Microsomal PowerPoint PPT Presentations

Microsomal Heme Oxygenase System

Title: No Slide Title Author: Pfizer Inc Last modified by: snydem03 Created Date: 1/19/2001 3:22:54 PM Document presentation format: Custom Company

... anti-microsomal antibodies Multiple sclerosis anti ... pH of body fluids gastric acid acid pH of 2 in ... Mono clonal also applies to a class ...

Absorption, Distribution & Biotransformation. II. Biotransformation. Microsomal enzymes ... Induction of microsomal detox enzymes. Block receptor site for other toxin ...

Useful drugs may have no benefit because doses are too small to establish therapy ... Microsomal cytochrome P450 monooxygenase family of enzymes, which oxidize drugs ...

http://www.benbest.com/health/alcmetab.gif. microsomal ethanol-oxidizing system (MEOS) ... http://health.yahoo.com/media/mayoclinic/images/image_popup ...

Metabolism. Chemical transformaion of xenobiotics. Occurs in ... Oxidize diamines, histamine. MAO like enzymes in plants. Non-microsomal enzymes (Phase 1) ...

Metabolism. Chemical transformaion of xenobiotics. Occurs in ... Oxidize diamines, histamine. MAO like enzymes in plants. Non-microsomal enzymes (Phase 1) ...

Acido C lico ( m s abundante) y cido desoxic lico.(Primarios) ... La enzima importante es la 7?-hidroxilasa de colesterol una enzima microsomal ...

The role of chemoquines in asthma.Ann Allergy Asthma and Immunol 2006;96(6):819-25 EPOC FISIOPATOLOGIA TABAQUISMO Epoxido hidrolasa Microsomal Hiperexpresi n de CD11b ...

Facultad de Farmacia y Bioan lisis Escuela de Bioan lisis Biotransformaci n Prof. Jos Rafael Luna Mecanismos de Detoxificaci n Mecanismos de detoxificaci n ...

A Thyroid Blood Test to detect thyroid disorder is used to assure that the thyroid hormone is well regulated and under control. This profile includes assessing of thyroid hormones, which helps in determining ailments like dry skin, hair fall, brittle nails, pale skin, fatigue, excessive sleep, reduced concentration, unexplained weight gain or loss and sensitivity to temperature.

A Thyroid Blood Test to detect thyroid disorder is used to assure that the thyroid hormone is well regulated and under control. This profile includes assessing of thyroid hormones, which helps in determining ailments like dry skin, hair fall, brittle nails, pale skin, fatigue, excessive sleep, reduced concentration, unexplained weight gain or loss and sensitivity to temperature.

Chapter 13. Drug Metabolism Introduction: the process of drugs in the body includes absorption, distribution, metabolism and elimination. Drug metabolism is also ...

MLAB 2401: Clinical Chemistry Keri Brophy-Martinez Assessment of the Thyroid Historical Procedures Basal Metabolic Rate Measured rate of oxygen consumption over a 15 ...

Aromatic hydroxylation Aliphatic hydroxylation Epoxidation Dealkylation CYP1A Metabolize polycyclic hydrocarbons Are induced by polycyclic hydrocarbons Found in ...

Drug Metabolism By Dr. fatmah alomary Falomary@ksu.edu.sa

PHARMACOKINETICS DR.ABDUL LATIF MAHESAR KING Dr.SAUD UNIVERSITY October 2008D DRUG ABSORPTION Is the passage of the drug through body barriers or cell membranes to ...

... in the liver and lung were determined at 4 h after the injection. ... Numbers at the top denote amino acid position within the protein.

COPD: Epidemiology, Pathogenesis, & Pathophysiology Wyatt E. Rousseau, MD May 11, 2006 COPD Definition Chronic obstructive pulmonary disease (COPD) is a preventable ...

Biotransformation Prepared by Prof .Abdulkader.H.El Daibani * Biotransformation Biotransformation (metabolism) of drugs: As most drugs are lipid soluble ...

Pulmonary TB Clinical uses Severe , life-threating form of T.B. as meningitis, disseminated disease. Adverse Effects Ototoxicity Nephrotoxicity Neuromuscular block ...

Industry TSE clearance studies for plasma-derived Factor VIII (pdFVIII) Dr. Thomas R. Kreil, Chair, PPTA Pathogen Safety Steering Committee FDA TSE Advisory Committee

Aliphatic hydroxylation. Aliphatic epoxidation. Heteroatom ... Sulfate group added to hydroxyl groups present on phenols or aliphatic alcohols. Enzyme: ...

Pure proteins are required for structural analysis ... supernatant. transfer. supernatant. transfer. supernatant. 10,000 g. 100,000 g. Pellet. mitochondria ...

Located in endoplasmatic reticulum (liver and other cells) ... from pieces of the endoplasmic reticulum present in homogenates of tissues or cells: ...

