Nutritional Strategies for AntiAging

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Nutritional Strategies for Anti-Aging

• Susan Vannucci, D.O.
• Umpqua Valley Womens Care, P.C.

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Functional Medicine Clinical Approach

• Functional medicine is integrative, science-based
  healthcare which treats illness and promotes
  wellness by focusing assessment of the
  biochemically unique aspects of each patient, and
  then employs individually tailored interventions
  to restore physiological, psychological and/or
  structural balance.

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8 Modifiable Risk Factors of Unhealthy Aging

• Chronic Inflammation
• Poor Nutrition and Digestion
• Dysglycemia
• Impaired Mitochondrial Function
• Impaired Detoxification Capacity
• Imbalanced Methylation Reactions
• Poor Immune Function
• Hormonal Imbalances

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HOW DID THIS HAPPEN?
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Does Quality Matter?
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Diseases Unequivocally Associated With Poor Diet

• Obesity
• Heart Disease
• Hypertension
• Diabetes
• Breast, Colon, Prostate Cancer
• Dental Disease
• Birth Defects
• Cataracts

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Parkinsons
Fatigue
Pain
INFLAMATION
Alzheimers
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Management of Inflammation
Fish Oils EPA/DHA 1 or 2 TID
Ginger, Turmeric, Boswelia Niacinamide NAC
Ultra InflamX
Hops extract Humulus Synergists
2 scoops BID
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Cell Membrane
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Changing fatty acid intakeomega-6 omega-3
ratios
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Major Physiological Roles of EFAS

• Precursors for eicosanoid synthesis
• Local hormones
• Regulate inflammation
• Regulate smooth muscle contraction
• Structural components of all membranes
• Fluidity and permeability
• Optimal hormones and neurotransmitter receptor
  and function

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EFA Imbalances

• Arthritis
• Auto-immune diseases
• Eczema, Asthma
• Atherosclerosis
• Cardiovascular disease (Low DGLA, Low EPA/DHA,
  high AA)
• Depression (severity correlates with the AAEPA
  ratio)

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Benefits of Omega 3 Fatty Acids

• Makes it possible for substances in the blood to
  pass through the cell wall
• Decreases inflammation
• Lowers triglycerides, raises HDL
• Makes blood less sticky
• Dilates or constricts blood vessels in the
  stomach, intestines, uterus and bronchial tree
• Decreases blood pressure

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Benefits of Omega 3 Fatty Acids

• Decreases arrhythmias
• Enhance insulin action
• Needed for normal function of the brain, eyes,
  inner ear, adrenal glands and reproductive tract
• Important for mitochondrial function

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Omega 3-Fatty Acids Decrease Inflammation

• Alpha-linolenic - flax, hemp seed, canola,
  soybean, walnut, and dark green leaves
• Stearidonic acid black current seeds
• Eicosapentaenoic acid (EPA) and Docosahexaenoic
  acid (DHA) fish, nuts, lamb

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Omega 6 Fatty acids Produce Inflammation

• Linoleic safflower, sunflower, hemp, soybean,
  walnut, pumpkin, sesame and flax oil
• Gamma linolenic (GLA) borage, black current and
  evening primrose oil
• Dihumogamma-linolenic acid (DGLA) occurs in
  mothers milk
• Arachidonic acid occurs in meats and animal
  products

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Free radical theory of aging Denham Harman,
M.D., Ph.D. (1954)
Each 24 hours, approximately 1 trillion molecules
of oxygen pass through every cell of the
body. This results in 100,000 free radical hits
or wounds on the cellular DNA. Dr. Bruce N.
Ames, geneticist University of California at
Berkeley.
Aging occurs as cells are permanently damaged by
continual attacks from chemical particles known
as free radicals. (Oxidation)
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Oxygen and Free Radicals

• Whenever oxygen is used some of it is transformed
  into free radicals
• Free radicals react with and damage
• membranes
• enzymes
• Mitochondria
• DNA

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Plan fighting the Free radicals

• High- potency antioxidant Multi-vitamin and
  mineral (Vitamins A, C, E, Zinc, Selenium)
• Alpha-lipoic acid 100 to 300 mg
• Coenzyme Q10 100 to 200 mg
• Resveratrol 20 mg

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MITO(Energy)Nutrients
EXERCISE (600) CoQ10, NAC, Lipoic Acid, Mg, Cu,
C, E, B1, B2, Creatine, Glutathione, Carnitine,
Isoleucine (Mito Resuscitate) DeTox
Protocols Anti Oxidants EPA / DHA
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I dont think that I have the ENERGY to hold on
much longer.
Death of the organism occurs when there is a
complete loss of its energy producing
capacity. William R. Clark, Professor Emeritus
of Immunology at UCLA, A Means to an End The
Biological Basis of Aging and Death. Pg 23.
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Mitochondria
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Mitochondria Power House of the Cell

• The mitochondria consume 90 of the oxygen used
  by the body
• The body uses oxygen in the body for
• Energy production
• Detoxification
• Immune function
• Hormone production

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Alpa- Lipoic acid

• Improves your immune system
• Prevents cataracts
• Cofactor of mitochondrial enzymes needed for
  energy metabolism
• Helps insulin work more effectively
• Strengthens memory and prevents brain aging
• Stimulates the sprouting of new nerve fibers on
  cells

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Alpha- Lipoic acid

• Recycles Vitamin E, C and Coenzyme Q10
• Acts as a metal chelator for iron, copper and
  cadmium
• Stops the adhesions of macrophages to your artery
  wall (helps prevent heart disease)
• Stops the NF Kappa B activation which leads to
  heart disease
• Modulates gene expression

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Alpha Lipoic acid is used for treatment of

