?????????????????Runx2?????????????

1
?????????????????Runx2?????????????

• ??? ?? ?? ???
• ?????????????????????

2
????

• ?????(extracellular matrix,ECM)
• ????????
• ??????????
• ECM????????????
• ???????????
• ????????????????????ECM??
• ECM??????????
• ????????ECM????????
• ????????????
• ????????????
• ?????
• ???
• ????????

3
??????

• ECM????????????????(runt-related transcription
  factor 2, Runx2)??????
• Runx2
• ????6p21
• ????
• ????,???????ACCACAxA(x?????)
• ?????????????
• ?????????????????
• ??????WNT?MAPK?PI3K?BMP/SAMDs?
• ????????p21,RANKL,MMP2,MMP9,MMP13,VEGF,OP?BSP?

4
????

• ??Runx2?ECM?????????
• ??????????Runx2?ECM???????

5
????
????
??????
??????
ChIP
???????
??????
6
????

• Runx2??ECM??????(52?)
• ECM??11?
• ECM???????8?
• ??????33?
• Runx2??????????(19?)?????Runx2????
• 4?????WNT????
• 3?????TGF/BMPs????
• 4?????????
• 8?G??????
• Runx2??????????(33?)??????Runx2????
• 11?ECM??
• 8?ECM???????
• 14?????

7
Runx2???????????

• PubMed??????????
• ????????SFRP2?TIP-1?DKK3?FST?FSTL1?CKTSF1B1
• ??????ECM??????COL10A1?ECM2?OSF-2?COL1A1?MMP13
• ?????????????
• SB-431542??TGF/BMPs?????,Runx2?????
• ChIP????COL11A1??????Runx2???????

8
Runx2???ECM?????????
9
??

• Runx2????????
• Wnt????
• Wnt???Fzd???LRP 5/6??????,????DSH?????,??CTNNB1???
  ????,CTNNB1????,??????,???????T????TCF/LEF??,??Run
  x2?????
• WNT2?SFRP2?TIP-1?DKK3?Wnt?????????
• TGFB/BMPs????
• BMPs/TGF?-Smads?????????Runx2?????SMID/NMTS???,??R
  unx2?????
• FST?FSTL1?CKTSF1B1??TGFB/BMPs????
• Runx2???????ECM??????
• ECM??????COLs?OSF-2?ECM2?MMP13?TIMP2?MMP9?MMP13?

10
??

• WNT?TGF/BMPs???Runx2?????????
• Runx2??????ECM???ECM???????????????ECM??,?????????
  ??????.

11
??!