CIHRs 13 Institutes

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CIHRs 13 Institutes
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Four Research Pillars of CIHR

• Biomedical
• Clinical
• Health services and health systems
• Health of populations, societal and cultural
  dimensions of health, and environmental
  influences on health

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CIHR Budget 2005-2006
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Canadian Institutes of Health Research
Institute of Neurosciences, Mental Health and
Addiction
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CIHR-INMHA a Canadian Experiment

• Virtual institute aimed to promoting
• interdisciplinary approaches to the study of
  neuroscience, mental health, addictions and the
  sensory systems
• integration of neuroscience (including vision,
  hearing, communication, pain, etc.), mental
  health and addiction research
• Unique model in the world
• Quirion (2002) A Canadian experiment INMHA. How
  to link up the brain via a virtual institute.
  TINS 25 268-270

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Institute Advisory Board 2004-2005

• Dr. Anthony Phillips (Chair)
• Dr. Kathryn Bennett
• Dr. Serge Brochu
• Dr. Yves de Koninck
• Ms. Judy Hills
• Dr. Judy Illes
• Mrs. Mary Jardine
• Dr. Alain Lesage (vice-chair)
• Dr. Ravi Menon
• Dr. Freda Miller
• Dr. Marlene Reimer
• Dr. Patrice Roy
• Dr. Michael Salter
• Dr. Eric Single
• Dr. Martin Steinbach
• Dr. Jane Stewart
• Dr. Donald Weaver
• Dr. Douglas Zochodne

• University of British Columbia, Vancouver BC
• McMaster University, Hamilton ON
• Université de Montréal, Montreal (Quebec)
• Université Laval, Quebec City (Québec)
• Public Representative, Toronto ON
• Stanford University, Palo Alto CA
• Public Representative, Toronte ON
• Université de Montréal, Montréal QC
• University of Western Ontario, London ON
• University of Toronto, Toronto ON
• University of Manitoba, Winnipeg MB
• Pfizer Canada, Montréal QC
• University of Toronto, Toronto ON
• University of Toronto, Toronto ON
• York University, Toronto ON
• Concordia University, Montréal QC
• Dalhousie University, Halifax NS
• University of Calgary, Calgary AB

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INMHA IAB Focus Groups

• Ethics and Law
• Government Affairs and Networking
• Industry and biotechnology
• International Affairs
• Performance Evaluation and Budget
• Training and Education
• Voluntary Sector and Professional Organizations
• Clinical Research

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INMHA Vision

• The Institute of Neurosciences, Mental Health
  and Addiction believes that innovative, ethically
  responsible research will lead to better health
  for all Canadians.

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INMHA Mission

• The mission of the INMHA is
• to foster excellence in innovative, ethically
  responsible research that increases our knowledge
  of the functioning and disorders of the brain and
  the mind, the spinal cord, the sensory and motor
  systems, and mental health, mental illness and
  all forms of addictions.
• To foster cutting-edge research that incorporate
  the four pillars of CIHR biomedical, clinical,
  health services and health systems, and
  population health
• to translate this new knowledge into improved
  health outcomes and quality of life for all
  Canadians.

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INMHA Values

• INMHA
• Commits to the support of excellence, scientific
  integrity and ethics in research that meets the
  highest international standards
• Cultivates an understanding of the diversity of
  the disciplines covered by the INMHA mandate in
  order to expand beyond traditional approaches to
  research
• Affirms the importance of research and knowledge
  translation as means of making a difference in
  the lives of people who are experiencing or who
  are at risk for the disorders and illnesses of
  concern to the INMHA

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INMHA Values

• INMHA
• Respects ethical, transparent and effective
  governance and management processes that
  establish the INMHAs credibility and strengthen
  its organizational capacity
• Acknowledges its accountability to the Governing
  Council of the CIHR, the Government of Canada and
  Canadians for the accomplishment of its mission.

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INMHA Strategic Goals

• To accomplish its mission, the INMHA will
• Promote and support excellence in peer-reviewed,
  internationally recognized and ethically
  responsible research in the domains of the
  Institute, including co-occurrence with other
  health problems and co-morbidity
• Encourage trans-disciplinary research in order to
  facilitate knowledge transfer aimed at developing
  and improving health care treatments and
  services
• Ensure the training and support of the next
  generation of Canadian scientists in all aspects
  of neurosciences, mental health, and addiction by
  promoting and sustaining the development of
  trans-disciplinary programs of research and
  training.

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INMHA Strategic Goals

• To accomplish its mission, the INMHA will
• Work with non governmental and volunteer health
  organizations, municipal governments and other
  interested stakeholders to reduce the
  discrimination and prejudices associated with
  neurological and sensory disorders, mental
  illnesses and addictions
• Promote the visibility and mandate of the INMHA
  and its contribution through effective
  communication with all sectors of civil society

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INMHA Strategic Goals

• To accomplish its mission, the INMHA will
• Work with the Government of Canada, provincial
  and territorial governments, members of the
  scientific community, non governmental and
  volunteer health organizations, foundations and
  all Canadians to ensure that sufficient human and
  financial resources, consistent with the burden
  of disease of the disorders covered by the INMHA,
  are made available to the Institute in order to
  enable it to achieve its goals.
• Interact with all stakeholders to identify
  research priorities, establish partnerships and
  undertake collaborative activities.

