16h00
• Perfusion imaging and fat quantification. Bernard
  Van Beers
• Applications of quantitative perfusion imaging in
  liver diseases and abdominal tumors.
• Methods and applications of fat quantification.
• Diffusion-weighted MR imaging. Bernard Van Beers
• Value and limitations of diffusion-weighted MR
  imaging in liver diseases and abdominal tumors
• Course 16h20 18h00
• Elastography. Bernard Van Beers

Biomedical Engineering Master BioImaging Track
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Unit 3.10a Functional Metabolism Imaging

• Courses take place at
• 29 November 2010  at St Anne Hospital
• 9 December 2010 at Paris Descartes
• Exam
• Writing exam 2 hours.
• Multiple choices questions

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BIM Research Labs

• Image Processing Labs
• Telecom ParisTech Medical image processing group
• Paris Descartes UFR Mathematics-Computer
  Sciences
• Mines ParisTech Biological image processing
• Radiology Labs
• Hospitals Ste Anne, HEGP, Lariboisière,.
• PARCC Paris Cardiovascular Center of Research
• Biological Imaging Labs
• Animal imaging platform Microscopy, Spectroscopy
  via Electronic Paramagnetic Resonance,
• Institut dOptique Graduate School ParisTech
• ENSTA ParisTech Laser-tissue interactions
• ESPCI novel elastography ultrasound imaging
• Chemistry Labs
• Chimie ParisTech
• University Paris Descartes

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BIM after the M2.

• RD engineer
• Main industrials of whole body screening GE,
  Philips, Siemens
• Startups in medical imaging Supersonic,
  Echosens,
• Biological imaging Biospace Lab, Leica,
• Pharmaceutical companies Sanofi Aventis,
  Guerbet,
• Medical Imaging Software Dosisoft,
• Additional Loreal,.
• PhD student
• Medical image processing
• Medical imaging
• Biological imaging