Diapositiva 1

1
The cellular membrane
Gaetano Pezzicoli
Agorà Biomedical Science School - Lesina (FG),
Italy
2
Cell
cellular membrane
nucleus
organuls
citosol
3
Membrane structure
Glicoprotein
Protein
cholesterol
phosphate
lipide
4
Membrane funtions
Cellular membrane
funtions

• filter

• interaction

• comunication

• recognition

5
Filter funtion
passive filter
active filter

• normal

• primary

• facilitate

• secondary

• eso-endo-citosis

6
filter funtion
passive filter
active filter

• normal

• primary

• normal

• Facilitate

• secondary

• Eso-endo-citosis

7
Passive normal filter








8
filter funtion
passive filter
active filter

• normal

• primary

• Facilitate

• secondary

• facilitate

• Eso-endo-citosis

9
Passive facilitate filter








Channel proteine
10
Passive facilitate filter







carrier protein

11
filter funtion
passive filter
active filter

• normal

• primary

• primary

• Facilitate

• secondary

• Eso-endo-citosis

12
Active primary filter



ATP



pump protein


13
filter funtion
passive filter
active filter

• normal

• primary

• Facilitate

• secondary

• secondary

• Eso-endo-citosis

14
Active secondary filter












pump protein
15
filter funtion
passive filter
active filter

• normal

• primary

• Facilitate

• secondary

• Eso-endo-citosis

• Eso-endo-citosis

16
Eso-endo-citosis

cellular membrane
macromolecule
17
Comunication funtion
Depolarization process
18
A-
A-
A-
A-
k
k
k
k
k

A-
A-
A-
A-
k
k
-
k
k
k
A-
A-
A-
A-
A-
A-
A-
A-

-
Na
Na
Na
k
Na
Na
Na
k

pump proteins
k
-
Na
Na
k
k
Na

-
Cl-
-
Cl-
-
-
Cl-
Cl-
19
A-
A-
A-
A-
k
k
k
k
k
A-
A-
k
k
A-
A-
k
k
k
A-
A-
A-
A-
A-
A-
A-
A-
Na
Na
Na
k
Na
Na
Na
k
k
k
k
Na
Cl-
Cl-
Na
Cl-
Cl-
Na
20
A-
A-
A-
A-
k
k
k
k
k
A-
A-
A-
A-
k
k

k
k
k
A-
A-
A-
A-
A-
A-
A-
A-
k

cellular dead
alarm
k
k
Na
Na
Na

Na
Na
Na
k
Na
k
Na
Na

-
-
Cl-
Cl-
-
-
Cl-
Cl-
21
A-
A-
A-
A-
k
k
k
k
k
A-
A-
A-
A-
k
k
-
k
k
k
A-
A-
A-
A-
A-
A-
A-
A-
-
k
out danger
k
-
k
k
Na
Na
Na
k
Na
Na
Na
-
Na
-
-
Cl-
Cl-
Cl-
Cl-
Na
Na
-
-
Cl-
Cl-
Cl-
Cl-
22
A-
A-
A-
A-
k
k
k
k
k
A-
A-
A-
A-
k
k
k
k
k
A-
A-
A-
A-
k
k
k
k
k
A-
A-
A-
A-
Na/Cl pump proteins
Na
Na
Na
Na
Na
Na
Cl-
Cl-
Na
Na
Cl-
Cl-
23
Recognition funtion
Immunitary system
24
cells
linfocite
bacterium
HLA
25
Natural killer