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Approaches Used to DevelopINMHA First Strategic
Plan

• Visits to universities and research centres
  across the country (gt30)
• Two NGO meetings
• http//www.cihr-irsc.gc.ca/e/8586.html
• International visits
• NIH, WHO, PAHO, etc.
• Prioritization by IAB and Scientific Director
• 2001-2005 Strategic Plan

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Outcomes of consultations
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INMHA Strategic Priority One

• To foster and develop a capacity for innovation
  in research in neurosciences, mental health and
  addiction
• Training
• Strategic Initiatives
• Early Life Events and First episodes in brain
  disorders
• Co-occurrence of brain disorders with other
  health problems and co-morbidity
• Regenerative Medicine and Nanonmedicine
• Nicotine addiction and tobacco abuse
• Emerging areas and unique opportunities
• Research in bioethics

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INMHA Strategic Priority Two

• To pursue and sustain collaborative partnership
• The INMHA will
• Collaborate with the Strategic Partnerships and
  Alliances and the Industry Program Branches of
  CIHR in identifying and developing potential
  partnerships
• Develop sustainable partnerships with other
  Institutes and with governmental organizations at
  the national and international levels as well as
  with NGOs and VHOs
• Collaborate and partner with NGOs and VHOs in
  effort aimed at advancing
• Advocacy, information dissemination, knowledge
  translation, training, leverage funding,
  surveillance, community support

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INMHA Strategic Priority Three

• To promote linkage and exchange through
  structured efferts aimed at knowledge translation
• The INMHA has defined the following strategies
• Collaborate with CIHR in developing a framework
  for contributing to public policies and programs
  that will help create an environment conducive to
  the development of the CIHR and its institutes
• Engage in structured, individual activities that
  promote linkage and exchange
• Develop a comprehensive stakeholder knowledge
  translation strategy

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INMHA Strategic Priority Four

• To insure INMHAs presence on the international
  stage
• The INMHA will help Canadian scientists by
  promoting and developing joint research and
  training initiatives with institutes in other
  countries. This strategy will enable the INMHA
  to
• Develop and pursue collaborations international
  research projects and funding
• Promote and establish trainee exchange programs
  at the international level.

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INMHA Strategic Priority Five

• To establish an effective organizational and
  operational structure
• The INMHAs organizational structure and
  operational processes must support the efforts
  and endeavours of the Institute, and ensure its
  accountability to CIHR and its stakeholders.
  Three components of the strategy have been
  identified
• Implement an effective governance, accountability
  and management structure and process
• Develop and sustain structured communication
  efforts aimed at informing and gaining an
  understanding of the health and research issues
  related to INMHAs domains
• Develop a framework for gathering, maintaining
  and accessing relevant and reliable health and
  research information in the fields of interest to
  the INMHA.

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INMHA Institute Support Grant

• 1 million/year since 2001
• Staff salaries
• Conference, symposia and workshops
• Annual Meeting
• Annual reports and brochures
• Web site (www.thebrain.mcgill.ca)
• IAB expenditures
• Travel
• Office rental
• Supplies
• International Activities
• Partnership Development

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INMHA Strategic Initiative Budget
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INMHA Strategic Initiative Budget 2004-2005
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Some INMHA initiatives (2002-2005)

• Brain Star Award
• Strategic Training Initiative in Health Research
• Bridging Operating Grants
• Priority announcement
• New Emerging Team Program
• Strategic Initiatives
• Inter-institute partnerships
• International Collaborations
• Workshops and scientific meetings

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INMHA Strategic Priority One

• Training Grants and
• Salary Support

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Brain Star Program

• To recognize the excellence of research done by
  trainees in all fields covered by our Institute
• 1,000 per award
• Awarded every 2 weeks
• Based on a research article recently published as
  first author in a high impact journal
• Cross-pillar is a plus
• Brain Star of the year since 2003
• For more details
• www.cihr-irsc.gc.ca/e/8585.html

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Recent Brain Star Awardees

• McMaster (Dalhousie) Hippocampal volume in early
  onset of depression
• (2004) BMC Medicine 2 2
• Cotrell (Queens) Prokiceticin 2 modulates the
  excitability of subfornical organ neurons
  (2004) J Neurosci. 242375
• Thompson (Toronto) Variant of the Orexin2/hcrt2
  receptor gene identified in patients with
  excessive daytime sleepiness and patients with
  Tourettes syndrom comorbidity (2004) AM. J.
  Med. Genet. 129 B(1)69-75
• Nicholls (UBC) Assessing risk of violence among
  male and female civil psychiatric patients
  The HCR-20, PCLSV, and VSC (2004) Behav. Sci
  Law 22 127-158
• Kogan (McGill) Differential impact of the FMR1
  gene on visual processing in fragile X
  syndrome
• (2004) Brain 127 591-601

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Brain Star of the year

• 2003 Michelle Aarts and Yitao Liu
• Aarts M., Liu Y., Bessoh S., Arundine M., Gurd
  J., Wang Y.T., Salter M. (2002) Brain damage by
  perturbing NMDA receptor PSD-95 protein
  interactions Science 298846-850.
• 2004 Jeffrey Coull
• Coull J., Boudreau D., Bachand K. Prescott S.A.,
  Nault F., De Koninck P.Y. (2003) Transynaptic
  shift in anion gradient in spinal lamina I
  neurons as a mechanism of neuropathic pain.
  Nature 424938-942

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Strategic Training Initiativein Health Research

• First competition 2001
• CIHR central and Institutes supported
• 51 teams funded
• 8 of them related to INMHA
• 300K per year for 6 years
• Cross-pillars and multi-centres favoured

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Strategic Training Initiativein Health Research

• First Competition 2001-2002
• Teams related to INMHA
• Cameron (Waterloo) Tobacco Research
• De Koninck (Laval) Neurophysics Setting new
  frontiers in neurosciences with material
  sciences and photonics
• Fenster (UWO) Vascular and cerebrovascular
  transdisciplinary training program
• Houry (Toronto) Protein folding. Principles and
  diseases
• McGrath (Dalhousie) Pain in child health
• Reithmeier (Toronto) Structural biology of
  membrane proteins linked to disease
• Salter (Toronto) Pain research. From molecules to
  community
• Vincent (UBC) Neurobiology and behaviour

