Diapositiva 1

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SEMINARIO Antibiotic discovery at NAICONS

•  
• DR. STEFANO DONADIO
• Fundador y Presidente
• KtedoGen, Italia.
• http//www.ktedogen.com/stefano.html

Miercoles 20 de Octubre 1200pm Sala de
Seminarios 4º PISO, Edificio B
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Antibiotic discovery at NAICONS KtedoGen
NAICONS, Via Fantoli 16/15, 20138 Milano, Italy

•  
• There is an urgent need for new antibiotics
  effective against the increasing number of
  multidrug resistant pathogens. Natural products
  have represented and still represent an important
  source of chemical diversity. Our core technology
  is represented by a microbial product platform
  acquired from the former Biosearch Italia/Vicuron
  and we are thus undertaking different approaches
  to discover previously unreported chemical
  classes or significantly improved variants of
  existing classes. One approach is represented by
  data mining from a database of previously
  generated HTS data the other approach consists
  in directly screening new actinomycete taxa. For
  the data mining approach, we have looked at a
  program aimed at identifying inhbitors of cell
  wall biosynthesis. From it, we have identified
  several novel lantibiotics from diverse
  actinomycete genera, revised the structure of a
  previously reported molecule and compared their
  bioactivities to those of NAI-107, produced by a
  Microbispora strain, the most advanced compound
  in this series. NAI-107 shows excellent activity
  against all isolates of Staphylococcus aureus,
  Streptococcus pneumoniae and enterococci,
  irrespective of their reisistance phenotype. This
  molecule is also efficacious in several models of
  experimental infections. Other lantibiotics
  structurally related to NAI-107 have been
  characterized and their properties will be
  presented. Concerning the second approach, in the
  course of an isolation program aimed at
  identifying actinomycetes belonging to new taxa,
  we isolated hundreds of different representatives
  of a new taxon within the suborder
  Thermomonosporaceae, initially denominated
  "alpha" and independently named Actinoallomurus.
  We present a phylogenetic analysis of some
  strains from our collection and the preliminary
  results from a screening program, with the first
  metabolites identified from the genus
  Actinoallomurus.