2nd Programmatic Meeting

1
2nd Programmatic Meeting

• Scientific Working Group
• June 13 14, 2005
• Blacksburg, VA

2

• a Scientific Working Group has been created for
  the PRCs and is being coordinated through the
  Administrative Center. Based on the state of
  proteomic, technological and research advances,
  the group will provide advice to the PRCs and
  the Administrative Center on current operations
  and future directions. (http//www.niaid.nih.gov/
  dmid/genomes/prc/administrative.htm)

3

• A more complete definition
• The Proteomic Research Centers and
  Administrative Resource Center will solicit
  advice from the SWG on all aspects of the
  operations and future directions of the PRC
  sites including policies and practices for data,
  reagent, and technology sharing among the sites
  and with the broader research community.

4

• Selection process
• Names of investigators were solicited from the
  Administrative Center and all seven Proteomics
  Research Centers (PRCs)
• Program staff additions created a pool of over 30
  investigator/candidates
• Selections made to create a group with balance
  between the areas of Proteomics, Bioinformatics
  and Biodefense research

5

• Jonas S. Almeida, Ph.D.
• Associate Professor of Bioinformatics, Department
  of Biostatistics, Bioinformatics
  Epidemiology,Medical University of South
  Carolina
• Expertise in Bioinformatics
• Research Focus Study of Systems Biology by
  identification of data-driven hypothesis-generatin
  g mathematical modeling. In particular, machine
  learning by artificial neural networks for
  dynamic modeling and biomarker discovery

6

• Abdu Azad, Ph.D., M.P.H.
• Professor Department of Microbiology and
  Immunology, University of Maryland School of
  Medicine
• Expertise in Proteomics
• Research Focus molecular basis of rickettsial
  pathogenesis - Rickettsia typhi, R. prowazekii,
  and R. rickettsii biology and immunology of
  malaria parasite liver-stages, identify
  Plasmodium genes in the infected hepatocytes,
  which are expressed early after infection, and
  shut off during the blood-stage cycle

7

• Trisha N. Davis, Ph.D.
• Professor, Department of Biochemistry, University
  of Washington1988 Searle Scholar
• Expertise in Proteomics
• Research Focus Centrosome and spindle pole body
  (SPB) regulation, ultrastructure and function
  core SPB proteins of Saccharomyces cerevisiae

8

• Thomas W. Geisbert, Ph.D
• Chief of the Department of Viral Pathology
  Ultrastructure, Virology Division, USAMRIID, Fort
  Detrick, Maryland
• Expertise in Biodefense
• Research Focus Pathogenesis and Immunology of
  Hemorrhagic Fever Viruses

9

• David S. Roos, Ph.D.
• Merriam Professor of Biology, Director, Genomics
  Institute, University of Pennsylvania
• Expertise in Bioinformatics
• Research Focus cell biology and molecular
  genetics of protozoan parasitesToxoplasma and
  Plasmodium (malaria) eukaryotic evolution
  designing and mining genome databases
  computational biology

10

• R. Reid Townsend, M.D., Ph.D.
• Director, Alvin J. Siteman Cancer Center
  Proteomics Core, Associate Professor of Medicine,
  Division of Endocrinology, Washington University
  School of Medicine
• Expertise in Proteomics
• Research Focus The identification of cancer
  biomarkers and novel drug targets membrane
  proteomics - localizing and defining the dynamics
  and differences of protein cohorts in subcellular
  membranes and organelles from cancer cells
  disease-associated protein markers

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• Paula Traktman, Ph.D.
• Walter Schroeder Professor and Chair,
  Microbiology and Molecular Genetics Department,
  Medical College of Wisconsin
• Expertise in Biodefense
• Research focus Kinases, phosphotases and
  polymerases vaccinia virus and its interaction
  w/ the host

12

• All SWG members were mailed a packet with
  background information
• The group will be meeting via conference call
  quarterly for updates and as needed
• As mentioned before, their role will be advisory
  
• We are glad to have them on board and look
  forward to working with them