Aptes Particles

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Multistage System Loading Time Course
Oxidized Particles
Amino Q-dots
Aptes Particles
Carboxyl Q-dots
Aptes
Oxidized
PEG-FITC-SWNT
Oxidized Particles
Nanoliposomes
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Multiple loading of silicon particles
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Nature Nanotechnology March 2008
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References
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ResearchDevelopmentDeployment

• Models and Experiences of Partnerships

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Some nanotech research programs in the developing
world

• India's Department of Science and Technology
  Nanomaterials Science and Technology Initiative,
  2004-2009, 20 million
• Panacea Biotec (New Delhi, India) drug delivery
  research using mucoadhesive nanoparticles
  (vaccines via nasal swabs?)
• Dabur Research Foundation (Ghaziabad, India)
  Phase-1 clinical trials of nanoparticle delivery
  of the anti-cancer drug paclitaxel.
• The number of nanotechnology patent applications
  from China ranks third in the world behind the
  United States and Japan.
• Brazil Three institutes, four networks, and
  approximately 300 nanotech 20042007 funding at
  25 M
• South African Nanotechnology Initiative is a
  national network of academic researchers
  (nanophase catalysts, nanofiltration, nanowires,
  nanotubes, and quantum dots)
• Nanotechnology programs in Thailand, the
  Philippines, Chile, Argentina, Mexico, etc.

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Nanotech and Global Health GEM4

• Global Enterprise for Micro-Mechanics and
  Molecular Medicine (10/12/2005 Subra Suresh,
  convener).
• Focus using tools like atomic force microscopes,
  laser tweezers, and nanoscale plate stretchers --
  staples at Suresh's three-year-old
  Nano-Mechanical Technology Lab at MIT -- to study
  changes in human cells for research projects on
  infectious diseases like malaria and sickle cell
  anemia, cancers of the liver and pancreas, and
  cardiovascular diseases.
• Collaborators National University of Singapore
  Institut Pasteur of France, .Harvard School of
  Public Health, the Max-Planck Institute in
  Germany, the University of Illinois, Georgia
  Institute of Technology, California Institute of
  Technology, Johns Hopkins University, and
  Chulabhorn Research Institute in Thailand.

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Alliance for NanoHealth, Houston TX(est. by Rick
Smalley Trip Casscells)

• Consortium of eight institutions, 12/16/2004
• Virtual collection of 500 investigators ( 50
  ANH funded)
• Mechanism for funding
• Shared infrastructure
• Collaborative research (seed funds centers)
• Conferences/workshops
• Student programs

Office The Fayez S. Sarofim Research Building
(IMM) 537 at UTHSC-H.
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NCI Nanotechnology Alliance 144 (Launched
September 2005)

• Major Programs of the Alliance

• Centers of Cancer Nanotechnology Excellence
• Multidisciplinary Research Teams
• Training
• Interagency Collaborations
• Nanotechnology Platforms for Cancer Research
• Nanotechnology Characterization Laboratory

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NCI Nanotechnology Alliance - Awards
Nanotechnology Platform for Pediatric Brain
Cancer Imaging and Therapy, University of
Washington, Seattle, Wash.
Integrated System for Cancer Biomarker Detection,
Massachusetts Institute of Technology, Cambridge,
Mass.
Novel Cancer Nanotechnology Platforms for
Photodynamic Therapy and Imaging, Roswell Park
Cancer Institute, Buffalo, N.Y. Multifunctional
Nanoparticles in Diagnosis and Therapy of
Pancreatic Cancer, State University of New York,
Buffalo, N.Y.
MIT-Harvard Center of Cancer Nanotechnology
Excellence, Cambridge, Mass.
DNA-linked Dendrimer Nanoparticle Systems for
Cancer Diagnosis and Treatment, University of
Michigan, Ann Arbor, Mich.
Detecting Cancer Early with Targeted Nano-probes
for Vascular Signatures, University of
California, San Francisco, Calif.
Nanotherapeutic Strategy for Multidrug Resistant
Tumors, Northeastern University, Boston, Mass.
Photodestruction of Ovarian Cancer ErbB3
Targeted Aptamer-Nanoparticle Conjugate,
Massachusetts General Hospital, Boston, Mass.
Nanomaterials for Cancer Diagnostics and
Therapeutics, Northwestern University, Evanston,
Ill.
Metallofullerene Nanoplatform for Imaging and
Treating Infiltrative Tumor, Virginia
Commonwealth University, Richmond, Va.
Hybrid Nanoparticles in Imaging and Therapy of
Prostate Cancer, University of Missouri,
Columbia, Mo.
Center for Cancer Nanotechnology Excellence
Focused on Therapy Response, Stanford University,
Palo Alto, Calif.
Nanosystems Biology Cancer Center, California
Institute of Technology, Pasadena, Calif.
The Siteman Center of Cancer Nanotechnology
Excellence at Washington University, St. Louis,
Mo.
Center of Nanotechnology for Treatment,
Understanding, and Monitoring of Cancer,
University of California, San Diego, Calif.
Carolina Center of Cancer Nanotechnology
Excellence, University of North Carolina, Chapel
Hill, N.C.
Near-Infrared Fluorescence Nanoparticles for
Targeted Optical ImagingUniversity of Texas M.
D. Anderson Cancer Center, Houston, Texas
Emory-Georgia Tech Nanotech-nology Center for
Personalized and Predictive Oncology, Atlanta, Ga.
Nanotechnology Platform for Targeting Solid
Tumors, The Sidney Kimmel Cancer Center, San
Diego, Calif.
Centers of Cancer Nanotechnology Excellence
(8) Cancer Nanotechnology Platform Partnerships
(12)
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• Our Nanomedicine Group

Director Mauro Ferrari Full Professor Fredi
Robertson (MDACC) Associate Professor Paolo
Decuzzi Vittorio Cristini (SHIS
UTHSC) Assistant Professors Mark Cheng, XueWu
Liu, Takemi Tanaka Visiting Scholars Profs. M.
Kojic (Harvard), F. Hussain (U Houston) PostDocs
Ennio Tasciotti, Rohan Bhavane, Rita Serda, Dan
Fine, Ali Boumrani, James Gu, Biana
Godin-Vilentchouk, Enrica De Rosa, Victor Calo
Students Alessandro Grattoni, Tony Hu, Kevin
Plant, Zongxing Wang, Silvia Ferrati, Ciro
Chiappini, Francesco Gentile, SiSi Yuang Research
Staff Amber Jimenez, Li Li, Jean Farkhouri,
Kathy Veer Advocacy Director D.
Johnson Executives Jason Sakamoto (ANH), Tong
Sun (BME) Administration Dee Fegans, Ramona
Thomas, Victoria Herrera, Viju Bha Spin-offs/Discl
osures Leonardo, NanoMedical Systems
(NMS) Arrowhead Research Corporation
(NASDAQARWR) Director of Scientific
Strategy Funding NCI, NIH, NASA, DARPA, TATRC,
State of Texas, UTHSC, NMS
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Thanks!

• Mauro.Ferrari_at_uth.tmc.edu