Disease Biophysics Group Will Adams

1
Sarcolemmal Displacement

• Will Adams

2
Cardiac Myopathies
Dilated Cardiomyopathy
Physiological
medlib.med.utah.edu
Hypertrophy (concentric)
medic.med.uth.tmc.edu
3
Individual Myocyte Geometry
Physiological
Concentric Hypertrophy
Dilated Cardiac Myopathy (eccentric hypertrophy)
4
Displacement

• Why displacement?
• Mechanical energy dissipated from internal
  viscosity will depend on displacement and
  velocity
• Perhaps the pathological morphology of the heart
  is maladaptive not only on a macroscale (ejection
  fraction) but on a microscale (intracellular drag)

5
Longitudinal Displacement
Stress
Displacement
6
Longitudinal Displacement
7
Transverse Displacement
8
Results
Critical Ejection Fraction
Systole
Diastole
Hypertension
9
Directions

• Maintain cytosolic volume conservation
• Intregrate a t-tubule network into ABAQUS

http//mednote.co.kr/
10
Acknowledgements

• Adrian Podpirka