The Autonomic Nervous System

1
The Autonomic Nervous System
2
Autonomic control areas in the brain stem and
hypothalamus
3
(No Transcript)
4
Sympathetic Nerve Fibers in the Skeletal Nerves
5
Prevertebral (Collateral)
Celiac (Solar plexus) Sup. Mesenteric Inf.
Mesenteric Pelvic-hypogastric plexus Adrenal
medulla sympathetic prevertebral
ganglion Amplification Slower to arrive Slower to
dissipate Lack the point to point specificity of
other SNS projections
6
Parasympathetic
7
Points Sympathetic Parasympathetic
Functions Catabolic Anabolic
Location of Ganglion Distant from target organ Near or in target organ
Length of preganglionic axon Relatively short Relatively long
Divergence of preganglionic axonal projection One to many One to few
Innervate trunk and limbs in addition to viscera Yes No
Postganglionic transmitter NE Ach
8

• Ach receptors
• Nicotinic
• Ion channel receptor (Na and K) N1, N2
• Muscarinic
• G protein-coupled receptor
• M1, M3, M5 (PLC)
• M2, M4 (inhibition of AC)

9
(No Transcript)
10
(No Transcript)
11
Co-tranmission

• ATP and neuropeptide Y co-release with NE.
• VIP with Ach
• In ganglions
• Ach- N2- rapid EPSP
• Ach- M- slow EPSP

12
Termogenesis (ß3)
13
(No Transcript)
14
(No Transcript)
15

• Components of autonomic reflexes arcs
• sensory receptor sensory neuron
  integrating center pre postganglionic motor
  neurons visceral effectors

16
Horner's syndrome