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Strategic Training Initiativein Health Research

• Second competition 2002
• Funded by each Institute
• INMHA received 15 LOI
• With internal and external (FRSQ, NAAR) partners
  INMHA is associated to 10 successful applications
• Funding for six years started in April 2003

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Strategic Training Initiative in Health Research
Second Competition 2001-2002

• Antel (McGill) Integrated Training Program in
  basic and clinical aspects of
  neuroinflammation
• Chaudhuri (McGill) McGill integrative
  neurobehavioral training program focus on
  regenerative medicine and early life events
• Fombonne (McGill) Training program in autism
  research
• Goldner (UBC) Building capacity in mental health
  and addiction services and policy research
• Holden (Queens) Transdisciplinary
  inter-institute training program in autism
  spectrum disorders
• Kirmayer (McGill) Culture and mental health
  services
• Meaney (McGill) Genes, environment and health
  training program
• Mishara (UQAM) Formation interdisciplinaire en
  recherche sur le suicide et sa prévention
• Selby (Toronto) Tobacco use in special
  populations
• Wilson (York) CIHR strategic training program in
  vision research

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STIHR WORKSHOP Nov. 28-29, 2005

• A STIHR Workshop will be held on Nov. 28-29, 2005
  in Montreal, for all training program grants
  related to INMHA

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INMHA Salary Awards - Spring and Fall 2002

• Doctoral Research Award (11)
• Post-doctoral Fellowship (8)
• Senior Research Fellowship (1)
• New Investigators (2)
• Clinician Scientists (2)
• Senior Investigator (1)

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INMHA Doctoral Research Award

• Alain (Montréal) Les processus C-REM induits par
  stimulations vibratoires pendant le sommeil
  NREM
• Arudine (Toronto) Cellular and molecular
  mechanisms of secondary neurotrauma
• Beauchamps Étude des résultats des traitements
  psycho-
• (McGill) sociaux auprès des jeunes présentant
  un premier épisode de schizophrénie
• Bédard (Toronto) Application of virtual reality
  technology in assessing cognitive function in
  children with ADHD
• Brouillette (McGill) Action neuroprotectrice de
  lIGF-1 Rôles des akt kinases et régulation
  génomique
• Caraiscos (Toronto) Enhancement glycine receptor
  function by insulin receptor-mediated pathways

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INMHA Doctoral Research Award

• Ghasemlou Characterization of trkA and p75
  neurotrophin (Queens)
  receptor function in sympatetic and sensory
  axonal growth
• Lefebvre (Dalhousie) Use of event-related brain
  potentials and standardized
  neuropsychological stimuli in the
  understanding and assessment of working
  memory abilities in patient following brain
  injury
• Ohayon (Toronto) Recurrent neural network models
  of kindling
• Sharif (McGill) Differential contribution of the
  nervous system to inflammation and joint
  destruction in an animal model of
  monoarthritis
• Thibeault (Laval) Rôle de la réponse immune dans
  le système nerveux central

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INMHA Fellowships

• Henriques Kinesthetic guidance of limb
  movements (Minneapolis) Kinesthetic spatial
  perception and its role in action
• Moller (Toronto) Screening for neurocognitive
  impairment and road safety in sleep disorders
  using the virtualized environment of a
  computerized driving simulator
• Powell (Dalhousie) Effects of fetal neurons and
  stem cell derived neurons on pre- and
  post-synaptic gene expression in striatum
  and substantia nigra
• Rose (Valencia) Effect of acute brain liver
  failure on cerebral function Brain
  metabolism and signal transduction pathways
• Van der Werf Cortical oscillations in the
  healthy and disordered (McGill) brain Studies
  with transcranial stimulation

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INMHA Senior Research Fellowships

• Marotta (York) Hemispatial neglect A
  multidisciplinary investigation of the
  effect on visual perception and visually
  guided action

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INMHA New Investigators

• Joober (McGill) Genetics of schizophrenia From
  animal models to human studies
• Yan (Calgary) Neural mechanisms of
  learning-induced auditory plasticity Role of
  cortical acetylcholine and corticofugal
  modulation

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INMHA Clinician scientists

• Daskalakis A study of cortical inhibition and
  (Toronto) plasticity in schizophrenia using
  transcranial magnetic stimulation
• Dupré (McGill) Clinical and genetic study of a
  new form of recessive cerebellar ataxia
  frequently encountered in the Beauce
  region (Québec) and the surrounding area

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INMHA Senior Investigator

• Szatmari (McMaster) Understanding developmental
  trajectories in autism

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INMHA Strategic Priority One

• Grant Funding and
• Strategic Initiatives

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INMHA First Two Initiatives

• IHRT
• Karpati et al. (McGill University)
• Gene Therapy for Neurological Disorders
• (ICR, IHDCYH, IMHA, Neuroscience Canada, Muscular
  Dystrophy of Canada)
• CAHR (IAPH/INMHA Special Project)
• Kirmayer et al. (McGill University)
• National Network for Aboriginal Mental Health
  Research

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Research in emerging areas

• Institute-specific initiatives
• New Emerging Team (NET)
• 3 to 6 independent investigators
• senior and junior investigators
• Collaborative multidisciplinary research
• Up to 300,000 per year for five years

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Research in emerging areas

• NET Research Themes for 2001-2002
• Discrimination and stigma
• Understanding the placebo effect
• Neurodevelopment and early life events
• Computational neurosciences and artificial
  intelligence

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Neurodevelopment and early life events

• Brien (Queens) Fetal alcohol syndrome,
  oxidative stress and innovative therapies
• Honer (UBC) Interactions of development, early
  life experience, and genetic predisposition
  in schizophrenia
• Paus (McGill) Long-term consequences prenatal
  exposure to maternal cigarette smoking on
  brain structure, function and mental health
  in adolescence Role of genes and
  environment in brain development
• Robaey (Montréal) Inattention, impulsiveness and
  restlessness in childhood Heritability,
  genetics, neuropsychology and
  psychophysiology (KIDNET)

