Mission and Objectives

1
Mission and Objectives
UC CEIN Interdisciplinary Research Groups (IRGs)

• The mission of the UC CEIN is to ensure that
  nanotechnology is introduced in a responsible and
  environmentally compatible manner to allow the US
  and international communities to leverage the
  benefits of nanotechnology for global, economic,
  and social benefit.
• The UC CEIN seeks to
• Develop a library of reference nanomaterials
  (NMs)
• Develop a predictive model of toxicology the
  environmental impacts of NMs
• Understand the impacts of NMs on organisms and
  ecological systems, and
• Develop guidelines and decision tools for the
  safe design and use of NMs.

100s/year
1000s/year
10,000s/day
100,000s/day
IRG Leader Barbara Herr Harthorn, UCSB
R. Werlin, J.H. Priester, R.E. Mielke, S.
Jackson, G.D. Stucky, G. Cherr, E. Orias, P.A.
Holden
IRG Leader Jeffrey Zink, UCLA
IRG Leader Patricia Holden, UCSB
IRG Leader Hunter Lenihan, UCSB
Challenges Screening the effects of new
nanomaterials (NM) requires the development of
models for the environmental distribution of NM
and their toxicity.

• Goals
• Similarity criteria for NM and data-driving
  QSPRs and
• QSARs models for NM physicochemical properties
• and toxic effects
• Environmental intermedia transport relations for
  NM
• and multimedia NM transport
• Decision tools for the safe use and design of NM

IRG4 research focuses on understanding the
mobility and bioavailability of NPs in different
environmental conditions. Our work with metal
oxide NPs has shown that they can be easily
stabilized under freshwater conditions, which is
a major pathway from the sources (e.g. wastewater
treatment plant discharge, stormwater, other
runoff) into other environmental compartments,
such as estuaries and oceans, where the particles
sediment rapidly. This has important implications
for aquatic organisms that are exposed to
particles either in the water column or sediments.
Solutions Develop and apply machine learning
techniques for NM classification and property
predictions Apply multimedia transport and fate
models to evaluate the dynamic mass distribution
of NM, and Apply decision tools incorporating
quantitative and qualitative information for
decision making
Acknowledgements
1 Department of Environmental Health Science,
UCLA School of Public Health, 16-035 CHS, BOX
951772, Los Angeles, CA 90095. 2 UC Center for
the Environmental Implications of Nanotechnology
(UC CEIN), University of California Los Angeles,
6522 CNSI, 570 Westwood Plaza, Los Angeles, CA
90095-7277. 3 California NanoSystems Institute,
University of California Los Angeles, 570
Westwood Plaza, Building 114, Los Angeles, CA
90095. 4 Division of NanoMedicine, Department of
Medicine, University of California, Los Angeles,
California 90095. 5 Department of Chemical and
Biomolecular Engineering, 5531 Boelter Hall,
University of California Los Angeles, Los
Angeles, California, USA 6 School of
Environmental Science and Management, University
of California, Santa Barbara 7 Department of
Ecology, Evolution Marine Biology University of
California Santa Barbara
IRG Leader Yoram Cohen, UCLA
IRG Leader Arturo Keller, UCSB
IRG Leader Kenneth Bradley, UCLA
The UC Center for Environmental Implications of
Nanotechnology (UC CEIN) at UC Los Angeles (UCLA)
is in partnership with UC Santa Barbara (UCSB),
UC Davis (UCD), UC Riverside (UCR), Columbia
University in New York, the Molecular Foundry at
Lawrence Berkeley National Laboratory (LBNL), the
Lawrence Livermore National Laboratory (LLNL),
Nanyang Technological University in Singapore
(NTU), University of New Mexico (UNM), Sandia
National Laboratory (SNL), University of Texas in
El Paso (UTEP), University of Bremen (Germany),
University of British Columbia (UBC), Cardiff
University (Wales), University College Dublin
(UCD, Ireland), and Universitat Rovira i Virgili
in Spain (URV).
This material is based upon work supported by the
National Science Foundation and the Environmental
Protection Agency under Cooperative Agreement
Number EF 0830117. Any opinions, findings, and
conclusions or recommendations expressed in this
material are those of the author(s) and do not
necessarily reflect the views of the National
Science Foundation or the Environmental
Protection Agency. This work has not been
subjected to EPA review and no official
endorsement should be inferred.