Hyperplasia and hypertrophy of Smooth muscle in asthma

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Busselton Population Medical Research Foundation
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Vancouver
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Calgary
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London
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Where is Busselton?
The Shire of Busselton is the target population
of the Busselton Health Study
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Busselton Health Studies
Cross-sectional longitudinal population health
surveys, initiated in 1966 by Dr Kevin Cullen
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Aims

• As stated in 1966
• 1. To study the prevalence of common
  diseases in an Australian community
• 2. To assess the range and variation of a
  large number of clinical and laboratory variables
  in a natural population
• To provide a community service in the detection,
  treatment and prevention of disease and in the
  education of the population
• To conduct longitudinal surveys for the study of
  risk factors related to health and disease
• To study mortality from specific diseases in an
  Australian population and to define the
  usefulness of risk factors in predicting such
  mortality

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Methods used in Busselton1966 - 2007
Standardised Questionnaires
Spirometry
Bronchial challenges
Histamine
Methacholine
Skin Allergy Tests
Dust mites Grasses Cat/dog Mould
Atopy
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Dataset

• Over 16, 000 participants since 1966
• Biological specimens
• Sera
• DNA
• Physical data
• Anthropometry
• Lung Function
• Atopy allergy
• Cardiovascular function
• Mental health cognition

• Lifestyle Behaviour
• Nutrition
• Alcohol Tobacco use
• Exercise
• Mortality Hospital Admissions
• Linkage via WA Hospital Morbidity Data System
• Family data
• 2000 families

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Recent Projects

• Asthma Prevalence Study (2005-07)

Burden Of Lung Disease (BOLD) (2007-08)
2929 adults 1500 school-aged children
629 Busselton Adults gt 40 yrs of age
Obesity, Metabolic Syndrome, CVD Risk Study
(2006-08)
Sleep-Disordered Breathing Study (2007- ongoing)
500 children adolescents 1200 adults
gt800 adults
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Current Projects

• The Busselton Diabetes Study (BDS) (2008 - 2009)

Regional comparision with Fremantle Diabetes
Study (FDS II) 250 Diabetics and
250 age-matched controls

• Anthropometry
• Biochemistry
• Neurological assessments
• Vision
• Blood pressure
• Brachial-Ankle Index
• ECG
• Spirometry
• Oximetry
• Sleep Apnoea
• Diet Nutrition
• Quality of care
• Lifestyle well-being

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Current Projects

• The Busselton Healthy Ageing Study (BHAS)
  (Commencing 2009)

Multidisciplinary focus on diseases
and factors common to ageing 3000 Baby Boomers
45 64 year olds

• Anthropometry
• DEXA scans bone, muscle, fat
• Cardiovascular profiling
• Muscle strength balance
• Physical Activity
• Eyes vision
• Ears hearing
• Respiratory function health
• Cognition
• Diet nutrition
• Mental health well-being
• Biochemistry DNA

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Genetic Studies (Asthma and Allergy) Using
Busselton Data Association Studies - Cookson
(London), Palmer and others.
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BPMRF Investigators

Clin Prof Bill Musk    Respiratory diseases
Assoc Prof Alan James Respiratory diseases/ pulmonary physiology
Prof Mathew Knuiman Biostatistician/epidemiologist
Prof Lyle Palmer Genetic epidemiology
Assoc Prof Joseph Hung Cardiovascular diseases
Adj Prof John Beilby  Laboratory scientist, cardiovascular studies
Dr Digby Cullen  Gastroenterology
Dr Tim Welborn Diabetes, obesity
Prof Timothy Davis  General medicine, diabetes
Adj Prof Nicholas de Klerk Biostatistician/epidemiologist
Dr Peter Hollingsworth Laboratory scientist, immunology
Dr Jennie Hui Genetics
Dr Brendan McQuillan Cardiovascular diseases
Prof John Olynyk Gastroenterology, liver disease
Prof David Ravine Medical genetics
Clin Assoc Prof John Walsh Thyroid diseases
Dr Bu Yeap Endocrinology
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• Strengths
• Numbers, Longitudinal Cross-sectional,
• Phenotypes (Q, airway function, blood), Family
  linkage.
• Resources
• Genotyping, Staff, Infrastructure (some).
• Collaborative areas
• Respiratory and Allergy, CVD, Diabetes

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British Columbia
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Western Australia