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Computational neurosciences and artificial
intelligence

• Kalaska Learning task decomposition in
• (U de Montréal) large-scale biological and
  artificial neural networks
• McIntosh Development of integrative
• (U of Toronto) computational neuroscience
  program to understand human mental
  function

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Research in emerging areas

• NET Research Themes for 2002-2003
• Discrimination and stigma (Re-issued)
• Understanding the placebo effect (Re-issued)
• Post-traumatic stress syndrome
• Comorbidity and co-occurrence
• Regenerative Medicine - Neurosciences

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Post traumatic stress disorder

• Asmundon Understanding Risks Factors,
• (U of Regina) Co-morbidity, and Global
  Health Issues in PTSD
• Coupland  STRESS  Stress, Trauma
• (U of Alberta) and Recovery Early Stage
  Studies

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Understanding the Placebo Effect

• Lavigne Comprendre leffet placebo à
• (U de Montréal) partir détudes expérimentales
  et cliniques sur le sommeil et la douleur
  impliquant des états de vigilance altérés

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Regenerative Medicine _ Neuroscience

• Weaver
• (UWO)
• In partnership with
• Ontario Neurotrauma Foundation

• Spinal Cord Injury Discovery and development of
  rescue and repair strategies.

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Research in emerging areas

• NET Research Themes for 2003-2004
• Neuroethics
• Downie (Dalhousie University)
• Neuroimaging ethics From theory to practice
• Suicide Prevention targeted to Aboriginal People
  (with IAPH)
• Andersson (CIET, Ottawa) Aboriginal Community
  Youth Resilience Network (ACYRN) Community-led
  research and resources to prevent youth suicide
• Turecki (McGill U.) Understanding and acting on
  Aboriginal suicide A new multidisciplinary
  research team

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Research in emerging areas

• NET Research Themes for Dec. 2004
• Neuroethics (re-issued)
• Suicide prevention targeted to Aboriginal People
  (re-issued)
• Mental Health in the Work Place (with IPPH)
• For June 2005
• Mental Health in the Work Place

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Research in emerging areas

• Analysis of the Canadian Health Survey on Mental
  Health and Well-Being (Health Services and
  Policy Research, Gender and Health as well as
  Statistics Canada, Ontario Problem Gambling
  Research Centre and Northern Health Research
  Initiative)
• Caron (McGill U) Le soutien social, la santé
  mentale et le bien-être des populations pauvres
  au Canada
• Cole (McGill U) Health services use by Canadian
  seniors with major depression
• Cox (U of Manitoba) Two population-based mental
  health studies using the CCHS (cycle 1.2) social
  phobia and problem gambling
• DArcy (U of Saskatchewan) A mental health
  divide? Rural-urban and intra-rural differences
  in mental health services

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Research in emerging areas

• Analysis of the Canadian Health Survey on Mental
  Health and Well-Being (2)
• Dewa (U of Toronto) Psychiatric disorders,
  chronic physical conditions, workplace stress and
  disability in the Canadian working population
• Fournier (U de Montréal) Troubles anxieux chez
  les jeunes de 15 à 24
• ans évolution, déterminants et recours aux
  services
• Lesage (U de Montréal) Utilization of services
  for mental health reasons-
• cross provincial differences in rates and
  determinants
• Newman and Thompson (U of Alberta) Prevalence and
  correlates of pathological gambling
• Patten et al. (U of Calgary) Descriptive
  epidemiology of major depression in the Canadian
  population
• Roman (U of Toronto) Gender issues in depression
  and anxiety for Canadians less than 65 years of
  age

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Research in emerging areas

• Analysis of the Canadian Health Survey on Mental
  Health and Well-Being (3)
• Rush (U of Toronto) Concurrent substance use and
  mental disorders in Canada prevalence and impact
  on service utilization
• Sareen (U of Manitoba) Correlates of mental
  health services utilization and emotional
  well-being Analysis of the CCHS survey cycle 1.2
• Stewart et al. (U of Toronto) The relation
  between work-related factors and mental health in
  Canada men and women
• Streiner and Cairney (U of Toronto) Psychiatric
  disorders, associated risk factors and mental
  health services use among adults aged 55 and
  older in Canada
• Tempier (McGill U) General practice and mental
  health care a Canadian-Australian comparative
  study

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Research in emerging areas

• Analysis of the Canadian Health Survey on Mental
  Health and Well-Being (4)
• Waraich and Streiner (UBC) Validation of
  administrative cases of major depressive disorder
  using CCHS 1.2 data
• Zumbo (UBC) Bias in self-reported health services
  utilization in the CCHS on mental health and
  well-being Influences of age, gender, personal
  characteristics and patterns of care

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Research in emerging areas

• In partnership with IHSPR
• Vingilis (UWO) Marrying knowledge generation with
  knowledge diffusion and utilization  The
  consortium for applied research and evaluation in
  mental health
• In partnership with IHSPR
• Kisely (Dalhousie U) Measuring quality in mental
  health services across Nova Scotia evaluation of
  a demonstration site
• Dewa (U Toronto-CAMH) Examining the effectiveness
  of a collaborative care model for individuals
  with severe mental illness
• In partnership with IGH
• Violence, Gender and Health across the lifespan
• Pepler (York U) Preventing violence in the lives
  of girls and women A focus on relationships
• McMillan (McMaster U) Health impacts of violence
  across the lifespan. A multidisciplinary approach.

