Brief Summary:

1

• Brief Summary
• Pyridine Pyrrole
• Acid/base chemistry
• D/A properties ? H-bonding (non-specific)
• Nitrogeneous bases ? specific H-bonding
• Prebiotic formation
• Reactions of pyridine (N as a nucleophile)

2

• Sugars
• Fischer projections
• Haworth projections
• Chair conformations

3

• Reactions of sugars

4

• Example AZT ? protecting group chemistry
• NMR (practice on wed.)
• Spectra of sucralose
• Karplus curve
• 2D NMR
• COSY (1H correlation), NOESY (through space),
  HSQC (1H -13C)

5

• Sugars in the pre-biotic world
• Modern world
• Thiazolium ion
• Nuceosides (sugar base)
• Nature prebiotic world
• Oxonium ion base
• Nucleotides ( phosphate)
• Phosphorylation
• Modern world ATP
• Prebiotic world cyclo-triphosphate?

6

• Ribozymes
• Self-cleaving riboswitch
• Mechanism of cleavage
• Chemical synthesis of Oligos
• Solid phase synthesis
• Protecting groups
• P
• Cycles
• DNA/RNA analogues
• Structure-activity relationships
• Antisense technology
• Base ?
• Backbone ?
• Sugar ?

7

• Urey-Miller Expt
• Simulated prebiotic conditions