bacillary dysentery, shigellosis

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HCV EPIDEMIOLOGY AND PREVENTION IN CHINA
ZHANG JUANJUAN PROJECT MANAGER
GLOBAL AIDS PROJECT BEIJING
ZHAO DONGHUI MASTER OF PUBLIC HEALTH
HEILONGJIANG CDC NORTHEAST CHINA
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HCV EPIDEMIOLOGY AND PREVENTION IN CHINA

• Overview of HCV Epidemiology in China
• Introduction to Chinese Clinical HCV Diagnosis
  and Treatment Standards
• Strategies Adopted in Present HCV Prevention and
  Treatment in China
• Challenges Facing HCV Prevention and Treatment.

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Overview of HCV Epidemiology in China

• HCV infected rate among general pulation in
  China was 3.2
• the estimated infected persons were more than 30
  million
• Infected rate was different between area and age
• Infected rate no different between gender

( ??????????????? 19921995 )
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The provincial distribution of anti-HCV
prevalence rate in general populationChina
mainland
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The provincial distribution of anti-HCV
prevalence rate in general China mainland
( ??????????????? 19921995 )
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Tab. Age specific prevalence of anti-HCV by sex
in Beijing
( ??????????????? 19921995 )
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Regional distribution of HCV main genotypes in
China
Wang Y, et al. J Med Viral,
1993,40254-260 Zhuang H , et al.????????,
2001,2299-101
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HCV infection among IDU in China
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• Regional distribution of pooled prevalence of HCV
  infection among injection drug users in China

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Co-infection of HCV, HBV and HIV among IDUs
??,??,???. ????????????????????. ???????? 2007
15( 27)2966-71
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2008 HCV investigation in China

• HCV infection situations and situations of HIV
  and HCV co-infection among Target group
• Combined existed HIV surveillance sites and other
  resources
• 31 provinces and regions being covered
• Target groupIDUs?STD client?MSM?females serving
  in places for amusements ?HIV positive

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The investigations among MSM in four cities of
Heilongjiang

• 2008 Apr. July
• 1,353 case
• Sampling methods RDS and Snowball rolling
• HCV screening Shanghai's third generation HCV
  ELISA

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The investigations among MSM in four cities of
Heilongjiang

• 1353 case
• the age median is 26.0
• 78.2 were married and 21.8 were unmarried
• 60.6 of them were gays, 32.7 were bisexual and
  3.3 heterosexual
• found their partner mainly through the Internet,
  and 24.0 in bars, 20.7 in bathhouses and 10.8
  in parks or lavatories

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The investigations among MSM in four cities of
Heilongjiang

• First sexual intercourses is 20
• During the past 6 months, 83.8 (1,134/1,353)
  anal intercourses with males
• the non-protection rate is 55.4 (628/1,133)
• 56.7 have more than 2 male partners
• 7.5 (85/1,134) had sex for commercial purposes
• the non-protection anal intercourse rate is
  44.7 (38/85)
• During the recent 6 months, 22.1 (299/1,353)
  have had sex with female
• non-protection being 70.2 (210/299)
• during recent 6 months, 0.9 (12/1,353) taken
  drugs
• 0.5 (6/1,353) of them through injections
• 15.1 (204/1,352) of the samples had symptoms of
  sexual diseases during the past 1 year.

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HIV, syphilis and HCV infections among MSM
syphilis ()
HIV ()
HCV ()

Cases
Harbin
Qiqihaer
Jiamusi
Mudanjiang
Total
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HCV infection in other target group

• 6,052 females serving in amusement facilities,
  the highest HCV infection rate is 1.5, averaging
  0.5
• 52 HIV positive through sex, 20 have abnormal
  liver functions

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Initial conclusion about the investigations

• Sex efficiency is low
• MSM no higher risk than heterosexuals
• to prevent HCV from sexual transmission can not
  be overlooked
• Indicate that the general public in China may
  exist a dropped infection rate?

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HCV Diagnosis and Treatment Standards in China

• the Plan on Prevention and Treatment of Viral
  Hepatitis in 2000
• the Prevention and Treatment Guide of Hepatitis
  C in March 2004
• Chinese Medical Association
• The Liver Disease Branch and Infectious Disease
  Branch
• referring APASL?NIH?EASL recommendations

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HCV Prevention Strategies in China

• To guarantee blood safety and control HCV blood
  transmission
• Strengthening the supervision and management over
  the disinfection operations in hospitals
• Integrated HIV and HCV prevention resources

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Challenges Facing HCV Prevention and Treatment in
China

• To raise public awareness about HCV
• To establish the case find-transfer-treatment
  system
• To raise treatment accessibility and effects
• the problem of anti-HCV window period
• HCV discrimination
• Chinese medicines to play an active adjuvant 
  role

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