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Research in emerging areas

• In partnership with the Fogarty Centre of the NIH
• Stigma and Global Health
• C. Benoit (University of Victoria)
• Joint RFA to be re-issued in 2006

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INMHA Bridging Funds

• One-year operating grants for highly-rated
  proposals
• Priority Announcements
• March 2002 Competition (13 projects funded)
• September 2002 Competition (3 projects funded)
• March 2003 Competition (1 project funded)
• September 2003 (3 projects funded)
• March 2004 (3 projects funded)
• September 2004 (5 projects funded)
• March 2005 (6 projects funded)
• Majority successful in obtaining CIHR/NIH
  operating grants in subsequent competition (70)

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INMHA Bridging Funds March 2002

• Bartha (UWO) Monitoring metabolism and tissue
  magnetic susceptibility during acute focal
  cerebral ischemia
• Brown (UWO) In vivo and in vitro studies of
  EphA3 and EphA4 signaling
• Carlen (Toronto) Synaptic mitochondria
  Physiology and pathophysiology
• Cuello (McGill) Studies on the plasticity of CNS
  cholinergic neurons
• Fehlings (Toronto) Apoptosis after spinal cord
  injury The role of Fas, p75NTR, and NF-kappaB
• Franklin (McGill) Sex steroids and depression as
  modulators of pain sensitivity (with IMHA)
• Gianoulakis (McGill) Alcoholism, central opioid
  activity and stress responses as a function
  of family history and gender

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INMHA Bridging Funds March 2002

• Mishra (McMaster U) Role of catecholamine
  regulated proteins (CRPs) in schizophrenia
• OCraven Understanding the neural mechanisms of
  visual
• (U of Toronto) cognition fMRI studies of human
  extrastriate cortex
• Peters (UWO) Procedures for image-guided
  neurosurgery in the deep brain
• Prat (U de Montréal) Functional analysis of the
  metalloendopeptidase NRDc
• Rossi (UBC) A model for regulated delivery of
  neuropeptides to the CNS through microglia
  mediated gene therapy
• Sullivan (Montréal) Cerebral laterality,
  prefrontal cortex and stress

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INMHA Bridging Funds September 2002

• Gratton, Meaney (McGill) Early experience and the
  development of the corticolimbic dopamine
  system
• Niles (McMaster) Neurotrophine induction and
  neuroprotection by melatotin in
  Parkinsons disease
• Vaucher (Montreal) Modulation cholinergique du
  cortex visuel du rat

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INMHA Bridging Fund March 2003

• Antel (McGill) Cellular immune injury of human
  oligodendrocytes

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INMHA Bridging Fund September 2003

• Kerouac (Memorial U.) Regulation of orexin
  (hypocretin) neurons by monoaminergic and
  cholinergic systems
• Létourneau Support for women who experienced
  symptoms
• (U of Alberta) of postpartum depression
• Zhang (U of Toronto) Cellular mechanisms of
  hippocampal sharp wave and associated fast
  oscillations

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INMHA Bridging Funds March 2004

• Sarret (U de Sherbrooke) Régulation des
  récepteurs de la neurotensine Implication
  dans le contrôle de la douleur
• Karim (McGill U) Towards an understanding of
  reconsolidation
• Joanisse (UWO) The brain bases of speech
  perception Imaging studies of normal adults
  and developmentally impaired children

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INMHA Bridging Funds September 2004

• Fouad (U of Alberta) Combining axonal growth
  promoting treatments with rehabilitative
  training
• Magoski (Queenss U) The role of calcium channel
  in controlling neuronal excitability
• Morshead (U of Toronto) Examining the function
  and regulation of adult mammalian neural stem
  cells
• Soja (UBC) State-dependent control of spinal
  interneurons
• Zadra (U of Montreal) Precipitating factors and
  psycho- physiological correlates of adult
  somnambulism

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Bridging Funds March 2005

• Allen (U. of Alberta) In-vivo magnetic resonance
  spectroscopic quantification of brain
  metabolites
• Chahine (U. of Laval) Modulation of nav1.7 and
  nav1.8 two peripheral nerve Na channels by
  local anesthetics and auxiliary
  beta-subunits
• Mishra (McMaster U) Role of synapsin II in
  schizophrenia and its regulation by typical
  and atypical antipsychotic drugs
• Poulter (U. Carleton) GABA-A receptor plasticity
  in response to experimental epilepsy
• Ross (U. of Alberta) In vivo exploration of brain
  connectivity in temporal lobe epilepsy
• Duquette (U. of Montreal) Further exploration of
  the mechanisms underlying motor dysfunction
  in antipsychotic drug-treated monkeys

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INMHA Four Major Strategic Initiatives

• Nicotine Addiction and Tobacco Abuse
• Co-occurrence of brain disorders with other
  health problems and comorbidity
• Early Life Events and First Episodes of Brain
  Disorders
• Regenerative Medicine and Nanomedicine

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1st Major Strategic Initiative

• Nicotine addiction and tobacco abuse
• National Summit, Ottawa, April 2002
• Report on CTCRI Web site (www.ctcri.ca)
• RFA Advancing the science to reduce tobacco
  abuse and nicotine addiction June 2003
• Partners
• CIHR INMHA, ICR, IAPH, ICRH, IGH, IHDCYH
• National Cancer Institute, Canadian Cancer
  Society, Heart and Stroke Foundation, Health
  Canada, Canadian Lung Association, Association
  pulmonaire du Québec
• Funding in 2004

73
1st Major Strategic Initiative

• Nicotine addiction and tobacco abuse
• Two teams supported for 5 years by INMHA and many
  other partners (June 2004)
• P. Clarke (McGill U.)
• Nicotine addiction Behavioral and brain
  mechanisms from rodents to humans
• P.W. McDonald (U. of Waterloo)
• A Pan-canadian Resource Network for Tobacco
  Control Research, Policy and Practice

