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Pregnancy and Medical Imaging with or without Contrast

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Title: Pregnancy and Medical Imaging with or without Contrast


1
Pregnancy and Medical Imaging with or without
Contrast
2
Informed consent and understanding
  • The pregnant patient has a right to know the
    magnitude and type of potential radiation effects
    on a fetus that might result from in-utero
    exposure.

3
Evaluation of potentially pregnant patients
  • In females of child-bearing age, an attempt
    should be made to determine who is, or could be,
    pregnant, prior to radiation exposure.

4
Notices
  • A missed period in a regularly menstruating woman
    should be considered due to pregnancy, until
    proven otherwise.

5
MRI SCANS
  • MR Imaging is known to cause slight heating of
    the body of the patient being scanned.
  • There is at present no objective data to suggest
    that MR Imaging has any other adverse effects on
    the patient being scanned or on an unborn fetus.
  • It is not possible to determine the true risk of
    MR Imaging on an unborn fetus.
  • MR Imaging should be avoided unless a delay until
    after delivery would be dangerous to the fetus or
    mother.
  • If the only other means of diagnosis is with
    ionizing radiation, MR Imaging would be the
    preferred diagnostic study.
  • MR Imaging can if necessary, be performed at any
    stage in pregnancy.

6
  • Pregnant patients may undergo MRI scans at any
    stage of pregnancy, if the ordering physician
    determines the risk-benefit ratio for the patient
    warrants that the study be performed.
  • The justification for the exam must be documented
    in the patients hospital chart by the ordering
    clinician for inpatients or emergency room
    patients prior to the exam being performed.
  • For outpatients written documentation must be
    faxed to the department by the ordering clinician
    prior to the procedure being scheduled.
  • Gadolinium contrast will not be used during
    pregnancy without prior approval by a radiologist

7
Fetal radiation risk
  • There are radiation-related risks throughout
    pregnancy that are related to the stage of
    pregnancy and absorbed dose.
  • Radiation risks are most significant during
    organogenesis in the early fetal period, somewhat
    less in the 2nd trimester, and least in the 3rd
    trimester.

8
Radiation-induced malformations
  • Malformations have a threshold of 10-20 rad or
    higher and are typically associated with central
    nervous system problems.

9
Central nervous system effects
  • During 8-25 weeks post-conception the CNS is
    particularly sensitive to radiation.
  • Fetal doses in excess of 10 rad can result in
    some reduction of IQ (intelligence quotient).
  • Fetal doses in the range of 100 rad can result in
    severe mental retardation and microcephaly,
    particularly during 8-15 weeks and to a lesser
    extent at 16-25 weeks.
  • The accepted maximum cumulative fetal dose during
    pregnancy is 5 rad.

10
Breast Feeding and Contrast
  • An infant absorbs approximately 0.01 of the
    maternal intravenous dose of iodinated contrast
    from breast milk, over the first 24 hours
    (equivalent to less than 1 of the recommended
    dose for an infant undergoing a contrasted
    imaging study). The ACR recommends that it is
    safe to breast feed immediately after an
    iodinated study or she may wait 24 hours, if she
    continues to be concerned about potential risk.
  • An infant absorbs approximately 0.0004 of the
    maternal intravenous dose of gadolinium contrast
    from breast milk, over the first 24 hours
    (equivalent to less than 0.04 of the recommended
    dose for an infant undergoing a contrasted
    imaging study). The ACR recommends that it is
    safe to either breast feed immediately after a
    gadolinium contrast study or she may wait 24
    hours, if she continues to be concerned about
    potential risk.

11
Use of contrast (iodinated or gadolinium) during
pregnancy is recommended only if
  • The referring physician feels that the
    information gained by imaging with a contrasted
    study cannot be obtained by an alternative
    method.
  • The results will not affect the patient/fetus
    during the pregnancy.
  • Waiting after the pregnancy to obtain this
    information is not prudent for the
    patients/fetus care.
  • Documentation is made on the patients chart by
    the referring physician who has approved informed
    consent.
  • ACR Manual on Contrast Media (Version 5.0)

