Agenda:

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X PMT meeting June 6, 2012

• Agenda
• Update master tracers
• Update validation vs pathology
• Hippocampal 3D Object for AR Visualization
• Papers
• Next congress presentations meetings

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Benchmark Images
ADNI scans 2 x 5 Scheltenss atrophy score x 2
sides x 2 magnet strengths (1.5-3T) Total per
rater 40 hippos
The 5 Master Tracers completed segmentation of
R and L hippos of the 10 subjects received
feedback in cases of little compliance to the
Harmonized Protocol corrected segmentations
accordingly
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Benchmark Images
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Validation vs Pathology
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Validation versus pathology
1 tracer? (which one? A master? A naive qualified
on harmo prot?? O 3? (meglio 1)
?
Mayo Clinic AD CTRL dataset with
pathologically confirmed diagnosis (Braaks
stages), but not postmortem hippocampal
measurement
Mony DeLeon 15 AD 5 CTRL at 1.5T postmortem MRI
and quantitative histology (possible additional
AD cases)
Liana Apostolova (23 hippos at 7T) CA1 neuronal
counts, tau and Abeta immunoreactivity measures
? how many
?
Segmentation based on Harmonized Protocol Tot
ante mortem Tot 43 postmortem MRIs TOT images
?
Analysis based on the information available for
each dataset
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Validation versus pathology
Originally designated sample (Bobinski et al.,
2000) 11 AD 4 CTRL postmortem MRI and
quantitative histology de Leon 15 AD 5
CTRL postmortem MRI and quantitative histology
possible additional AD cases Jack AD CTRL
dataset with pathologically confirmed diagnosis
(controls and AD), but not post-mortem
hippocampal measurement. Liana? 23 (one side
only) 7T 60-hour postmortem scans (in progress
CA1 neuronal counts, tau and Abeta
immunoreactivity measures)
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Hippocampal 3D Object for AR Visualization
Segmentation Procedures
Manual Tracing (Simon)
Tool N 1 (FSL-FIRST)
Tool N 2 (FreeSurfer)


CTR SUBJ
MODELs to be Compared through SPHARM
vs.

Affected SUBJ
CTR Aff Subj




MODELs in AR

Common in all
Manual
Tool1
Alg1 Alg2
Alg3
Alg n
Tool2
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TOOL 1 Vs Manual Tracers
TOOL 2 Vs Manual Tracers
TOOL 3 Vs Manual Tracers
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Papers describing the project
Survey of protocols (preliminary phase
published, JAD 2011) Operationalization
(preliminary phase I revision, Alzheimers
Dementia, MS n. ADJ-D-12-00094) Axes check short
report (Brescia Team, in progress) Delphi
consensus (Brescia Team, in progress) Master
tracers practice and reliability (Brescia Team,
in progress) Development of certification
platform (Duchesne and coll) Validation data and
Protocol definition (Brescia Team) Validation vs
pathology (TBD)
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VALIDATION VS CURRENT PROTOCOLS ASSESSMENT OF
SOURCES OF VARIANCE TRAINING SET DEVELOPMENT
VALIDATION VS PATHOLOGY
GOLD STANDARD
20 naïve tracers
5 master tracers
1 tracer
Local Protocol ADNI scans 2 x 5 Scheltenss
atrophy scores x 2 sides x 2 magnet strengths
(1.5-3T)
Training ADNI scans 10 at 1.5T x 2 sides x 7 SUs
x 2 tracing rounds Total per rater 40 hippos
QUALIFICATION
QUALIFICATION
Harmonized Protocol ADNI scans 2 x 5 Scheltenss
atrophy score x 2 sides x 2 magnet strengths
(1.5-3T) Total per rater 40 hippos
Harmonized Protocol ADNI scans 2 x 5 Scheltenss
atrophy score x 2 sides x 2 magnet strength
(1.5-3T) Total per rater 40 hippos
Harmonized Protocol Pathological datasets Mayo
Clinic and NYU Total about 40 hippos
Assessment of variance due to rater and center
REFERENCE PROBABILISTIC MASKS with 95 C.I.
Best 5 naïve tracers
Assessment of agreement with volume on pathology
or ex vivo MRI and correlation with neuronal
density
Harmonized Protocol ADNI scans 2 sides x 5
Scheltenss atrophy scores x 3 time points
(bl-1y-2y) x 3 scanners ( retracing _at_ bl) x 2
magnet strengths (1.5-3T) Total per rater 240
hippos
Assessment of variance due to side,
trace-retrace, atrophy, time, scanner, rater
TRAINING SET
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Next congress presentations
- AIC 2012, Vancouver Abstract n. 26292, poster
presentation Definition of Harmonized Protocol
for Hippocampal Segmentation Session Date and
Time Saturday, July 14, 2012 - AAIC 2012,
Vancouver Abstract n. 26291, oral
presentation Definition of Harmonized Protocol
for Hippocampal Segmentation Session Title
Neuroimaging 4 MCI imaging markers of AD
pathology Presentation Number O2-11-02 Session
Start Day Time Jul 16 2012 330PM
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VI Hippocampal Protocol Harmonization Meeting
AAIC July 2012 Location Fairmont
Waterfront Vancouver, Princess Louisa Room
Date Time Wednesday, July 18, 2012 at 100
PM - 230 PM AGENDA Benchmark Images
Qualification Platform Improvement of the
Harmonized Protocol (based on the benchmark
tracing phase) Validation Phase 2
Advancing Paper Publication
Publication Policy
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GANTT