Erythropoiesis

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Erythropoiesis

• Yuttana Mundee
• Clinical Microscopy
• Associated Medical Science
• Chiang Mai University
• yuttana_at_mail.ams.cmu.ac.th

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Peripheral Blood
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Whole Blood
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Hemopoiesis
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Myeloid Lineage
Erythroid Lineage
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Erythropoiesis

• Formation or making of red blood cells
• Life-span 120 days
• New-born old-death 1 - 1.5
• Bone marrow gt macrophages (RE cells)
• Fe, Proteins (amino acids), B12, Folate, etc.

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Erythropoiesis
Erythron
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Blood Forming Organs

• Mesoblastic period
• yolk sac
• Hepatic period
• liver spleen
• Myeloid period
• bone marrow (BM)

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Blood Forming Organs (cont.)

• Medullary Hemopoiesis
• bone marrow (BM)
• Extramedullary Hemopoiesis
• liver / spleen

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Blood Forming Organs
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Stages of Erythron
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(No Transcript)
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E2
E1
E3
E3
E5
E4
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Extrusion
Polychromasia
Reticulocytes
Erythrocytes
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Erythropoiesis Mechanism

• Proliferation
• Differentiation
• Maturation
• Release
• Functional RBC
• Senile RBC

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Erythropoiesis Mechanism
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Characteristic of Erythron
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Bone Marrow Structure
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Bone Marrow Section
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Bone Marrow Contour
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Normal Red Blood Cells
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Functional Blood Cells
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Regulation of Erythropoiesis

• Hypoxia
• Oxygen tension in blood
• Peritubular cells in Kidney
• Erythropoietin
• Nutrients raw materials

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Regulation of Erythropoiesis
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Erythropoietin (Epo)

• Chromosome 7 (q)
• 3000 kDa
• 165 Amino acids
• 60 Proteins
• 40 Carbohydrate
• Peritubular cells in Kidney

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Molecule of Erythropoietin
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Factors Effecting Erythropoiesis

• Micro-environment
• Stem cells
• Nutrients / Erythropoietin / Etc.