The Complement Cascade

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The Complement Cascade

• The Terminal Pathway

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C3b
C5
Next
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Complement The Terminal Pathway
C5b
C5b binds to C6
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Complement The Terminal Pathway
C5b.6
C5b binds to C6
Next
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Complement The Terminal Pathway
C5b.6
C5b.6 binds to C7
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C5b.6.7
C5b.6 binds to C7
Next
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C5b.6.7
C5b.6.7 binds to C8
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C5b.6.7.8
C5b.6.7 binds to C8
Next
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C5b.6.7.8
C5b.6.7.8 binds 12-15 molecules of C9 to form the
Membrane Attack Complex
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C5b.6.7.8.9n
C5b.6.7.8 binds 12-15 molecules of C9 to form the
Membrane Attack Complex
Next
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Complement The Terminal Pathway

• The following slides are a graphical illustration
  of the terminal pathway
• The end-point is the formation of the membrane
  attack complex which punches a hole in the
  bacterial membrane.
• This loss of membrane integrity results in the
  death of the bacteria
• The graphics run automatically

Next
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Complement The Terminal Pathway
cell membrane
pathogen
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C5b
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C6
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C7
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C8
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C9
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Complement The Terminal Pathway
The Membrane Attack Complex
End of Presentation