Week 8: Infectious Changes

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Week 8 Infectious Changes

• Stem cell theory
• Interleukins
• Neutrophilia
• Monocytosis
• Neutropenia
• Leukoerythroblastic rxn
• Shift to the left
• MGP and CGP
• Toxic changes
• LAP

• Lymphocytosis
• Reactive lymphocyte
• Turk cell
• Plasma cell
• Immunoblast
• IM (EBV)
• Protein ELP
• Eosinophilia
• Basophilia

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Leukocyte Development

• Stem cell theory
• Proliferation
• Differentiation
• Maturation
• Leukocyte precursors

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Bacterial infection

• Neutrophilia with shift to the left
• Toxic changes
• Leukoerythroblastic reaction
• Monocytosis with chronic infection (eg, TB)
• Neutropenia with overwhelming infection
• High LAP score

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Leukocytosis
Shift to the Left
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Neutrophilia

• Mobilization of cells in the marginal granulocyte
  pool (MGP) to circulating granulocyte pool (CGP)
• Bone marrow activity leads to leukemoid reaction

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Toxic Changes

• Toxic granulations 1o granules persisting to the
  older stages
• Dohle bodies RNA
• Vacuoles, not related to storage in EDTA

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Toxic Changes in Neutrophils
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Viral Infection

• Lymphocytosis
• Beware of pediatric reference ranges
• Distinguish from CLL
• Reactive lymphocytes (ATL, virocytes)
• Downey classes and Turk cell
• Immunoblast
• EBV associated with IM do serology
• Broad g increase in protein ELP

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Lymphocytosis and Reactive Lymphocytes
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Serum Protein Electrophoresis
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Parasitic Infection and Allergy

• Eosinophilia in parasitic infection
• Eosinophilia and basophilia in allergy
• Note basophilia in CML