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Synthetic Liver Lesion Models

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In vivo testing with live animals; use of hospital facility. Budget $300 ($450) Total ... Wavelet-packet-based texture analysis for differentiation between benign and ... – PowerPoint PPT presentation

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Title: Synthetic Liver Lesion Models


1
Synthetic Liver Lesion Models
  • Group Members Peng Ying, Ronghua Yang, Bin Luo
  • Mentors Dr. Michael Awad, Dr. Michael Choti,
  • Dr. Russel H. Taylor
  • Affiliates Joshua Leven, Emad Boctor

2
Background
  • 1 million cases of primary liver cancer per year
    detected worldwide
  • Epidemic of Hepatitis C is expected to increase
    liver tumor prevalence
  • 5 year survival rate is less than 10

3
Typical Stage I Tumor- localized- no greater
than 2 cm
Ultrasound Image
  • Stage I IV

4
Current Procedure
  • Radiofrequency Ablation
  • Cryosurgery
  • Surgical resection
  • Liver transplant
  • Intra-arterial Infusion Pump

5
RF Ablation in Detail
After RF Ablation No continued uptake of
contrasting material
Before RF Ablation - Takes up contrast material,
white on CT scan
Images from Massachusetts General Hospital
website
6
Current Research
  • Joshua Leven microultrasound surgical probe
  • Emad Boctor 3D elastography

7
Project Description
  • Create liver lesion
  • Various size
  • Various density/elasticity
  • Visibility by Ultrasound/X-ray
  • Ability to introduce needle within lesion
  • Devise minimally invasive methods to implant
    synthetic lesions both in vivo and in vitro
  • Construct a phantom liver model

8
Models in Development
  • Marble
  • unable to introduce needle
  • Agro gel
  • cant mimic all visibility conditions
  • Balloon Catheter (in vitro)
  • premature solidification of agro gel
  • Other concerns
  • shape consistency, implantable

9
Deliverables
  • Minimal
  • Reusable spherical molds of various sizes
  • Expected
  • Model different types of echogenicity
  • Model a range of elasticity
  • Maximum
  • Protocol of creating realistic in vivo lesions
  • Phantom liver model

10
Dependencies
  • BME machine shop for constructing the spherical
    molds
  • Ultrasound devices at the Hopkins Medical School
    and Homewood campus
  • In vivo testing with live animals use of
    hospital facility

11
Budget
12
Timeline
13
Project Management
14
References
  • Moug SJ, Horgan PG, Leen E
  • Contrast-enhanced ultrasonography during liver
    surgery (Br J Surg 2004 91 1165-1167).Br J
    Surg. 2005 Jan92(1)121-2
  • Solbaiti L, Tonolini M, Cova L, Goldberg SN.
  • The role of contrast-enhanced ultrasound in the
    detection of focal liver leasions.Eur Radiol.
    200111 Suppl 3E15-26.
  • Yoshida H, Casalino D, Keserci B
  • Wavelet-packet-based texture analysis for
    differentiation between benign and malignant
    liver tumors in ultrasound images
  • 2003 Phys. Med. Biol. 48
  • Dr. Michael Awads grant purposal
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