Characterization of delivery systems for nanomedicine

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Characterization of delivery systems for
nanomedicine Dr. John A. Dagata
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Benefits and advantages of nanomedicine

• Targeted nanoparticle delivery systems
• One of the most promising nanomedicine platforms
• Use an engineered virus-like particle to direct
  therapeutics diagnostics only to cancer cells
• Lower dosage
• Reduced costs side effects

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• NIST-NCI-FDA Alliance
• Impact of healthcare costs on the US economy
• Protocols and standards for faster move into
  clinical trials
• CNPlan (NCI 2004)
• Critical Path Initiative (FDA 2004)

Technology Methodologies for nonspecific
adhesion of bio-nanoparticles to surfaces for
high-magnification imaging and characterization
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• Commercial Applications
• Drug discovery and development
• Quality assurance (manufacturability and potency)
• Environmental health safety

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Drug discovery and development
(collaboration with Esther Chang, Georgetown
University Medical Center)
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• Metrology of soft material
• Small sample volume (10 ?L)
• Adjustment of solution properties (essential for
  actual drug formulations)
• Fluid scanning probe microscopy of intact
  liposomes
• Non-optical statistical size distribution and
  zeta potential

SPM tip
tip probing liposome
tip probing SPIO
SPIO NDS
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Collaboration Opportunities CRADA SBIR For
technical details see the posters Physical
characterization of liposome-based targeted
nanoparticle delivery systems with encapsulated
MRI contrast agents Imaging, characterization,
and manipulation of nanobioparticles Fluid
scanning probe and surface zeta potential
measurements of targeted delivery systems N.
Farkas, et al.
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Contact Information John A. Dagata Precision
Engineering Division Manufacturing Engineering
Laboratory National Institute of Standards
Technology 100 Bureau Drive MS 8212 Gaithersburg
MD 20899-8212 301-975-3597 tel. [phone]
fax john.dagata_at_nist.gov