Chapter 12 (part 1)

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Chapter 12 (part 1)

• Citric Acid Cycle

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Gylcolysis
Electron Transport and Oxidative phosphorylation
TCA Cycle
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Entry into the TCA Cycle
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Pyruvate Dehydrogenase
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Citrate Synthase

• Only step in TCA cycle that involves the
  formation of a C-C bond

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Aconitase
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Isocitrate Dehydrogenase
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? -Ketoglutarate Dehydrogenase
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Succinyl-CoA Synthetase
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Fumarase
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Malate Dehydrogenase
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Reduced Coenzymes Fuel ATP Production

• Acetyl-CoA 3 NAD Q GDP Pi 2 H20 ?
  HS-CoA 3NADH QH2 GTP 2 CO2 2 H
• Isocitrate Dehydrogenase 1 NADH2.5 ATP
• a-ketoglutarate dehydrogenase 1 NADH2.5 ATP
• Succinyl-CoA synthetase 1 GTP1 ATP
• Sunccinate dehydrogenase 1 QH21.5 ATP
• Malate Dehydrogenase 1 NADH2.5 ATP
• Total of 10 ATPs gained from oxidation of 1
  Acetyl-CoA

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Regulation of TCA Cycle
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Protein/amino acid Catabolites feed Into the TCA
Cycle
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Fats breakdown and feed into the TCA Cycle
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TCA Cycle provides intermediates for many
biosynthetic processes
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The Anaplerotic Reactions

• The "filling up" reactions
• PEP carboxylase - converts PEP to oxaloacetate
• Pyruvate carboxylase - converts pyruvate to
  oxaloacetate
• Malic enzyme converts pyruvate into malate

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Following the carbons through the TCA cycle
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