B Cell Maturation, Activation

1
B Cell Maturation, Activation Differentiation

• Hugh B. Fackrell
• Jan 4 ,1998

2
B Cell Maturation, Activation Differentiation

• Assigned Reading
• Content Outline
• Performance Ojectives
• Key terms
• Key Concepts
• Short Answer Questions

3
Assigned Reading

• Chapter 8 pp 195-222
• Janis Kubys Immunology 3rd Ed

4
Content Outline

• B Cell Maturation
• B Cell Activation Proliferation
• In Vivo induction of Humoral Response
• B Cell Differentation
• Regulation of B Cell Development

5
B Cell Maturation

• Bone marrow
• Ig Gene rearrangements
• Pre B cell receptor
• Selection of Immature Self Reactive B Cells
• negative selection
• rescue editing of light chain genes

6
B Cell Activation Proliferation

• T dependent vs T independent antigens
• Origins of activating signals
• Transduction of Activating signals
• B cell coreceptor complex
• T helper cells
• formation of T-B conjugate
• mediation by CD40
• induction of progression signals
• Negative selection

7
In Vivo Induction of Humoral Response
8
B Cell Differentation

• Affinity maturation
• somatic hypermutation
• antigen selection
• Class switching
• Plasma cells
• Memory cells

9
Regulation of B Cell Development
10
Performance Objectives
11
Key Terms

• affinity maturation, apotosis, avidity, capping,
  carrier effect, cell mediated immunity,Cytotoxic
  T cells, Helper T cells, TH1 cells, TH2 cells,
  humoral immunity, immunologic memory, perforin,
  plasma cells, primary antibody, programmed cell
  death, secondary antibody, thymus dependent
  antigens, thymus independent antigens

12
Key Concepts

• Describe the sequential development of the
  humoral immune response.
• Draw a contemporary model for T cell B cell
  macrophage interaction
• Describe antigen processing and presentation by B
  cells

13

• Outline the sequence of helper (T/(TH) cell
  involvment in antibody production
• Describe the interplay between TH1 and Th2 cells
  in the development of immune responses

14
Short Answer Questions
15
DONE!!!