74
1st Major Strategic Initiative

• Nicotine addiction and tobacco abuse
• Re-issued in December 2004
• RFA on Research in Addiction with CTCRI, CCSA,
  OPGRC and other partners
• http//www.cihr-irsc.gc.ca/e/25700.html
• Tobacco Abuse and Nicotine Addiction (re-issued)
  and Community based research grants with CTCRI
• www.ctcri.ca
• Funding starts in 2006

75
2nd Major Strategic Initiative

• Co-occurrence of brain disorders with other
  health problems
• NET Program May 2002
• Consultation Workshop on September 22-23, 2005,
  in Ottawa to plan development of a RFA with
  partners in June 2006

76
3rd Major Strategic Initiative

• Early Life Events and
• First episodes in Brain Disorders
• In partnership with IHDCYH
• Steering Committee, Halifax, October 2002
• Workshop, Montréal, February 9-10, 2004
• Report on the Web, Spring 2004
• RFA in mid-December 2004
• www.cihr-irsc.gc.ca/e/25650.html
• Funding for team grants to be announced in 2006

77
4th Major Strategic Initiative

• Regenerative Medicine and Nanomedicine
• (1 of 4 CIHR Large Strategic Initiatives)
• stem cells, nanomedicine, gene therapy, tissue
  engineering, rehabilitation
• Brain and spinal cord repair
• IHRT on Gene therapy (Karpati, McGill U.)
• NET on Spinal Cord Injury (Weaver, UWO)
• Vision and hearing losses
• Partners
• CIHR INMHA, IG, ICR, ICRH, III, IMHA
• Canadian Genetic Diseases Network, Canadian
  Stroke Network, Juvenile Diabetes Research
  Foundation International, Heart and Stroke
  Foundation, NSERC, NRC, Neuroscience Canada,
  Stem Cell Network, Canada Space Agency, etc
• Nanomedicine Workshop, Feb. 2003
• Annual Meeting - Nanomedicine, Feb. 2004 and
  March 2005
• RFA in June 2003, re-issued in June 2004 and June
  2005
• For details www.regenerativemedicine.ca

78
4th Major Strategic Initiative

• Regenerative Medicine and Nanomedicine
• 1st competition
• New Discoveries High Risk Grant (with IG)
• Jefferies (UBC) Delivery of therapeutics proteins
  across the blood-brain barrier
• Invention, Tools and Devices
• Kirby (Dalhousie) Rear anti-tip devices for
  manual wheelchairs Effect of new vs
  conventional design on performance, user
  satisfaction and social participation
• Scott (Queens) KINARM - A robotic tool for
  objective assessment of upper limb motor
  function
• De Koninck Novel microprobes for combined
  optical and
• (U. Laval) electrical recording in vivo

79
4th Major Strategic Initiative

• Regenerative Medicine and Nanomedicine
• 5 year Team Grants 1st competitition
• W. Chan (U of Toronto) Quantum dot-based
  biomolecular imaging
• M. Fehlings (U of Toronto) Regenerative medicine
  strategies for spinal cord injury repair
  Integration of stem cell biology, nanotechnology,
  bioengineering approaches and neurosurgical
  application
• A. Daar (U of Toronto) Regenerative Medicine
  Ethical, Environmental, Economic,  Legal and
  Social Issues Network
• S. Rivest (Université Laval) Engineered bone
  marrow stem cells (BMSCs) for treatment of CNS
  injuries and diseases
• I. Brunette (U de Montréal) Femtosecond Laser
  Assisted Corneal Posterior Lamellar
  Transplantation with Endothelial Enhancement
  Technological Developement and Socioeconomic
  Impact
• W. Stanford (U of Toronto) Stem cell fate
  analysis and manipulation
• J. Galipeau (McGill U) Cardiovascular and
  respiratory stem cell plasticity CARE project.
  
• Y. de Koninck (Université Laval) Nanotools for
  neuropharmacology

80
4th Major Strategic Initiative

• Regenerative Medicine and Nanomedicine
  Innovative Approaches in Health Research
• RFA re-issued in June 2004 and June 2005
• Team Grants
• New Discoveries High Risks Seed Grants
• Funding starts in 2006 and 2007
• www.cihr-irsc.gc.ca/e/22842.html

81
INMHA Strategic Priorities Two and Four

• Partnership and
• International Visibility

82
Inter-Institute Partnerships

• Include most if not all CIHR Institutes, for
  example
• Analysis of the Canadian Community Health Survey
  on Mental Health and Well-Being (IHSPR, IGH and
  Statistics Canada, Ontario Problem Gambling
  Research Centre and Northern Health Research
  Initiative)
• Gene Therapy (ICR, IHDCYH, IMHA and NeuroScience
  Canada and Muscular Dystrophy Association of
  Canada)
• Training Program in Aboriginal Mental Health
  (IAPH)
• Alcoholism and Gender (Gender and Health)
• ICE (IHSPR)
• Outreach Initiative for NGOs (IGH)
• Strategic Training Initiative in Health Research
  (most institutes)
• One-year Bridging Funds
• Large Strategic Initiatives

83
National Partnerships

• EJLB-CIHR Michael Smith Chair in Neurosciences
  and Mental Health with the Royal Society of
  Canada and EJLB Foundation
• (Min Zhuo, University of Toronto)
• Barbara Turnbull Award with Barbara Turnbull
  Foundation for Spinal Cord Research and
  NeuroScience Canada
• (50,000 added to the top grant in spinal cord
  research)
• David Kaplan, U of Toronto, 2002
• Mohammad Sawan, École polytechnique, Montréal,
  2003
• David Bennett, U of Alberta, 2004
• Canadian Tobacco Control Research Initiative /NCI
• RFA Advancing the Science to Reduce Tobacco
  Abuse and Nicotine Addiction

