PP27 Endocrine Patterns During Pregnancy

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PP27Endocrine Patterns During Pregnancy
Parturition
Chapter 14 pg 314-325 ANS 3319Dr. Michael J.
FieldsUniversity of Florida
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Progesterone Steroid of Pregnancy

• Progesterone pro-gestation.
• Maintains uterus in a state for pregnancy.
• Organizes ovulations - regulates pituitary.
• 1st P4 acts on Endometrium.
• P4 is regulatory.
• P4 acts to code secretion of proteins.
• 2nd P4 acts on Myometrium to inhibit contractions.

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Source of ProgesteroneCow

• Cow - 282 days of gestation.
• CL required for 200 days.
• After day 200, pregnancy will continue without
  it, although with some problems
• Dystocia, retained placenta, death loss.
• Placenta produces P4 after day 200.

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Source of ProgesteroneEwe

• Sheep - 147 days of gestation.
• CL (n 3 to 5) required for first 50 days.
• After day 50, placenta takes over.

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Source of ProgesteronePig

• Pig - 115 days of gestation.
• CL required throughout pregnancy.

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Source of ProgesteroneMare

• Horse - 340 days of gestation.
• CL Accessory CL (n 3 to 5) form day 55.
• Placental eCG (endometrial cups) signal for
  Luteinization of follicles starts day 38.
• Placenta takes over about day 180.

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Source of Progesterone

• Human
• CL required through 5th week.
• Placenta takes over thereafter.
• Highest blood P4 of any species due to Steroid
  (Corticosteroid) Binding Globulin.

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