Title: Biliary and Pancreatic Anatomy
1Biliary and Pancreatic Anatomy
Liver
Gallbladder
Common bile duct
Pancreas
Pancreatic duct
Duodenum
2Pancreatic Anatomy
Insulin and glucagon
Blood
Islet cell secreting hormones
Cells secreting pancretic juice
Duodenum
Pancreas
Pancretic duct
Common bile duct
3Pancreatic Secretions
Cell Type Component Function
- Acinar Enzymes
Digestion - Ductal HCO3 and Water Protection
Digestion
4PANCREATIC ACINAR CELL
ATP
Secretin
Adenyl cyclase
cAMP
?
Enzymes
?
Ca2
Ach
Ca2 stores
IP3
CCK
Primary Stimulus
The Hormones also Modulate Enzyme Expression
5Pancreatic Duct Cell
6Regulators of Pancreatic Secretion
Cell Type PrimaryActivator Potentiator
- Acinar CCK / Ach Secretin
- Ductal Secretin CCK / Ach
(Ca2 )
(cAMP )
Cephalic and Gastric Neural Ach Intestinal
Hormonal
7Liver
Hepatic Ducts
Left
Right
Pancreatic Duct
Common Bile Duct
Cystic Duct
Ampulla of Vater
Gallbladder
Sphincter of Oddi
Duodenal Lumen
8- Excretory Component - Bilirubin, Drug
Metabolites. - Secretory Component
- Bile Produced and Filtered by Hepatocytes
- Primary Bile Acids Cholic
Acid, Chenodeoxycholic Acid - Secondary Bile Acids - Formed by Bacteria
in the Intestine - Deoxycholic Acid, Lithocholic Acid
9Bile Acids
Secondary bile acids
Primary bile acids
20
80
Fraction of Total
Deoxycholic acid
Cholic acid
Cholesterol
Cholesterol 7-hydroxylase
Amphipathic Carboxylic Acids
Lithocholic acid
Chenodeoxycholic acid
Liver
Intestine
10Bile Acids are Amphipathic
Have both Hydrophilic and Hydrophobic domains
Formation of Micelles
Co-Lipase
C
11Hepatic cell plate
Bile canaliculus
Central vein
Kupffer cell
Venous sinusoid
Terminal bile duct
Portal venule
12To Systemic Circulation
Rates ml/min
Aorta
LIVER
HEPATIC
Celiac (700)
(200)
STOMACH
SPLEEN
Superior Mesenteric (700)
(1800) mls/min
Portal Vein
PANCREAS
SMALL INTESTINE
Inferior Mesenteric (400)
COLON
13EnterohepaticCirculation
14SECRETIONS of the INTESTINES
Information pertaining to the next 3 slides is
found in the Lecture Notes for the last Lecture
15Cell Loss
Blood vessels Lymph vessels Nerves Smooth
muscle Connective tissue lymphocytes Plasma
cells Eosinophiles
Absorp- tive cells
Villous epithelium
Goblet cells
Crypt lumen
Undifferentiated
Crypt epithelium
Goblet
Mitoses
Endocrine cells
Endocrine cells
Muscularis mucosa
16Secretions of the Small Intestine (2000 ml/day)
-
- Crypts of Lieberkuhn Small and Large Intestine
- Contain Primarily Epithelial Cells, Mucus Goblet
Cells, and Endocrine Cells. - Water Secretion - VIP Activates Water Secretion
by Elevating cAMP and Cl- conductance. - Cell Growth and Differentiation Cell Turnover at
the Tip of a Villus is High (3-6 day Cycle).
17Key Players cAMP Activated Cl- Channel Na / K
/ Cl- Co-transport Na-K ATPase
VIP neurotransmitter Histamine also can
activate