ORGANISATION DE LA CHROMATINE

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ORGANISATION DE LA CHROMATINE Timothy
Reudelhuber IRCM 987-5716
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2.8 A crystal structure of the Mono-nucleosome
From Luger et al Nature 389 251 - 260 (1997)
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Histone tail interactions with DNA
From Luger et al Nature 389 251 - 260 (1997)
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Histone assemble in Pairs and tails can be
modified
methyl
acetyl
From Grewal and Moazed Science 301798-802 (2003)
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From Jaskelioff and Peterson Nature Cell Biol
5395-399 (2003)
way modified!
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From Horn and Peterson Science 2971824 (2003)
Chromatin exists in domains
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A model for propagation Of chromatin repression
From Grewal and Moazed Science 301798-802 (2003)
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Two types of chromatin-silencing
complexes Mediated by protein or small RNAs
From Grewal and Moazed Science 301798-802 (2003)
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Models to explain the role Of RNA transcripts
in Silencing chromatin
From Grewal and Moazed Science 301798-802 (2003)
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From Haushalter and Kadonaga Nature Reviews Mol
Cell Biol 4613-620 (2003)
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From Haushalter and Kadonaga Nature Reviews Mol
Cell Biol 4613-620 (2003)
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From Haushalter and Kadonaga Nature Reviews Mol
Cell Biol 4613-620 (2003)
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From Haushalter and Kadonaga Nature Reviews Mol
Cell Biol 4613-620 (2003)
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Various models to explain association of
chromatin remodeling complexes
Recognition of a transcription factor
Recognition of methylated DNA
Binding at the nuclear envelope
Binding to acetylated histones
From Becker and Horz Annu Rev Biochem 71
247-273 (2002)
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How do chromatin remodeling complexes work?
From Becker and Horz Annu Rev Biochem 71
247-273 (2002)
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Real examples of CRMs in action
Interferon gene
HO gene
From Becker and Horz Annu Rev Biochem 71
247-273 (2002)
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CRMs and nuclear receptors
From Belandia and Parker Cell 114 277-280 (2003)
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Proposed mechanisms for Transcription-linked
nucleosome Displacement by FACT/spt6
Svejstrup J.Q. Science. 3011053-1055 (2003)