Vitamin K

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Vitamin K

• I am not responsible for errors

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History

• What happens when a fat free diet is given to
  chickens?

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• Chickens given a fat free diet die a horrible
  hemorrhagic condition.

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• T or F
• There is an RDA value for Vitamin K

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• False there is no RDA value
• There is an AI value for this drug
• What is the AI for this vitamin

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• AI
• Women 90 µg
• Men 120 µg

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• What are the two types of vitamin K?

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• Vit K1
• Vit K2

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• The commercial form of vitamin K is?

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• Phytonadione
• Vitamin K1
• Phylloquinone

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• What is the administered form IV of Vit K?

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• Menadione

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• T or F
• The active form is produced in the intestine by
  intestinal bacteria

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• False
• The conversion to the K2(20) product occurs in
  the liver.

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• What is the role of ?-carboxyglutamic acid in
  clot formation?

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• Part of the clotting process requires
  complexation of Ca by ?-carboxyglutamate.

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• Why does blood not coagulate while your giving
  blood?

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• Blood does not coagulate in the bag because
  citric acid is placed into the bag to chelate the
  Ca before it can be complexed by the
  prothrombin.

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• How does Warfarin work?

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• Warfarin works by inhibiting K-reductase, and
  thioredoxin two reductive enzymes.

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• What enzymes are inhibited by coumadin?

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• Thioredoxin
• K-Reductase

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• What is a possible complication as a result of a
  vitamin K deficiency?

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• Hemorrhage

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• T or F

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• T or F
• Oregon and most states require that each newborn
  receive an injection of Menadione.

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• False (If you just said True, You just killed a
  baby.
• Oregon and most states require that each newborn
  receive an injection of phytonadione

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• Why should Menadione not be given to children?

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• Menadione injection can cause hemolytic anemia in
  the newborn.

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• Common Causes of Deficiency?

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• Obstructive Jaundice
• Loss of Intestinal Flora
• Hemorrhagic Disease of Newborn

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• K1 Series

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• Inactive dietary precursor to K2 (ex.
  Phytonadione, phylloquinone.)

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• What does K2 Series

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• K2 series produced by bacteria in intestinal
  lining and putrefied food