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Ecstasy Damages Brain Serotonin Neurons

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Ecstasy Damages Brain Serotonin Neurons Presented by Michelle Dupre Biology Department Eastern Connecticut State University Positron emission tomographic evidence of ... – PowerPoint PPT presentation

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Title: Ecstasy Damages Brain Serotonin Neurons


1
Ecstasy Damages Brain Serotonin Neurons
  • Presented by Michelle Dupre
  • Biology Department
  • Eastern Connecticut State University

2
Positron emission tomographic evidence of toxic
effect of MDMA (Ecstasy) on brain serotonin
neurons in human beings.
  • Article written by
  • U.D McCann, Z. Szabo, U. Scheffel, R. F. Dannals,
    G. A. Ricaurte
  • The Lancet 1998 352 1433-37

3
What do we know about Ecstasy?
3,4-methylenedioxymethamphetamine
Popular drug at raves, clubs, homes
4
Transport of serotonin
5
Previous findings
Animals show losses in serotonin markers
Doses parellel human doses
Previous studies use cerebrospinal fluid
6
Positron Emission Tomography (PET)
Neuroimaging technique
Attaches to face masks
11C Labels serotonin transporter
Detects status of neurons in the brain
7
The Experiment
  • Experimental group
  • Control group
  • PET scanning

8
What were they looking for?
1) Differences in serotonin transport sites.
2) The relationship between MDMA use and binding.
3) Overall brain activity
9
What did they find?
MDMA users have lower densities of 5-HT
transporter sites.
Direct relationship between MDMA use and decrease
in 5-HT binding.
10
What does this all mean????
11
DEATH
16 years old
23 years old
18 years old
12
Any Questions?
13
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