84
National Partnerships

• Ontario Neurotrauma Foundation
• NET Program on Regenerative Medicine /
  Neurosciences (Weaver, UWO)
• Regenerative Medicine and Nanomedicine
• Fonds de la recherche en santé du Québec
• Joint Funding for 6 Strategic Training Initiative
  Grants
• McGill University and UQAM
• Canadian Medical Association
• Physician Mental Health and Well-Being Grants
• Brewster (U of Toronto) Development of a guide
  for common indicators fo Canadian Physician
  Health Programs
• Maranda (U Laval) The psychodynamics of the work
  of physicians A well-being and mental health
  issues

85
National Partnerships

• Neurobiology of Psychiatric Disorders and
  Addictions Grants Programs (to be repeated in
  2005)
• Canadian Psychiatric Research Foundation and
  Astra Zeneca (with CIHR/RxD)
• Boksa (McGill University)
• Maternal infection during pregnancy as a risk
  factor for schizophrenia
• Li (University of Saskatchewan)
• A neuroprotective mechanism of atypical
  antipsychotics in haloperidol-induced
  neurotoxicity
• Phillips (University of British Columbia)
• Biochemical and behavioural characterization of
  an animal model of schizophrenia induced by
  sensitization to amphetamine
• Van Tol (University of Toronto)
• Identification of psychosis susceptibility genes
  using C. elegans

86
National Partnerships

• Astra Zeneca Canada / Royal University Hospital
  Foundation --U. of Saskatchewan / Schizophrenia
  Society of Saskatchewan
• Chair on Schizophrenia
• Ontario Problem Gambling Research Centre
• Eric Single Studentship
• Analysis of Canadian Community Health Survey on
  Mental Health and Well-Being
• Workshop on Problem Gambling
• RFA on Research in Addiction
• Canadian Centre for Substance Abuse (CCSA)
• Alcohol and Illicit Drugs Forum
• Joint RFA on Research in Addictions
• Eric Single Studentship
• NSERC, NRC, CSA
• Regenerative Medicine and Nanomedicine

87
National Partnerships

• Health Canada
• Nicotine Addiction and Tobacco Abuse
• Regenerative Medicine and Nanomedicine
• Workshops
• Suicide Research in Canada
• Alcohol and Illicits Drugs
• Statistics Canada
• Analysis of the Canadian Community Health Survey
  on Mental Health and Well-Being

88
National Partnerships

• Schizophrenia Society of Canada
• Co-sponsor of New Investigator Award
• NeuroScience Canada
• Barbara Turnbull Award for Spinal Cord Research
• National Brain Repair Program
• F. Miller (U of Toronto) Novel Appproach to CNS
  white matter repais
• M. Salter (U of Toronto) Transforming research
  on chronic pain in Canada
• Y.T. Wang (UBC) Novel therapeutic strategies to
  repair brain abnormalities in psychiatric
  disorders

89
National Partnerships

• Vascular Health and Dementia Research Grant
  Program (to be repeated in 2005)
• IA, CIHR-RxD, Heart and Stroke Foundation of
  Canada, Alzheimer Society of Canada and Pfizer
  Canada
• G. Boulay (Université de Sherbrooke)
• Intracellular calcium signaling and vascular
  dementia
• P. Carlen (University of Toronto)
• Alzheimer's Disease, Aging and the Ischemic
  Synapse
• D. Corbett (Memorial University of Newfoundland)
• Exercise, aging and cognitive impairment
• W. Zhang (National Research Council of Canada)
• Neurovascular Unit in Alzheimer's Disease and
  Cerebral Amyloid Angiopathy

90
National Partnerships

• Heart and Stroke Foundation of Canada
• RFA on Nicotine Addiction and Tobacco Abuse
• RFA on Regenerative Medicine and Nanomedicine
• Stem Cell and Stroke Networks of Excellence
• Miller (U of Toronto)
• Weiss (U of Calgary)

91
International Partnerships

• Japan-Canada Post-doctoral Fellow Exchange
  Program
• 3 Japanese post-docs
• Program terminated and replaced by
• JSPS-CIHR Joint Health Research Program
• New joint funding program with Japan Society for
  the Promotion of Science
• INMHA lead CIHR Institute
• First joint competition September 2003
• One joint grant funded
• Michael Salter, U. of Toronto
• Re-issued in September 2004
• 6 grants funded

92
International Collaborations

• NIH Institutes and NIH Fogarty International
  Center
• (see NIH Web Site at www.fic.nih.gov) to be
  repeated in 2005
• Stigma and Global Health
• joint RFA in 2002
• C. Benoit (University of Victoria)
• Joint RFA to be re-issued in 2005
• Tobacco
• Brain Disorders in the Developing World
• joint RFA in 2002 to be repeated in 2005
• Workshop on Manual Therapies in Bethesda,
  Maryland, on June 9-10, 2005 with IMHA
• RFA, Identifiying Autism Susceptibility Genes,
  and Fragile X Susceptibility Genes

93
International Collaborations

• NIH Institutes and NIH Fogarty International
  Center
• RFA on Identifying Autism Susceptibility Genes
  with many partners including
• NIH NIMH, NINDS, NICHDS, NIEHS, NIDCD
• CIHR INMHA, IHDCYH and IG
• National Alliance for Autism Research
• Health Research Board of Ireland
• Southwest Autism Research and Resource Center
• Cure Autism Now
• Similar on Fragile X
• Discussion Nanomedicine

94
International Collaborations

• INMHA-IBRO Neurosciences Schools
• Partnership with International Brain Research
  Organization to particularly support neuroscience
  schools in developing countries
• African Advanced Neuroscience School
• September 2003
• Two Schools in 2004
• Morocco and Argentina
• Two Schools in 2005
• Kenya and Argentina
• For more details www.ibro.org

