????:??? hypothalamus

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??????????????
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???????????

• ?????????
• ????
• ??????????
• ????
• ???

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(No Transcript)
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?????????????

• ??????? hypothalamus
• ???????? NAc, nucleus accumbens
• ?????nucleus of the solitary tract (NTS)

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??????

• ???lateral hypothalamic nucleus(LHA)????
• ??????arcuate nucleus (ARC)
• ???paraventricular nucleus (PVN)
• ????Ventromedial nucleus (VMH)
• ????Dorsomedial hypothalamus (DMH)
• ????, perifornical area (PFA)

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(No Transcript)
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????????????

• ???Y(neuropeptide Y,NPY)
• ????? agouti-related peptide(AgRP)
• ???,??????????cocaine- and amphetamine-regulated
  transcript (CART)
• ????(Melanocortins)??Adrenocorticotrophin?melanoc
  yte-stimulating hormones(MSHs)?melanin-concentrati
  ng hormone (MCH)
• ?????????brain-derived neurotrophic factor( BDNF)
• ????????(corticotrophin-releasing hormone, CRH)
• ?????????(thyrotropin-releasing hormone TRH)
  pro-opiomelanocortin (POMC)
• ???(???)Orexin A and B

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(No Transcript)
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?????????
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???????

• Leptin(??)-ob????,?????????,????????????
• Insulin(???)?????????
• Adiponectin(???)??????
• Resistin(???)???????
• Visfatin(???)????????,???B????????(pre-B-cell
  colony-enhancing factor,PBEF),????????????????????

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??????????????
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leptin

• Ob????,?????????,??????????????
• ???????????????
• ?????????leptin,??????,??????
• ??leptin???????????,????
• ?????????,??????,
• ????????

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insulin

• ??ß????,?????????
• ????????????,????????????
• ???????????
• ????????
• ??????????????
• ?????insulin??

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Adiponectin

• ??????
• ??????,????
• ???????????,??????
• ?insulin?????
• ??????????,??????????????????????

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????

• ??????(Ghrelin)
• ???(Gastrin)
• PP???PP-fold peptides include PYY, PP
• ????cholecystokinin (CCK)
• ???????glucagon-like peptide 1 ?2(GLP-1,GLP-2)
• ??????oxyntomodulin (OXM)

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Ghrelin

• ??????
• ??????,???
• ????,????????
• obestatin ghrelin???,?ghrelin????????,???????

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???????????
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???????
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????????????????
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??????????????????
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?????????????????
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????

• PYY???????,??????,?????
• PP????????????
• GLP-1?GLP-2????,????,?????????
• OXM??ghrelin??,????,????????,????
• CCK???????????,???????????,???????,??????,?????

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proglucagon gene

• Glicentin
• oxyntomodulin (OXM)
• GLP-1
• GLP-2

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oxyntomodulin (OXM)

• ?????GLP-1??,????,?????????
• ??ghrelin??,????
• ??insulin??,??????
• ???????????,??????,???????
• ?????????????????

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?????????
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??????

• ???????
• ????
• ????????????????????
• ????

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??????
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????????

• ???????????????
• Leptin?insulin???????
• ???????????
• ??????
• ???????????????

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???????

• ????????????????????????,????????????????,???????
  ?,????
• ????????,???????????????????(Sibntramine)?????????
  
• ???????????

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???????????

• ????(orlistat)(???Xenical,???),????????? ,???????
• ??????????????
• ?????????????,??????

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????

• ?????????(???????)?

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???

• ????,????????????????????????? ,????
• ????,????,???,???????,???? ,????,?????

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????

• ????Leptin(??)?Insulin(???)?Adiponectin(???)?Visf
  atin(???)
• ????
• PP?PYY, PP
• GLP-1,GLP-2
• ??????oxyntomodulin (OXM)

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? ?