Diapositiva 1

1
Universidad Autónoma de Nuevo León Hospital
Universitario Dr. José E. González Servicio de
Geriatría
BMI, Albumin, Hemoglobin and Alzheimers Disease
González Blanca M.N. Gámez Daniel M.D. Salinas
Ricardo M.D. Ortiz Xochitl PhD.
Presented on July 8th 2009 IAGG Congress
Paris 2009 Introduction Studies had shown a
decline in serum albumin levels in patients with
Alzheimers disease. The objective of this study
is to show the changes of the albumin and
hemoglobin levels in 30 patients diagnosed with
Alzheimers disease, during a one year period.
  Methods and materials This is an
observational, descriptive, prospective study.
The sample consisted of 30 outpatients that
fulfilled the DSM IV and NINDS-ADRDA diagnosis
criteria for Alzheimers disease. Three visits
were performed at 0, 6, and 12 months. Body mass
index (BMI), albumin and hemoglobin (Hb) were
evaluated using standard methods. Data analysis
was performed using SPSS version 13 by means of a
Pearson correlation with 0.95 confidence
interval, mean study (t student) and Anova
variable correlation.   Results The descriptive
analysis showed Sample population 30 patients,
with means of age 77.90, of educational level
6.30, of Mini Mental State Examination (MMSE)
score 12.83 (5-25). Statistical analysis
demonstrated that there is no significant change
in the levels of serum albumin and its
independent of the cognitive decline, showing the
following means V1 40.9, V2 41.2 and V3 41.3
(t 64.5, 78.6, 70.8, .000 significance). The
hemoglobin and BMI showed a decline during the
disease process with the following means Hb in
V1 134.5, V2 132.1 and V3 127.0 (t 52.9, 45.7,
33.3, .000 significance) and BMI mean V1 25.1,
V2 25.17 and V3 24.62 (t 25.2, 23.8, 18.6 .000
significance). During the correlation study
(Pearson), statistical differences were found in
Alzheimers disease, BMI and Hb and no
correlation could be determined with respect to
the albumin level. Conclusion The study showed
that the albumin level did not decline during the
Alzheimers disease process. Although a
correlation between Alzheimers disease, BMI and
Hemoglobin levels was found. We suggest new
studies to develop clinical elements that can
predict or participate as biological markers of
Alzheimers disease. Referentes   1.- Tae-Suk
Kim, Chi-Un Pae, Su-Jung Yoon, Woo-Young Jang,
Nam Jin Lee, Jung-Jin Kim, Soo-Jung Lee, Chul
Lee, In-Ho Paik, Chang-Uk Lee. Decreased plasma
antioxidants in patients with Alzheimer's
disease 2006 International Journal of
Geriatric Psychiatry 21 (4).   2. Te-Pin Ng, Lei
Feng, Mathew Niti and Keng Bee Yap Albumin,
haemoglobin, BMI and cognitive performance in
older adults Age and Ageing, May 20 2008
37(4)423-429.