GHB

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NIDA Clinical Trials Network
Bridging the Gap
Research Practice
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The Problem
T2
T1
Bench
Bedside
Practice
The CTN
Participatory model to engage practitioners
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National Drug Abuse Treatment
Clinical Trials Network
A research infrastructure of 16 RRTCs 200 CTPs
across 34 States, and Puerto Rico
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CTNs Mission
To Improve Drug Abuse Treatment Throughout the
Nation Using SCIENCE as the Vehicle
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The Drug Abuse Treatment Community
Rehab Centers Betty Ford Center Hazelden
Foundation Caron Foundation
Hospitals Kaiser Permanente VA Hospitals Mayo
Clinic Mercy Hospital RWJ Medical Center
Therapeutic Community Odyssey House Center for
Drug-Free Living Walden House, Phoenix House
NaNizhoozi Center Homeward Bound
Methadone Clinics Evergreen Treatment
Services Addiction Research Treatment
Corp. Bi-Valley Medical Clinic Hartford
Dispensary
Social Model Behavioral Model
Medical Model
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The CTN Trials (1999 now)
Medications 9 Behavioral Interventions
13 HIV/HCV Interventions 5 Others 3
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Current CTN Portfolio (21 Protocols) By
Intervention Type
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CTN
Since 1999, we have established

• Partnership between Researchers and Practitioners
• A forum for blending research and practice
• A platform for bi-directional communication

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CTN Steering Committee Organization
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Generation of Research Concepts
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CTN Special Interest Groups The Brain Trust

• Groups
• HIV/AIDS
• Adolescent
• Women and Gender
• Co-Morbidity
• Court-Involved Patients
• Ethnic Minority
• Behavioral Therapy
• Pharmacological Therapy
• Treatment Matching
• Smoking
• Homelessness
• Spirituality
• Alcohol

• Tasks
• Generate snapshots of current practice
• Identify empirically supported interventions
• Develop research concepts
• Identify and develop special research tools
• Develop long range research plan
• Serve as expert resources

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The CTN Platform

• Ancillary and/or stand alone studies
• health service/genetics / training methods/
  Psychometric studies from various NIDA Divisions
  (31) and NIAAA (1)
• SBIR/STTR (5)
• Secondary analysis on rich database
• Minority pre-doc/post doc training (10)
• NIDA INVEST Scholars international (3)
• K12 training platform (50)
• CTN training networks

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Todays Challenges

• Integrating drug abuse treatment into mainstream
  medical practice

• Psychiatric Comorbidity
• ADHD / SUD
• PTSD / SUD
• Anxiety / SUD
• Depression / SUD

• Chronic Illness Comorbidity
• Pain / SUD
• HIV / SUD
• HCV / SUD

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The CTN Dissemination Libraryhttp//ctndisseminat
ionlibrary.org

• Housed and maintained by Washington Node
• Single point of access to all CTN materials
  approved for public sharing
• Protocols, tools, publications, blending products
• Training schedules, future meeting dates, etc.

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Partnerships Are Essential In Advancing the
Science of Addiction and in Translating
Promising Strategies into Practice
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NIDA-SAMHSA Blending Teams
Motivational Interviewing Assessment
Supervisory Tools for Enhancing Proficiency
(MIA-STEP)
Promoting Awareness of Motivational
Incentives (PAMI)

• Buprenorphine Treatment A Training for
  Multidisciplinary Addiction Professionals

Short-Term Opioid Withdrawal Using
Buprenorphine

• Treatment Planning MATRS Utilizing the
  Addiction Severity Index (ASI) to Make Required
  Data Collection Useful

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CTN Data Sharing http//www.ctndatashare.org

• Secondary analysis on rich database
• CTN 0001, 0002, 0004, 0005, 0006, 0007, 0008,
  0009, 0011, 0012, 0016

• CDISC standardized
• HIPAA Compliant
• CTN Public data/documents include
• Data sets (SAS and ASCII)
• Defined file (aka data dictionary)
• Annotated Case Report Forms
• Study protocol and reference to study publication
  of primary outcomes

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www.nida.nih.gov/CTN/Index.htm
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Pharmacological Therapies

• Buprenorphine/Naloxone (Suboxone)
• Bup/Nx vs Clonidine in detox
• Bup/Nx vs Methadone (liver function)
• Bup/Nx for adolescents
• Bup/Nx for prescription opiate dependence
• Osmotic-Release Methylphenidate (Concerta)
• Adult smokers with ADHD
• Adolescent substance users with ADHD
• Nicotine replacement in drug treatment

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Behavioral Therapies

• (MI or CM) Lower cost motivational incentives
• (MI/MET) Motivational interviewing enhancement
• Adults pregnant women Spanish speakers
• Seeking Safety trauma counseling for women
• Reducing HIV/HCV risk behavior
• Injection drug use sex risks for women men
• Job Seekers vocational training Native Americans
• Brief Strategic Family Therapy adolescents
• Counselor feedback
• Telephone Enhancement to Improve Aftercare