An%20Introduction%20to%20Derwent%20World%20Drug%20Index

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• An Introduction to Derwent World Drug Index
• Richard Lambert
• Pharmaceutical Product Manager

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World Drug Index - Background

• World Drug Index launched in 1994
• Originated from Standard Drug File (SDF)
• Coverage back to 1964
• Contains only named compounds, including Trial
  Preparation Codes
• Released on a quarterly cumulative basis

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World Drug Index - What is it?

• Integrated drug database containing
• marketed drugs
• drugs in development
• new chemical entities (NCEs) from scientific
  literature or reported at conferences
• Text and structure searchable
• 20 searchable fields with controlled keywords
• Standard conventions for selection and structure
  input

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World Drug Index - Coverage/Selection Guidelines

• Source Materials
• Literature articles from over 1,200 journals
• Conference proceedings (approx. 20 per year)
• Pharmacopoeias and Approved Name Lists
• Selection Criteria
• All named compounds from the Derwent Drug File
• All named compounds from Conference Fast-Track
• Named compounds from pharmacopoeias and approved
  name lists (e.g. USAN and INN)

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World Drug Index - Statistics

• Over 64,000 drug records
• 4000 new records per annum
• 16,000 updates to existing records per annum
• Over 203,000 synonyms
• 12,000 Approved Names
• 34,000 Trial Preparation Codes
• 144,000 Trade Names/Trivial Names
• 13,000 Combination Names
• Over 20,000 source references (added since 1994)

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World Drug Index - Data fields

• Derwent Drug Name
• Structure
• Derwent Registry Name
• Pharmacological Activity / Mechanism of Action
• Reference
• Chemical Substructure keywords
• Synonyms
• Biomedical Data

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World Drug Index - Features/Uses

• Structure/sub-structure activity relationships
• Archive reference file for marketed and
  development drugs
• Information on drug manufacturers and countries
  of origin/sale
• Trade name and synonym searching

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World Drug Index - Daylights Implementation

• Full Version
• Lite Version
• Includes
• Structural data
• Synonyms
• Activity
• Excludes
• Mechanism of Action
• Biomedical Information

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World Drug Index - HTML Version

• Simple intuitive interface
• Text fields
• Names
• CAS numbers
• Smiles
• Structure searchable using GRINS
• Exact
• Substructure
• Superstructure

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