NUCLEAR PHARMACY PRESENTED BY

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NUCLEAR PHARMACYPRESENTED BY

• SARAH MANN
• ROBYN WILSON
• TO THE P2 CLASS ON
• MARCH 24, 2004

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What is Nuclear Pharmacy?

• Specialty area of pharmacy practice
• Dedicated to the compounding and dispensing of
  radiopharmaceuticals
• Diagnostic and therapeutic uses

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Daily Operations

• Milking the Generator
• Preparation of Radioactive kits
• Making individual doses
• Transporting
• Waste Disposal

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99Mo 99mTc Generator

• Source of Radioactivity
• Components of Generator
• Elution or Milking of Generator

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Kit Preparation

• Multi-dose vials
• Ligand-containing
• Different kits for different therapeutic and
  diagnostic procedures
• 99mTc added for radioactivity

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Individual Doses

• Order received from hospital or clinic
• Dose drawn from radioactive kits
• Volume drawn aseptically
• Behind lead shield barrier
• Final dosage assayed in dose calibrator
• Placed in lead Pig

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Transportation

• Dose in Pig placed in lead briefcase
• Scan briefcase for safety purposes
• DOT regulates transportation

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Waste Disposal

• Time degradation is factored in
• Over time, waste becomes cold
• Cold waste treated
• Incineration
• Sterilization

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Safety

• Nuclear Regulatory Commission (NRC)
• Guidelines
• Laws
• License
• ALARA (as low as reasonably achievable) Concept

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Diagnostic Uses

• Brain Imaging
• CSF Imaging
• Bone Imaging
• Cardiac Imaging
• Pulmonary Imaging
• Liver and Hepatobiliary Imaging
• Renal Imaging
• Thyroid Imaging
• Tumor Imaging

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Therapeutic Uses

• Hyperthyroidism
• Palliative treatment of Bone Cancer
• Non-Hodgkins Lymphoma

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In Vivo and In Vitro Testing

• Red Blood Cell Labeling
• Uses include
• GI blood loss studies
• Blood pool studies
• Spleen Imaging

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PETPositron Emission Tomography

• Generate radioactivity in nuclear reactor
• Manufacture radiopharmaceutical
• Shows both anatomy and physiology
• Shorter half-life than traditional
  radiopharmaceuticals

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How to become a Nuclear Pharmacist

• Must be a RPh.
• Complete nuclear certification training
• University-based
• Purdue University
• The Ohio State University
• Company-based
• Cardinal Health

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Benefits of Nuclear Pharmacy

• No customers or drive-thrus
• Relaxed working environment
• Low Pharmacy Technician turnover
• Variety of duties opportunities for pharmacists
• Responsive management
• Top benefits and excellent pay

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Nuclear Pharmacy Elective

• Site visits
• Nuclear Pharmacy
• Hospital Pharmacy
• PET NET
• Independent learning
• Interesting topic

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Questions