95
International Collaborations

• National Alliance for Autism Research (U.S.)
• Co-sponsor of two CIHR Strategic Training
  Programs in Autism Research
• Eric Fombonne, McGill University
• Jeannette Holden, Queens University
• Partner in a RFA on Identifying Autism
  Susceptibility Genes with NIH, CIHR and many
  partners

96
International Collaborations

• Canada-Finland-China Collaborative Program in
  Neuroscience
• Joint Program with the Academy of Finland
• MOU signed in Finland, Mar. 2005
• Many grant applications received

97
International Collaborations

• National Alliance for Schizophrenia and
  Depression (NARSAD) (U.S.)
• Joint Young Investigator Awards 2004
• Viau (UBC)
• Misener (University of Toronto)
• Dozois (UWO)
• Savard (Laval)
• Debruille (McGill)
• Repeated in 2005
• Meeting with NARSAD, Schizophrenia Society of
  Canada and Canadian Psychiatric Research
  Foundation (Toronto, Sept. 2005)

98
International Collaborations

• WHO / PAHO
• Mental Health and Addictions in the Developing
  World
• WHO Centre in Gender and Mental Health (with IGH)

99
International Collaborations

• Mexico
• Memorandum of Understanding Signature in Ottawa
  on October 25, 2002
• Institute of Neurology and Institute of
  Psychiatry
• China
• Discussions under way with National Science
  Foundation

100
INMHA Strategic Priority Three

• Knowledge Translation

101
Knowledge Translation

• Cunningham Modeling parent preferences for
  translating
• (McMaster U) scientific knowledge regarding
  children with inter- nalizing and externalizing
  mental health problems
• Forchuk (UWO) Integrating an evidence-based
  intervention in clinical practice
• Manske Understanding and testing KT strategies
  in
• (U of Waterloo) tobacco control evaluation at
  national, provincial and local levels
• McVey Evaluation of a Web-based program
  designed to
• (U of Toronto) evaluate the dissemination of
  best practice
• models in the primary prevention of disorder
  eating
• Varnhagen Strategies for critically appraising
  childrens health
• (U of Alberta) web resources

102
Knowledge Translation

• In partnership with IHSPR
• Kisely (Dalhousie U) Measuring quality in mental
  health services across Nova Scotia evaluation of
  a demonstration site
• Dewa (U Toronto-CAMH) Examining the
  effectiveness of a collaborative care model for
  individuals with severe mental illness

103
Other KT Initiatives

• Neuroscience Schools in developing countries
  sponsored in collaboration with IBRO (2 Schools
  per year)
• September 1-7, 2004 Cape Town, South Africa
• September 13-30, 2004 Cordoba, Argentina
• Topics in Cellular and Molecular Neuroscience
• March 19-27, 2005      Rabat, Morocco
• "Hormones and Brain
• Nov. 19  - Dec. 6, 2005    Buenos Aires,
  Argentina
• Receptors, Channels, and Synapses

104
Other KT Initiatives

• Outreach Initiative 2004
• Program aimed to help NGO with communication and
  dissemination of information to target audience
• First edition in collaboration with IGH
• Autism Society of Canada
• Partners seeking solutions with seniors and
  Creative Retirement Manitoba
• Canadian Alliance on Mental Illness and Mental
  Health
• Canadian Mental Health Association, Ontario

105
Other KT Initiative

• Outreach Initiative 2005
• Autism Society of Ontario
• Canadian Coalition for Seniors Mental Health
• Center of Neurosciences Studies (Queens
  University)
• Brain Awareness Week
• INMHA sponsors BAW in Montreal,
  Saskatoon,Toronto, British Columbia, and Halifax

106
Other KT Initiatives

• Web site The Brain from top to bottom
• Link available on INMHA web page
• www.cihr-irsc.gc.ca/e/8602.html
• Web site designed to popularize scientific
  information about the brain and human behaviors
  and aimed at all public
• Organized by topics and levels of explanation
• Approximately 700 visitors/day

107
INMHA Strategic Priority Five

• Effective Organizational and Operational Structure

108
INMHA Organizational andOperational Structure

• Frequent IAB meeting with summaries on the Web
• IAB organized in Focus Groups
• Annual Meeting with all stakeholders
• Quaterly Newsletter
• Two staff dedicated to National and International
  Partnerships
• Direct involvement in many CIHR committees and
  working groups

109
Recent and Upcoming Events

• Comorbidity and co-occurrence consultation
  workshop Sept 22-23, 2005
• First Performance Evaluation Report (Fall 2005)
• Fourth Annual Meeting, Vancouver, October 2005
• INMHA-STIHR Workshop in Montreal, Nov. 2005, with
  NAAR and FRSQ
• Second Strategic Plan to be developed in
  2005-2006 in collaboration with partners

110
How to get in touch with us?

• Astrid Eberhart, Assistant Director, Partnerships
  / International
• aeberhart_at_cihr-irsc.gc.ca
• Barbara Beckett, Assistant Director
• bbeckett_at_cihr-irsc.gc.ca
• Asimina Xidous, Project Officer
• axidous_at_cihr-irsc.gc.ca
• Eric Marcotte, Lead Lead
• Regenerative Medicine
• eric.marcotte_at_regenerativemedicine.ca

• Montreal Office
• Rémi Quirion, Scientific Director
• remi.quirion_at_douglas.mcgill.ca
• Richard Brière, Assistant Director
• richard.briere_at_douglas.mcgill.ca
• Ramia Jabr, Executive Manager
• ramia.jabr_at_douglas.mcgill.ca
• Rocio Benalcazar,
• Administratrive Assistant
• rocio.benalcazar_at_douglas.mcgill.ca

111
Visit us at...
www.cihr-irsc.gc.ca and read the Brain Brief,
INMHA newsletter www.thebrain.mcgill.ca and read
about the brain from top to bottom