12
Common Radiographic Studies
13
Examination type Estimated fetal dose per examination (rad) Number of examinations required for a cumulative 5-rad dose
Plain Films
Skull 0.004 1,250
Dental 0.0001 50,000
Cervical Spine 0.002 2,500
Upper or Lower Extremity 0.001 5,000
Chest (two views) 0.00007 71,429
Mammogram 0.020 250
Abdominal (multiple views) 0.245 20
Thoracic Spine 0.009 555
Lumbosacral spine 0.359 13
Intravenous pyelogram 1.398 3
Pelvis 0.040 125
Hip (single view) 0.213 23
14
Examination type Estimated fetal dose per examination (rad) Number of examinations required for a cumulative 5-rad dose
CT scans 9slice thickness 10 MM) Non-helical
Head (10 Slices) lt0.050 gt100
Chest (10 slices) lt0.100 gt50
Abdomen (10slices) 2.600 1
Lumbar Spine (5 slices) 3.500 1
Pelvimetry (1 slice with scout film) 0.250 20
15
Examination type Estimated fetal dose per examination (rad) Number of examinations required for a cumulative 5-rad dose
Fluoroscopic studies
Upper GI Series 0.056 89
Barium Swallow 0.006 833
Barium Enema 3.986 1
Nuclear medicine studies
Most studies using technetium (99mTc) lt0.500 gt10
Hepatobiliary technetium HIDA scan 0.150 33
Ventilation-perfusion scan (total) 0.215 0.215 23
Perfusion portion Technetium .0175 28
Ventilation portion xenon (133 Xe) 0.040 125
Iodine ( I 131 ), at fetal thyroid tissue 590.000 Iodine (I 131) is contraindicated during pregnancy
16
Examination type Estimated fetal dose per examination (rad) Number of examinations required for a cumulative 5-rad dose
Environmental sources (for comparison)
Environmental background radiation (cumulative dose over nine months) 0.100 N/A
CT computed tomographic GIgastrointestinal
HIDAhepatobiliary iminodiacetic acid N/A not
applicable --Where the reference provides a
range of estimated doses, the highest value of
the range listed here. --Authors calculation
from data provided in reference values rounded
to lowest whole number.
17
Chest for Pulmonary Embolism
CT Helical Scan Estimated fetal dose per examination (rad) Estimated fetal dose per examination (rad) Estimated fetal dose per examination (rad)
1st Trimester 2nd Trimester 3rd Trimester
2.5 mm slice .00033 .00202 .00079-.00767 .000513-.001308
18
Helical CT Scans
Single Slice (5 mm thick) Multi-Slice (4) Detector (5 mm thick)
Abdomen 1.25 3.5 rad 1.25 3.5 rad
Pelvis 1.25 3.5 rad 1.25 3.5 rad
19
Nuclear medicine and pregnant patients
  • Most diagnostic procedures are done with
    short-lived radionuclides (such as
    technetium-99m) that do not cause large fetal
    doses
  • Often, fetal dose can be reduced through maternal
    hydration and encouraging voiding of urine
  • Some radionuclides do cross the placenta and can
    pose fetal risks (such as iodine-131)

20
Nuclear medicine and pregnant patient (contd)
  • The fetal thyroid accumulates iodine after about
    10 weeks gestational age
  • High fetal thyroid doses from radioiodine can
    result in permanent hypothyroidism
  • If pregnancy is discovered within 12 hours of
    radio-iodine administration, prompt oral
    administration of stable potassium iodine (60-130
    mg) to the mother can reduce fetal thyroid dose.
    This may need to be repeated several times

21
Approximate whole body fetal dose (rad) from
common nuclear medicine procedures
Procedure Activity (MBq) Early pregnancy 9 months
Tc-99m Bone scan Lung scan Liver colloid scan Thyroid scan Renal DTPA Red blood cell 750 240 300 400 300 930 0.47 0.09 0.06 0.44 0.9 0.6 0.18 0.09 0.11 0.37 0.35 0.25
I123 thyroid uptake 30 0.06 0.03
I131 thyroid uptake 0.55 0.004 0.015
22
Nuclear medicine and breast feeding
  • A number of radionuclides are excreted in breast
    milk. It is recommended that breast feeding is
    suspended as follows
  • Completely after I131 therapy
  • 3 weeks after I131, I125, Ga67, Na22, and Tl201
  • 12 h after I131 hippurate and all 99mTc compounds
    except as below
  • 4 h after 99mTc red cells, DTPA, and phosphonates

23
Conversions for Absorbed Dose
  • 0.001 rad 1 mrad 0.01 mGy
  • 0.01 rad 10 mrad 0.1 mGy
  • 0.1 rad 100 mrad 1 mGy 0.001 Gy
  • 1 rad 1000 mrad 10 mGy 0.01 Gy
  • 10 rad 100 mGy 0.1 Gy
  • 100 rad 1000 mGy 1 Gy (Gray)
  • 1000 rad 10 Gy

24
Termination of pregnancy
  • High fetal doses (100-1000 mGy, 10-100 rad)
    during late pregnancy are not likely to result in
    malformations or birth defects since all the
    organs have been formed
  • At fetal doses in excess of 500 mGy (50 rad),
    there can be significant fetal damage, the
    magnitude and type of which is a function of dose
    and stage of pregnancy
  • At fetal doses between 100 and 500 mGy (10 and 50
    rad), decisions should be based upon individual
    circumstances

25
Reference List
  • ICRP Publication 84, Task Group R. Brent, F.
    Mettler, L. Wagner, M. Berry, S. He, T. Kusama
  • Safety of Radiographic Imaging during pregnancy.
    Kevin S. Toppenberg, M.D., Ashley Hill, M.D. and
    David Miller M.S. Florida Hospital Medical
    Center. Orlando, Florida.
  • Policy for Handling Pregnant Patients. Georges
    Y. El-Khoury, M.D. and Mark Madsen, Ph.D., The
    University of Iowa Hospitals and Clinics,
    Department of Radiology.
  • Pulmonary Embolism in Pregnant Patients Fetal
    Radiation Dose with Helical CT, Helen T.
    Winer-Muram, M.D. et al, Indiana Univ. School of
    Medicine, Dept. of Radiology.

26
Web sites for additional information on radiation
sources and effects
  • European Commission (radiological protection
    pages) europa.eu.int/comm/environment/radprot
  • International Atomic Energy Agency
    www.iaea.org
  • International Commission on Radiological
    Protection
    www.icrp.org
  • United Nations Scientific Committee on the
    Effects of Atomic Radiation
    www.unscear.org
  • World Health Organization www.who.int
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