Eugene P' Mayer - PowerPoint PPT Presentation

1 / 23
About This Presentation
Title:

Eugene P' Mayer

Description:

Foreignness. Size. Conformational determinants. Sequence determinants. Chemical Composition ... Some glycolipids and phosopholipids can be immunogenic for T ... – PowerPoint PPT presentation

Number of Views:37
Avg rating:3.0/5.0
Slides: 24
Provided by: Eugene55
Category:

less

Transcript and Presenter's Notes

Title: Eugene P' Mayer


1
Eugene P. Mayer
  • Office Bldg. 2, Rm. B19
  • Phone 733-3281
  • Email MAYER_at_MED.SC.EDU

2
Overview of the Immune System
3
Antigens
4
Definitions
  • Immunogen
  • Antigen (Ag)
  • Hapten
  • Epitope or Antigenic Determinant
  • Antibody (Ab)

5
Factors Influencing ImmunogenicityContribution
of the Immunogen
  • Foreignness
  • Size
  • Chemical Composition
  • Primary Structure
  • Secondary Structure
  • Tertiary Structure
  • Quarternary Structure

6
Factors Influencing ImmunogenicityContribution
of the Immunogen
  • Foreigness
  • Size
  • Chemical Composition
  • Physical Form
  • Particulate gt Soluble
  • Denatured gt Native

7
Factors Influencing ImmunogenicityContribution
of the Immunogen
  • Foreigness
  • Size
  • Chemical Composition
  • Physical Form
  • Degradability
  • Ag processing by Ag Presenting Cells (APC)

8
Factors Influencing ImmunogenicityContribution
of the Biological System
  • Genetics
  • Species
  • Individual
  • Responders vs Non-responders
  • Age

9
Factors Influencing ImmunogenicityMethod of
Administration
  • Dose
  • Route
  • Subcutaneous gt Intravenous gt Intragastric
  • Adjuvant
  • Substances that enhance an immune response to an
    Ag

10
Chemical Nature of Immunogens
  • Proteins
  • Polysaccharides
  • Nucleic Acids
  • Lipids
  • Some glycolipids and phosopholipids can be
    immunogenic for T cells and illicit a cell
    mediated immune response

11
Types of AntigensT-independent
  • Polysaccharides
  • Properties
  • Polymeric structure
  • Polyclonal B cell activation
  • Yes -Type 1 (TI-1)
  • No - Type 2 (TI-2)
  • Resistance to degradation
  • Examples
  • Pneumococcal polysaccharide, lipopolysaccharide
  • Flagella

12
Types of AntigensT-dependent
  • Proteins
  • Structure
  • Examples
  • Microbial proteins
  • Non-self or Altered-self proteins

13
Hapten-carrier conjugates
  • Definition
  • Structure
  • native determinants
  • haptenic determinants

14
Antigenic Determinants Recognized by B cells and
Ab
  • Composition
  • Proteins, polysaccharides, nucleic acids
  • Sequence (linear) determinants
  • Conformational determinants
  • Size
  • 4-8 residues

15
Antigenic Determinants Recognized by B cells and
Ab
  • Composition
  • Size
  • Number
  • Limited (immunodominant epitopes)
  • Located on the external surfaces of the Ag

16
Antigenic DeterminantsRecognized by T cells
  • Composition
  • Proteins (some lipids)
  • Sequence determinants
  • Processed
  • MHC presentation (lipid presentation by MHC-like
    CD1)
  • Size
  • 8 -15 residues
  • Number
  • Limited to those that can bind to MHC

17
Superantigens
  • Definition

Monoclonal/Oligoclonal T cell response 1104 -
1105
18
Superantigens
  • Definition
  • Examples
  • Staphylococcal enterotoxins
  • Staphylococcal toxic shock toxin
  • Staphylococcal exfoliating toxin
  • Streptococcal pyrogenic exotoxins

19
Determinants Recognized by the Innate Immune
System
  • Adaptive Immune System Discrete Determinants
  • Reacts with a specific pathogen
  • Innate Immune System Broad Molecular Patterns
  • Reacts with a variety of pathogens

20
Determinants Recognized by the Innate Immune
System
  • PAMPs Pathogen Associated Molecular Patterns
  • PRRs Pattern Recognition Receptors

21
(No Transcript)
22
(No Transcript)
23
(No Transcript)
Write a Comment
User Comments (0)
About PowerShow.com