• Diabetes, diabetic neuropathy
• Heart disease, stroke, circulatory disorders
• Parkinsons disease, MS, Lou Gehrigs disease
• Cataracts, Macular degeneration
• Rheumatoid arthritis, Lupus, Scerloderma
• Psoriasis, eczema, burns, skin cancer
• Immunodepression, AIDS, Hepatitis C

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Coenzyme Q-10

• A fat soluble nutrient made in almost every
  tissue in your body, however, the amount you make
  declines with age.
• Function
• Anti-oxidant
• Coenzyme for energy metabolism in all your cells
• Lowers blood pressure
• Reduces platelet stickiness
• Enhances the regeneration of Vitamin E

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Coenzyme Q10 is effective in the treatment and
prevention of

• Heart disease, Congestive heart failure,
  arrythmia, Mitral valve disease, Dilated
  cardiomyopathy
• Alzheimers, Parkinsons disease
• Chronic fatigue, Fibromyalgia
• Asthma, COPD, Pulmonary fibrosis
• Peridontal disease
• Sun damaged skin

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What Causes a Deficiency of Coenyme Q10?

• Drugs
• Beta blockers, Clonidine, Hydralazine,
  Hydroclorthiazide
• Statins
• Glucophage, Glyburide,
• Phenothiazines, Desipramine, Haloperidol,
  Imipramine, Chlorpromazine, Trimipramine
• Doxepin
• Adriamycin

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What Causes a Deficiency of Coenyme Q10?

• Exercise
• Hyperthyroidism
• Malabsorption
• Insufficient dietary intake of taurine ( an amino
  acid found in brewers yeast, eggs, fish, meat,
  seafood

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Resveratrol

• A Bioflavonoid in wine, grapes, peanuts and
  mulberries
• Anti-oxidant, anti-inflammatory, decreases
  platelet stickiness, prevents LDL cholesterol
  oxidation, stops the proliferation of cells that
  narrow your arteries, helps prevent Alzheimers
  disease, opens arteries by increasing nitric
  oxide, helps with detoxification in the liver.

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Ginko Biloba

• Anti-oxidant
• Increases oxygen to the brain by increasing blood
  supply (dilates vessels)
• Decreases blood clotting
• Improves learning, memorization, mood
• Dosage 40 80 mg
• CAUTION do not take if you are on a blood
  thinner

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Ginko Biloba is effective for treating

• Memory loss, depression
• Peripheral vascular disease, Raynauds disease
• Macular degeneration, glaucoma, Diabetic
  retinopathy
• Impotence

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"70 million Americans deal with digestive
disorders . . Each month 44 percent of adults
take antacids or other medicines to treat
heartburn. http//www.gastro.org/public/brochur
e/yourdigest.htmlYear 2000 - 41.5 million doctor
and hospital visits for GI problems.http//www.cd
c.gov/nchs/fastats/digestiv.htm
GI Disorders 1. Leaky Gut 2. Hypo Acidity 3.
G.E.R.D. 4. (hiatal hernia) 5. Pancreas 6. Gall
Bladder 7. Constipation
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Digestion Recommendations
GI Disorders 1. Glutamine, Aloe Vera,
Licorice. 2. Betaine HCl (maximum tolerable dose
after meals) 3.Glutamine, Chinese Botanical 4.
Mechanical correction 5. Pancreatic Enzymes 6.
Inositol, Choline 7. Mag Citrate 4 /- before
sleep, Flora, Meta Fiber Hydrocolonics
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HCl
Protein Digestion
Secretin Altered Intestinal pH Poor digestion,
Dysbiosis, Leaky Gut Systemic
Inflammation
Enzyme Replacement Therapy of Exocrine Pancreatic
Insufficiency in Man, David V. Graham, M.D.
NEJM, 2961314-1317 (June 9), 1977.
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Betaine molecule with 3 methyl groups.
http//www.alliancepeche.net/galerie/data/media/8/
molecule.jpg
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Directions For Use of Betaine HCl gentianWhen
using Betaine HCL with Pepsin for the first few
times, please be sure to follow the directions
carefully. Always take Betaine HCL at the end of
the meal after your typical digestive processes
have started.1. At the very end of the meal,
take one tablet of Betaine HCl. Monitor how your
stomach feels after eating. Should any burning or
heaviness occur, or if burning has been present
previously (before taking the supplement) and is
now worsened with the use of the Betaine HCl, do
not continue using this supplement!!! This is an
indication that your stomach is overproducing
acid, or that your stomach lining may be damaged.
An alkalizing agent like baking soda or alka
seltzer can be used to relieve the burning.2.
If the first dose of Betaine HCL provided no
noticeable stomach discomfort, try taking two
tablets at the end of your next meal, again
monitor for burning and or heaviness after
eating. If taking two tablets produces some
discomfort, but one tablet does not, restrict
yourself to one tablet at the end of each meal.
If the two tablet dose produced no discomfort,
try three tablets at the end of your next
meal.3. If all goes well when taking three
tablets at the end of each meal, stay with that
dose. Most individuals will not require
increasing the dose to four tablets. Regular use
of supplemental hydrochloric acid (with gentian)
will in most cases "re-train" the stomach to
produce higher concentrations of acid on its own.
This process may take anywhere from several weeks
to several months, depending on the individual.
The most significant indication that acid
production is improving is that Betaine HCL
supplementation can no longer be comfortably
tolerated.
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Other Important Nutrients

• Siberian Ginseng
• Probiotics, digestive enzymes, betain HCL
• Bilberry
• L-carnitine, CLA, carnosine
• Brain nutrients
• Phosphatidyl choline
• Phosphatidyl serine
• Vinpocetine