Nanomaterialer

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Nanomaterialer udgør de et miljø- og
sundhedsmæssigt problem?

• Steffen Foss Hansen, Laura Roverskov Heggelund,
  Pau Revilla Besora, Aiga Mackevica, Alessio
  Boldrin, Anders Baun

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Nanoproducts

• Unclear what is on the marked
• Unclear what consumers are exposed to
• Unclear how much consumers and the environment is
  exposed to
• Hampers quantitative consumer exposure assessment
  

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The Nanoproductdatabase (www.nanodb.dk)

• 2012 Initiated The Nanodatabase
• DTU Environment
• The DK Ecocouncil
• The DK Consumer Council

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NanoRiskCategorisation
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NanoRiskCat
Humans
Environment
Environment
Prof. end-users
Consumers
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High
Medium
Low
Unknown
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Determining exposure
Hansen et al. 2008 Ecotoxicology 17(5)438-447
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Examples of determining exposure
Environment

• TiO2 in sunscreen
• C60 lubricants
• CNT baseball bats

Prof. end-users
Consumers
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Human effects

• NM HARN?
• Bulk CLP?
• NM Acute tox?
• NM associated with
• CMR?
• Respiratory tox?
• CVD?
• Neurotox?
• Organ accumulation?

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Environmental effects

• Bulk CLP?
• Bulk LC50lt 10 mg/l?
• NM LC50lt 100 mg/l?
• NM T1/2 gt 40 days?
• NM BCF gt 50?
• NM dispersive?
• NM ecosystem effects?
• NM novel?

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CNT - HARN, Ecotox lt 100 mg/l, T1/2 gt40 d

• Human effects

• Environmental effects

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Consumers
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Environment
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Humans
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Environment
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Do Your Own Analysis!
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Limitations

• Based on nano-claims
• Yes, but we cannot a this point do independent
  validation
• Products are all red
• Could seems so, but they turn red for different
  reasons (HARN vs. CMRs)
• Crude hazard assessment
• What do you mean?
• Crude exposure assessment
• Yes, but the producers do not provide information
  that would enable more detailed exposure
  assessment

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Tools for nanoparticle characterization

• Single Particle ICP-MS
• Size distribution
• Particle number concentration
• Particle mass concentration
• Dissolved metal concentration
• Chemical composition
• Transmission Electron Microscopy (TEM)
• Particle shape
• Agglomeration/aggregation
• Size

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Silver nanoparticle release from toothbrushes
106 particles/L
106 particles/L
http//www.aliexpress.com http//www.beautyofnewyo
rk.com
Mackevica et al. (in prep.)
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Tiede et al. 2015

• Aim
• Identified types of NPs likely to reach water
  sources
• Method
• Derived worst case concentrations of NPs in raw
  water and treated drinking water
• Used simple exposure model
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• Results
• Titanium oxide-, zinc- and silicon-based NPs
  likely to be found in the highest concentrations
  in treated waste and drinking waters
• Carbon-based (C), iron oxide and silver
  nanoparticles rank in positions 6, 7 and 8,
  respectively
• Worst case predicted concentrations in drinking
  waters were in the low- to sub-?g/l range and
  more realistic estimates were tens of ng/l or
  less.

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Funding

• Thank you very much
• DK EPA (2010-2011)
• Villum Foundation (2012-2014)
• EnvNANO (2013-2015)
• SUN (2014-2015)
• DEFRA

This work is part of the project ENVNANO
(Environmental Effects and Risk Evaluation of
Engineered Nanoparticles) supported by the
European Research Council (grant no.
281579). This project has received funding from
the European Unions Seventh Framework Programme
FP7/2007-2013 under EC-GA No. 604305 SUN
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Thank you for your Attention!
?sfh_at_env.dtu.dk