Investigation: Molecules to Man (and back)

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Investigation Molecules to Man (and back)
Robert P. Kimberly, M.D. Howard Holly Professor
of Medicine Senior Associate Dean for
Research Director, UAB Arthritis and
Musculoskeletal Center
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Investigation M2M and back

• How to establish a career

Identify a mentor, and have a coffee at
least once a month
Organize your lab, and dont hesitate to use
the HHMI website
Understand the expectations for promotion
Research productivity Teaching performance
Service (resource, admin, clinical)
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Investigation Identify a mentor

• Lucy's Coffee Tea2007 University
  Blvd.328-2007In addition to coffee and tea,
  Lucy's offers sandwiches, salads, baked goods and
  more at good prices. Warm, friendly atmosphere,
  retro furniture and funky artwork. City Scene
  gave high marks to the smoked turkey sandwich,
  with smoked gouda, tomato chutney and arugula,
  served on toasted ciabatta bread from Edgar's
  Bakery.

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Investigation Organize your lab

• HHMI Making the Right Moves, A Practical Guide
  to Scientific Management for Postdocs and New
  Faculty (http//www.hhmi.org/resources/labmanagem
  ent/index.html)
• Staffing your lab
• Mentoring
• Getting funded
• Project and data management
• Setting up collaborations
• Publications
• Technology transfer

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Investigation Organize your lab

• Occupational Health Safety - radiation safety,
  chemical safety, etc. (http//www.healthsafe.uab.e
  du/)
• Use of Animal Subjects general information and
  species specific training (http//www.uab.edu/iacu
  c)
• Use of Human Subjects initial training and
  continuing education(http//www.uab.edu/irb)
• Effort Reporting (http//main.uab.edu/show.asp?dur
  ki79361)

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Investigation Organize your lab

• Mandatory certifications
• UAB Code of Conduct
• (http//www.hrm.uab.edu/codeofconduct)
• HIPAA
• (http//www.hipaa.uab.edu/training.htm)

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Investigations Organize your lab
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http//main.uab.edu/research

• Administration and Oversight
• Animal Resources Program (ARP)
• Office of Research Compliance (Clinical Trials)
• Conflict of Interest Review Board
• UAB Fincial Affairs (Grants and Contracts
  Accounting)
• Institutional Animal Care Use Committee (IACUC)
  
• Institutional Review Board (IRB) for Human Use
• Occupational Health Safety
• Office of Grants and Contracts Administration
  (OGCA)
• Office of Research Compliance
• Office of Sponsored International Programs (OSIP)
  
• Research Foundation (UABRF)
• University Counsel Office

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http//main.uab.edu/research

• Facilities
• Alabama Department of Public Health (ADPH)
• Birmingham Regional Emergency Medical Services
  System (BREMSS)
• Birmingham Veterans Affairs Medical Center
  (BVAMC)
• Centers at UAB including those based in
  departments and schools
• Jefferson County Department of Health (JCDH)
• Center for Clinical and Translational Science
  (CCTS) Clinical Research Unit (CRU)
• Southeast Biosafety Laboratory Alabama Birmingham
  (SEBLAB)
• Southern Research
• UAB Health System Facilities

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http//main.uab.edu/research

• Forms
• Animal Resources Program(ARP) Forms
• Conflict of Interest Review Board (CIRB) Forms
• Financial Affairs (e.g., Accounting) Forms
• Institutional Animal Care and Use Committee
  (IACUC) Forms
• Institutional Review Board for Human Use (IRB)
  Forms
• Occupational Health and Safety (OHS) Forms
• Office of Grants and Contracts Administration
  (OGCA) Forms
• UAB Research Foundation (UABRF) Forms

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http//main.uab.edu/research

• Graduate and Postdoctoral Training
• International Research Training Programs
• Office of Postdoctoral Education
• The Graduate School
• Technology Transfer and Economic Development
• Innovation Depot - Office for the Advancement of
  Developing Industries (OADI)
• UAB Research Foundation
• UAB Research Park at Oxmoor

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http//main.uab.edu/research

• Regulatory Training
• BlazerNET (http//blazernet.uab.edu)
• Blazer ID and PW to log in.
• Research Tab- Check compliance courses taken
• Effort Reporting
• Diversity Training
• HIPAA Training
• IACUC Training
• OHS Training
• IRB Training

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http//medicine.uab.edu/research/
Faculty Development Resources UAB core facilities
Budget and grant writing links Funding
opportunities Compliance
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Investigation Expectations

• Research Productivity
• How to choose an area for investigation

Think broadly the NIH Roadmap
Look at UAB UWIRC Centers
Look for translational opportunities
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Investigation Expectations
Research Productivity Funding

• Government Resources (www.grants.gov)
• Federal
• State
• Private Resources
• Foundations and Associations
• Nonprofit Centers
• Charities
• Internal Funding University Sponsored

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Investigation Expectations

• NIH resources for new investigators
• http//grants.nih.gov/grants/new_investigators/res
  ources.htm
• Identify appropriate individual NIH career awards
  by using the wizard
• http//grants.nih.gov/training/kwizard
• All about grants - Tutorials
• http//www.niaid.nih.gov/ncn/grants/default.htm
• Annotated grant
• Annotated summary statement

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NIH Small Grant Program (R21)

• New, exploratory and developmental research
  projects
• Supports early stages of project development
• May involve considerable risk but may lead to a
  breakthrough in a particular area, or to the
  development of novel techniques, agents,
  methodologies, models or applications that could
  have major impact on a field of biomedical,
  behavioral, or clinical research
• Should break new ground or extend previous
  discoveries toward new directions or applications

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Associations Foundations

• American Heart Association
• American Lung Association
• American Cancer Society
• Arthritis Foundation
• Howard Hughes Medical Institute
• National Marfan Foundation
• Ellison Medical Foundation
• Cystic Fibrosis Foundation

• The Alzheimers Association
• FRAXA Research American Heart Foundation
• American Diabetes Foundation
• Leukemia and Lymphoma Society.
• Juvenile Diabetes Research Foundation
• National Neurofibromatosis Foundation
• Coulter Foundation

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UAB Nominates Candidates

• Ellison Medical Foundation (Aging)
• The John Merck Fund (Developmental Disabilities
  in Children)
• The W. M. Keck Foundation's Distinguished Young
  Scholars in Medical Research
• Pew Scholars Program
• Burroughs Wellcome Biomedical Scholars
• Howard Hughes
• Daymon Runyon Foundation
• Searle Scholars

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Investigation updates on funding

• Join the UABRADM listserve
• (http//www.uab.edu/uabra/uabradm_request.htm)
• Join the Community of Science - keep your
  biosketch updated!
• (www.cos.com)
• Subscribe to the NIH NEXUS Listserve
• (http//grants.nih.gov/grants/nexus.htm)
• Search
• (www.grants.gov)
• Talk to your colleagues

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The Independent Investigator

• Publishes in high quality journals in a given
  area
• Serves as a principal investigator of grants or
  contracts
• Significant and sustained extramural funding
• Supervises graduate students, post doctoral and
  clinical fellows
• Initiates and participates in research
  collaborations

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Investigation M2M and back

• How to establish a career

Identify a mentor, and have a coffee at
least once a month
Organize your lab, and dont hesitate to use
the HHMI website
Understand the expectations for promotion
Research productivity Teaching performance
Service (resource, admin, clinical)