Hemophilia : causes, symptoms, diagnosis and treatment

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HEMOPHILIA

• CAUSES SYMPTOMS DIAGNOSIS TREATMENT

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INTRODUCTION TO HEMOPHILIA

• X-linked congeital bleeding disordercaused by a
  deficiency of coagulation factor VIII (in
  helophilia A) or factor IX (in hemophilia B).
• The deficienccy is the result fo mutation of the
  respective clotting factor genes. F8 and F9
  genes
• Frequency of approximately one in 10,000 births

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CONTINUE- INTRODUCTION TO HEMOPHILIA

• Hemophilia A is more common than hemophilia B.
  representing 80-85 of the total hemophilia
  population
• Hemophilia generally affects makes on the
  maternal side
• However, both f8 and f9 genes are prone to new
  mutations. and as many as 1/3 of all cases are
  the result of spontaneous mutation where there is
  no prior family history.

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SYMPTOMS OF HEMOPHILIA 

• The main signs and symptoms of Hemophilia depend
  upon the type of bleeding. The bleeding may be
  internal or external. Internal bleeding due to
  Hemophilia causes more complications than
  external bleeding. Symptoms of Internal
  Bleeding are
• Blood in the urine or excreta
• Bleeding in the intestine, stomach or kidneys
• Bleeding in the knees, elbows, and other joints

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CONTINUE SYMPTOMS OF HEMOPHILIA

• Symptoms of External Bleeding are
• Excessive bleeding from minor injury
• Bleeding of gums
• Nose bleeding
• Symptoms of Bleeding in the brain are 
• Frequent vomiting
• Blurred vision
• Extreme weakness in arms and legs
• Fatigue
• Convulsions

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DIAGNOSIS OF HEMOPHILIA

• The most common method for diagnosing Hemophilia
  is a blood test.
• The sample of blood taken from your vein
  indicates the factors responsible for Hemophilia.
• The blood test measures the amount of plasma
  present in your blood the low level of plasma in
  the blood indicates the severity of this bleeding
  disorder.

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TREATMENTS FOR HEMOPHILIA

• The treatment of this disease depends upon the
  type of Hemophilia a patient has. The treatment
  of each type of Hemophilia varies according to
  its type. 
• The treatment of Hemophilia A focuses on the
  hormone called, Desmopressin. This hormone is
  given as an injection in the patients vein. The
  Desmopressin hormone restores the factors
  important for clotting of blood.

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CONTINUE TREATMENT FOR HEMOPHILIA

• Hemophilia B is treated by infusing donors blood
  into the patients body, which lacks clotting
  factors. The clotting factors present the donors
  blood promotes the process of clotting of blood.
• Hemophilia C occurs due to the lack of plasma
  count in the body. Therefore, plasma infusion is
  done into the blood to combat the excessive
  bleeding.

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