Deaminase PowerPoint PPT Presentations

ADA is responsible gene in ~20% SCID. Often fatal, if untreated, due to infections. It was the first form of SCID where: 1. genetic cause was identified (1972),

Adenosine Deaminase Deficient Severe-Combined ... Pegylated ADA (bovine ADA conjugated with polyethylene glycol) at doses of ~15-40 u/kg/wk IM. ...

The cytidine deaminase CEM15 induces hypermutation in newly ... Sequence resulting nucleic acids. Result: No discernible mutations were found upon sequencing ...

Asparate Ribose 5-phosphate PRPP Phosphoribosyl amine IMP ... Nucleotidases Nucleoside phosphorylases Deaminases Xanthine oxidases 3. the final common ...

Deaminate adenosine -Adenosine deaminase. 2. Remove the ribose. -nucleosidase ... oxidize hypoxanthine -deaminate guanine. Make uric acid. -xanthine oxidase ...

uric. acid. Xanthine. Oxidase. free radicals. O. 2. O2. Adenosine. deaminase. inosine. uric. acid. Xanthine. Oxidase. vasodilation. iNOS. cNOS. NO-dependent. LPS ...

Record the letter of your unknown. Innoculate your enterotube. Check ... Phenylalanine deaminase. Urase. Citrate utilization. Innoculation of the Enterotube ...

combine the advantages of both baculovirus and mammalian expression. ... S deaminase genes : bsd from Aspergillus terreus or bsr from Bacillus cereus. ...

AKUT B BREK HASARI Prof Dr Serhan Tu lular M TF Nefroloji Bilim Dal ( 2-microglobulin, 1-microglobulin, adenosine deaminase binding protein, retinol binding ...

Kuyucu N et al. Adenosine deaminase in childhood pulmonary tuberculosis: diagnostic value in serum J. Trop. Ped. 1999; 45(4): 245-7. * Ha sido ...

message is spliced incorrectly (STOP codon becomes. part of coding sequence) ... mRNA can be edited by cytosine deaminase (introduces new stop codon ...

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... were inserted by editing. ... (C U) and Physarum (slime mold) mitochondria (nt insertions) ... Paramyxovirus (G insertions) Editing of Angiosperm Mt RNAs. Most ...

... plus pyrazinamide for 3 months. C) Isoniazid plus rifampin plus pyrazinaminde ... D) Isoniazid plus rifampin plus pyrazinaminde plus ethambutol until culture ...

The accumulation of excess adenosine nucleotides ... allopurinol. Uric acid. alloxanthine - Accumulation of PRPP stimulates de novo purine synthesis ...

Microbiology Unknown Lab. BIO 732. TSI agar. Triple Sugar Iron Agar (a) Red/red (b) control ... (e) Red/yellow with H2S. A B C D E. Penol Red broths. A B C D E ...

26. Deoxyribonucleotide biosynthesis and nucleotide catabolism; drug design and testing ... Enzymes of nucleotide biosynthesis provide targets for cancer ...

Thymidylate synthase oxidizes N5,N10-methylenetetrahydrofolate to ... Fish and most terrestrial mammals oxidize uric acid further before excreting the ...

Hemolytic disease of the newborn is caused primarily by clearance of fetal Rh+ red blood cells that have bound maternal Rh IgG. Cytotoxic clearance of the IgG bound ...

Introns Early vs. Introns Late. Bacterial genomes have no introns ... Other RNAs (including excised introns) must remain in the nucleus ...

Stryer's Biochemistry 5th edition, p. 262-268, 693-712 (or Stryer's Biochemistry 4th ... Required reading: Stryer's Biochemistry 5th Ed., p. 693-694, 709-711 ...

1893 Osler prescribed diets low in fructose as a means to prevent gout ' The ... show that it has strong uric acid transport activity in Xenopus laevis oocytes. ...

Chapter 16 - Enterobacteriaceae MLAB 2434 Clinical Microbiology Cecile Sanders & Keri Brophy-Martinez Chapter 16 - Enterics Family Enterobacteriaceae often ...

In fungi: ergosterol in membranes: higher affinity than. mammalian ... Impair synthesis of ergosterol; inhibit sterol 14 a-demethylase (of cyt. P450) ...

Presentation on "Pathology of tuberculosis of lung". For more information please contact us 9779030507.

The infectious agent is a single-stranded circular RNA molecule ... potato, avocado, chrysanthemum and other plants. PSTV potato spindle tuber viroid ...

Glucose fermentation requires the reoxidation of NADH generated by ... carboxylic acids (lactic, acetic, formic) from pyruvate results in pH indicator ...

Microbiology Unknown Lab BIO 187 TSI agar Triple Sugar Iron Agar (a) Red/red (no sugar fermentation) (b) Control (c) Red/yellow (Glucose fermented but lactose and ...

Carbonic Anhydrase. Rate constants for nonenzymatic (knon) reactions (bottom, blue squares) in units ... (kcat/Km)/knon) is indicated by the length of the ...

