THE ARTEPAL PROJECT

1
THE ARTEPAL PROJECT

• TO IMPROVE THE AVAILIBILITY
• OF ACT

2
ARTEPAL1/ THE PROJECT

• PROJECT OF AEDES FOUNDATION
• Agreed and financed by E.U. on 3 years
• 3 sections technology transfer, pregnant women,
  distribution
• Oteci (senior-experts) in charge of technology
  transfer under control of a technical and
  scientific committee.
• OBJECTIVE IMPROVE AVAILIBILTY OF ACTs

3
ARTEPAL2/SITUATION

• Evaluation of projects in all the supply chain
  (plantations, extraction, pharma) and in
  different regions
• Evaluation of extraction processes
• Establishing connections between different
  partners
• Support in GMPs at different levels in connection
  with WHO/pre-qualification.

4
ARTEPAL3/ FINDINGS

• Numerous projects restarting basic studies
  available in the literature
• Numerous plantation projects without available
  extraction unit.
• Numerous projects without knowledge of the
  commercial possibilities and quality requirements
• Numerous questions asked to WHO/RBM/MMSS and
  others

5
ARTEPAL3/FINDINGS

• Since the meeting in Arusha, risks of
  inadaptation of demand and supply are increasing.
• Quantities
• Quality
• Recommandation of WHO for only ACTs may deeply
  change the demand

6
ARTEPAL4/PROPOSAL S

• WHO/RBM/MMSS with MSH/RPM Plus intend to produce
  a guide to API production covering
• Cultivation issues on artemisia annua
• Seeds sourcing, quantities needed
• Planting, growing conditions, climate
• Areas of cultivation and surfaces
• Major issues, agricultural and financial
• Average biomass and artemisini content

7
ARTEPAL4/PROPOSALS

• Production of Artemisinin
• Extraction units
• Where
• Capacity, quantity and time of production
• Kind pf process
• Possibilities to extract other products
• Constraints technical, financial
• Issues involved with respect to the quality of
  finished ACTs
• GAP
• GMP
• DMF

8
ARTEPAL4/PROPOSALS

• Main deliverable
•  Market analysis of the current situation in
  terms of capacity, quality issues,..
• A guide for resources, contacts
• Table or tool to estimate cultivation and
  extraction needs across the production chain.