Hemophilia

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Hemophilia

• By Jake Brock, Andres Navejas

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History

• First text of disease was in second century AD.
• Jewish exempt 3rd boy born in family from being
  circumcised if 2 of his older brothers died in a
  circumcision.
• Known as royal disease because Queen Victoria
  passed it on to her daughters
• In that time royalty would marry with other
  royalty often being in same family.

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What is it?

• Hemophilia is a disease in which your blood does
  not clot normally.
• Symptoms may include bleeding a lot in small
  cases, bleeding into joints is common, and
  internal bleeding could occur too.
• People can be expected to live normal lives,
  although a small percentage of people with
  disease will die from severe bleeding.
• Will be detected after a abnormal bleeding
  episode.

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More what is it

• There are two types
• Type A
• Makes up 85 of people with disease
• People lack blood clotting protein called VIII
• Type B
• Makes up 15 of people with disease
• People lack blood clotting protein called XI

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How its transmitted

• The defective gene is carried on the X
  chromosome.
• Women who are carriers have a 50 chance of
  giving it to their children.
• If the male has it in his X chromosome he will
  have to disease.
• In rare cases a mutation could occur that would
  give someone hemophilia without it being in the
  family, but overall It is a hereditary disease.

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Part of body targeted

• Mainly internal hemorrhaging in joints, muscles,
  vital organs, and especially in the brain.
• Effects blood by not allowing it to properly
  clot, which would cause people to bleed
  excessively.

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Daily life

• Your daily life will be based upon how severe
  your case of hemophilia is since it ranges from
  very mild to very bad cases.
• Light cases may not even need to much attention
  to it but being very cautious.
• Bad cases will need to replace the bad clotting
  factors, often at birth.
• Throughout the life they may need to stay on or
  take medications such as antifibrinolytic agents,
  fibrin glue, or desmopressin acetates.

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Resources

• http//www.hemophilia-information.com/history-of-h
  emophilia.html
• http//www.ncbi.nlm.nih.gov/pubmedhealth/PMH000156
  4/
• http//library.thinkquest.org/05aug/00112/hemophil
  ia_frameset.htm
• Webmd.com
• Wikipedia.com
• Photo Sources
• http//en.wikipedia.org/wiki/Red_blood_cell
• http//en.wikipedia.org/wiki/FileBlood_clot_diagr
  am.png
• http//www.lyberty.com/encyc/articles/victoria.htm
  l
• http//health.howstuffworks.com/human-body/systems
  /nervous-system/brain-pictures.htm