Title: Antimycobacterial drugs Author: DTK Last modified by: Ahmed Created Date: 5/28/2006 9:22:10 AM Document presentation format: On-screen Show (4:3)

... pathways for the metabolism of 3,3',4,4'-TCB in beluga whale liver microsomes. ... PCB and DDE metabolites in beluga whale (Delphinapterus leucas) from the St. ...

Alcohol and the brain Prof. Hanan Hagar Pharmacology Unit College of Medicine KSU *

MED - For: barbiturate anaesthesia 3-4. benzodiazepines 20 ... sedation, general anaesthesia. enhancement of GABAA receptor function. ketamine ...

(e.g. heparan sulfate, chondroitin sulfate), sulfated ... FAD. FMN. Heme (Fe) NADPH H NADP 2H 2 e- 2 e- 2 e- O2. R-H. O2- R-OH. Cytochrome P450 ...

Drug Biotransformation Elimination of the drugs Drug Biotransformation Metabolism or biotransformation - complex of processes which provide decreasing of toxicity and ...

TREATMENT OF T.B. A special problem within the field of chemotherapy. TREATMENT OF T.B. Treatment is often complex and protracted. Host immune defenses are often ...

drug clearance mechanisms (renal and hepatic) are limited in newborns ... reduced hepatic blood flow. reduced activities of cytochrome P450 enzymes. gender ...

We removed the liver from a normal rat and from a Phenobarbital treated rat. ... Measured Cytochrome P450 2B1 from normal and phenobarbital treated rats. ...

Part 2 Thyroid hormones and antithyroid drugs

Metabolism of Chemicals

Physical Properties. Fate in Environment. Routes of Entry. Transport in ... Physical Properties. Colorless, flammable liquid. Practically insoluble in water ...

Endocrine Physiology Thyroid Bob Bing-You, MD, MEd, MBA Medical Director Maine Center for Endocrinology

Nonprescription Drugs Advisory Committee Meeting, 19 September 2002 ... Potter WZ, Davis DC, Mitchell JR, Jollow DJ, Gillette JR, Brodie BB. IV. ...

Biochemistry

Research. Advanced. Technologies. Drug. Discovery. Scripps Florida. Neurobiology. Immune Disorders ... Research Operating Plan for JNK 2/3 Inhibitor ...

Systemic lupus erythematosus. Immunofluorescent detection of. antinuclear antibody in the ... in lupus nephritis (left) and Anti-renal. basement membrane antibody ...

At least 14 classes: a, b, d, k, l, m, ... Cleavage of the g-glutamyl moiety by g-glutamyl-transpeptidase. Cleavage of the glycine moiety by cysteinyl glycinase ...

... Fe in gut; L-DOPA at blood-brain barrier; anion/cation transport in kidney) ... secretion active carrier process for cations and for anions; inhibited by ...

... Thyrotoxicosis Signs Tachycardia Tremor Warm, moist, flushed skin Goiter Muscle wasting and weakness Symptoms Anxiety, nervousness Palpitations Weight loss ...

Classification of antifungal drugs: Can be classify to six groups. 1- Antibiotics [ Amphotricin B,(AMB), Nystatin, Greiofulvin] 2- Antimetabolities [ 5- Flucytosine,(5-FC), inhibition nucleic acid synthesis] 3- Azoles: a-Imidazoles: Bifonazole, Clotrimazole, Econazole, Ketoconazole, Miconazol. b- Triazoles: Fluconazole, Itraconazole, Voriconazole Inhibition of ergosterol synthesis. 4- Allylamine [Terbinafine, Naftifine ] Inhibition of Lanosterol and Ergosterol synthesis. 5- Echinocandins Inhibit fungal cell wall biosynthesis 6- Miscellaneous Antifungals [Tolnaftant, Undecylenic acid, Benzoic acid, Ciclopirox olamine.]

ANTIEPIL PTICOS Dr. lvaro Caride Difenilhidanto na (fenito na): Ejerce su efecto anticonvulsivante a trav s de la inhibici n de los canales de sodio.

This is my first seminar ppt,i have presented in kmc manipal pharmacology department

Biotransformation of Toxicants Lect 6 Metabolism (Biotransformation) Many xenobiotics undergo chemical transformation (biotransformation; metabolism ...

La disminuci n se debe a: 1. La salida de colesterol de la membrana hacia las ... 3. Utilizaci n del colesterol para la s ntesis de otros esteroides, como las ...

Diagnosis of Thyroid disease includes ... EuthyroidGraves disease with Goiter. Hyperthyroidism Definitions. What is the difference between Thyrotoxicosis ...

... in well-fed animals whose diets contains a high proportions of carbohydrates. ... conditions of restricted caloric intake, on a high-fate diet, or when there ...

This is my first seminar ppt,i have presented in kmc manipal pharmacology department

Movement of a drug from site of. application to the systemic. circulation ... grapefruit juice. DRUG METABOLISM INTERACTIONS. Example : Warfarin Lovastatin ...

Blood Work. What does Thyroglobulin do? Makes T4/T3. When do you test for . Thyroglobulin + Anti-thyroglobulin binding . Ab? Testing for lack of thyroid tissue (e.g ...