THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1947

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THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1947
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The Nobel Prize in Physics 1947

• "for his investigations of the physics of the
  upper atmosphere especially for the discovery of
  the so-called Appleton layer"

Sir Edward Victor Appleton (United Kingdom)
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The Nobel Prize in Chemistry 1947

• "for his investigations on plant products of
  biological importance, especially the alkaloids"

Sir Robert Robinson (United Kingdom)
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The Nobel Prize in Literature 1947

• "for his comprehensive and artistically
  significant writings, in which human problems and
  conditions have been presented with a fearless
  love of truth and keen psychological insight"

André Paul Guillaume Gide (France)
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The Nobel Peace Prize 1947
American Friends Service Committee (The Quakers)
Washington, DC, USA
Friends Service Council (The Quakers) London,
United Kingdom
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THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 1947
GERTY THERESA CORI, NÉE RADNITZ USA
(1896-1957) 3rd woman to win the Noble prize.
CARL FERDINAND CORI USA (1896-1984)

• "for their discovery of the course of the
  catalytic conversion of glycogen"

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CORI CYCLE
The Cori cycle is their explanation for the
movement of energy in the bodyfrom muscle, to
the liver, and back to muscle.
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Bernardo Alberto Houssay(Argentina)
(April 10, 1887 September 21,1971)

• "for his discovery of the part played by the
  hormone of the anterior pituitary lobe in the
  metabolism of sugar"

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• Carbohydrates produced from food or liver
• Used by muscles
• Production and consumption of carbohydrates-Consta
  nt blood sugar level
• The liver
• Hypoglycemia when liver is removed
• Hyperglycemia-the liver diminishes or ceases the
  production of sugar, and stores it.

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• The pancreas secretes insulin in adequate
  quantities so as to maintain a normal blood sugar
  level, and the blood sugar level regulates the
  amount of insulin secreted. Thus hyperglycemia
  increases the secretion of insulin and
  hypoglycemia diminishes or completely inhibits it.

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• He found that hypophysectomized dogs were
  hypersensitive to the toxic and hypoglycemic
  action of insulin
• These discoveries stimulated the study of
  harmonal feedback control mechanisms which are
  central to all aspects of modern endocrinology.

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Outline

• Carbohydrate metabolism and other metabolic
  processes are regulated by the balance maintained
  between the secretion of several endocrine
  glands.
• Diabetes and other metabolic diseases are a
  disturbance in this endocrine equilibrium.

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FIGURE SHOWING THE ANTERIOR PITUTARY LOBE
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• Due to the body's ability to hold no more than
  around 2,000 kcal of glycogen, marathon runners
  commonly experience a phenomenon referred to as
  "hitting the wall" around the 20 mile (32 km)
  point of a marathon. (Approximately 100 kcal are
  utilized per mile, depending on the size of the
  runner and the race course.) When experiencing
  glycogen debt, runners many times experience
  fatigue.

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References

• http//nobelprize.org/
• http//en.wikipedia.org/wiki/Main_Page