??? ? ? (nucleolus)

1
??? ? ?(nucleolus)

• ????????
• ??????
• ?????

2

• ?????
• ????????,??,????,????,?rRNA??????,???????
  ???????

3
?????????

• ?????(fibrillar centers, FC)
• ???????(dense fibrillar component, DFC)
• ?????(granular component, GC)
• ????????(??????????????)
• ????(??DNA?RNA??????)

4

• Nucleolus

5

• ? ????????????
• (fibrillar center)
• FC????????????????????????,?????RNA????rDNA,
  ??rDNA?????????DNA??????rRNA,??????rRNA???????????
  ??,???DNA???????(nucleolar organizer)????DNA???10?
  ???????????????????? NOR(nucleolar organizer
  region)?

6

• ? ????????????????
• (dense fibrillar component)
• ?????????FC,????????,?????????????
• ???????,?rDNA??????????

7
? ?????????????

• (granular component)
• ?RNA??????????????????15-20nm?????,??????
  ???????(RNP)?????
• ??,????????????????????

8
?????????rRNA????????RNP???????

• ? FCs?rRNA???????
• ????????FC? DFC????,
• ????????
• ??????(GC)????????
• ??,????????????????

9
(No Transcript)
10
???????

• ????????(ribosome biogenesis)?
• ??????(vetorical process)?????
• ????, ?????????
• ??????rRNA?????????
• ????????
• ? rRNA????????????
• ? rRNA?????
• ??????????

11
rRNA????????????

• ?????
• ??NORs?rDNA?rRNA??????
• ????????????
• ?rRNA?????????????????

12
rRNA?????

• ?????
• ???????
• ??????RNA(snoRNAs)???????????(snoRNPs)
• ???RNA(guide RNA)

13
?????????

• ????????????RNA???
• ???,??????????????
• ??????????????????
• ???, ??????????????
• ??????hnRNA????
• ???????????mRNA???????

14
????????????rRNA???10????????????????
15
(No Transcript)
16
rRNA?????
17
(No Transcript)
18
rRNA???
19
(No Transcript)
20
??????
21
(No Transcript)
22

• ????????
• ????????rRNA?????
• ????rRNA???????
• ??rRNA?????????45S rRNA,?????,??28S rRNA?
  18S rRNA?5.8S rRNA???,????????????5S?rDNA???
• ????????????????
• ???????,?????????????,????RNA???????????????
  ???

23
??????

• ????????
• ?????????????rDNA????????????

24
Thank you!
25
???????????