SHIGELLOSIS

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• SHIGELLOSIS

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• Etiology
• non-motile, non-spore-forming,
• Gram negative bacillus
• four species
• Shigella dysenteriae
• S. flexneri
• S. boydii
• S. sonnei

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• Epidemiology
• Source of infection
• patients and carriers
• Route of transmission
• fecal-oral
• Susceptibility
• universal
• Epidemiological characteristics

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• Pathogenesis
• Shigella living in colonic epithelial cells
• release endotoxin multiply
• superficial mucosal ulcerations

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• Clinical Manifestations
• acute typical form
• acute onset, high fever, abdominal pain,
  diarrhea, tenesmus, stool with blood,
• mucus, non-mixed with fecal material, little
  amount each time
• mild form
• toxic form
• chronic form

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• Complications
• Shigella septicemia
• arthritis
• hemolytic uremic syndrome

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• Diagnosis
• Epidemiological data
• Clinical manifestations
• Laboratory findings
• pathogenic bacteria culture
• yield Shigella

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• Differential diagnosis
• amebic dysentery
• bacterial food poisonings
• campylobacter enteritis
• Escherichia enteritis
• acute schistosomiasis
• ulcerative colitis
• rectal carcinoma
• Japanese encephalitis for toxic form

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• Treatment
• Supportive treatment
• Symptomatic treatment
• Etiological treatment
• quinolones ofloxacin, ciprofloxacin
• ampicillin and gentamicin for toxic form cases

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• Prevention
• Control the source of infection
• Interrupt the route of transmission
• Protect susceptible persons

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• Thank you for listening