Systemic lupus erythematosis. Scleroderma. Immunodeficiency (congenital & acquired) ... Clinical Features of Systemic Lupus Erythematosus ...

classical genetics

What are the 2 phases of. B-cell development? Antigen ... Chronic vs acute. Clinical Diagnosis. 1) Microscopy. 2) gel electrophoresis of. serum proteins ...

Wiskott-Aldrich/XLT WASP. X-SCID Common y-chain XLP SAP/SH2D1A. X-CGD gp91-phox. IPEX FOXP3 ... WASP Mutation scores. Score '0' no WAS/XLT findings, e.g. XLN ...

Chapter 26 Synthesis and Degradation of Nucleotides Synthesis of dTMP from dUMP is catalyzed by thymidylate synthase. This enzyme methylates dUMP at the 5-position to ...

9. AICAR transformylase. 10. IMP synthase. Glu, PPi. Gln. PRPP ... (AICAR) (FAICAR) Trifunctional enzyme. Potent inhibitors of purine nucleotide synthesis ...

Molecular Machinery Molecular basis of cell function Structure vs. Function Molecular mechanisms ENZYME ACTION Na+ K+ pump Cell Signalling ENZYMES Hydrolase ...

Title: PowerPoint Presentation Author: Marc Tischler Last modified by: shahnaz_khaghani Created Date: 12/5/2002 11:36:09 PM Document presentation format

describe and list the way in which immunodeficiencies are ... pyogenic bacteria. MAC complement Meningococcal infections eg. Neisseria. component deficiencies ...

Somsong Nanakorn. ??????????????????????????????????. ??????????????????????/??????? ... 77 primate (non-human) ova are stimulated by pregnant horse serum ...

In some species, such as rat and mouse, a second promoter in the Apobec1 gene ... PCR products from mice at day 2, day 7, day 12, and adult mouse were cloned and ...

... Recife/Brazil; 4 Pos-Graduation in Biological Sciences UFPE, Recife/Brazil; ... located in the city of Recife, Pernambuco state, Brazil, were collected from ...

Classification of antifungal drugs: Can be classify to six groups. 1- Antibiotics [ Amphotricin B,(AMB), Nystatin, Greiofulvin] 2- Antimetabolities [ 5- Flucytosine,(5-FC), inhibition nucleic acid synthesis] 3- Azoles: a-Imidazoles: Bifonazole, Clotrimazole, Econazole, Ketoconazole, Miconazol. b- Triazoles: Fluconazole, Itraconazole, Voriconazole Inhibition of ergosterol synthesis. 4- Allylamine [Terbinafine, Naftifine ] Inhibition of Lanosterol and Ergosterol synthesis. 5- Echinocandins Inhibit fungal cell wall biosynthesis 6- Miscellaneous Antifungals [Tolnaftant, Undecylenic acid, Benzoic acid, Ciclopirox olamine.]

Clinical Uses for Monoclonal Antibodies. In vitro diagnostic agents. In vivo imaging agents ... Link a toxic drug, protein or radioisotope to an MAb with a ...

Rings are labeled I, II, III, and IV. ... Biliary obstruction. It is caused by biliary calculi causes backup and reabsorption of conjugated ...

... PART. 10/16: Pulse Chase, FRAP, Vesicle Transport, SNARES and other proteins involved ... 10/27: Pathogen exit and entry (basic differences and how they ...

Title: Slide 1 Author: Win XP Last modified by: Hanafi Created Date: 8/27/2005 4:06:37 AM Document presentation format: On-screen Show (4:3) Other titles

It is always a good idea to know the first committed step of any pathway. ... Carbon is the wrong position based on isotope labeling exp. Purine ...

Discriminates organisms that can produce proteases to hydrolyze the white milk ... Discriminates organisms that can produce lipases to hydrolyze triglycerides into ...

(part of the phloem vascular tissue: transports sugar, hormones, ... respiration (TCA cycle, etc.) ATP synthesis (and export) other ... Preferential editing ...

... culture was negative for RSV and other respiratory viruses. ... BAL sample was positive for RSV, Moraxella, and S. pneumoniae, treated with antibiotics. ...

Ankara Turkey. MOST COMMON FUNGAL PATHOGENS. Dermatophytes. Candida. Aspergillus. Cryptococcus ... Triazoles: Fluconazole, itraconazole, voriconazole, ...

Transgenic mice (carry trans-gene=extra gene, can either be mutant or wild-type) ... Treatment of the mouse oral cavity with 4-nitroquinoline-1-oxide produced a 66 ...

Distinguished Professor and Investigator, Howard Hughes Medical Institute ... Adenovirus 2 Genome. Locating Genes in Adenovirus. R-loop mapping of late mRNAs ...

Clinical Uses for Monoclonal Antibodies. In vitro diagnostic agents. In vivo imaging agents ... First MAb on market was Orthoclone OKT3, a murine MAb ...