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Immunology

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Calor, Dolor, Edema, Erythema. Inflammation. Vasodilatation. Histamine. Kinins. Prostaglandins ... Interact with CHO on microbes surface. Some have interior ... – PowerPoint PPT presentation

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Title: Immunology


1
Immunology
  • Pathogens
  • Virus
  • Bacteria
  • Fungi
  • Protozoan
  • Parasitic worms
  • Toxins
  • Environmental conditions

2
Nonspecific
  • Skin
  • Mucus
  • Sebum
  • Gastric juice
  • perspiration
  • Tears
  • Urine
  • Diarrhea
  • Enzymes
  • Normal Flora

3
Inflammation
  • Leukocytes
  • Neutrophils
  • Eosinophils
  • Basophils
  • Macrophages
  • Blood clotting factors
  • Lymph nodes
  • Calor, Dolor, Edema, Erythema

4
Inflammation
  • Vasodilatation
  • Histamine
  • Kinins
  • Prostaglandins
  • Function
  • Fever
  • 37 degrees
  • Hypothalamus
  • Interleukin 1
  • Prostaglandins
  • Chill and Crisis

5
  • Fever
  • Hostile environment for pathogens
  • Increase metabolic rate

6
Complement System
  • Plasma proteins
  • Specific and nonspecific
  • Activated by antibody-antigen complex
  • Interact with CHO on microbes surface
  • Some have interior channels that lyse pathogen
    (pore)

7
  • Complement cascade create gradients that attract
    more wbc
  • Netrophils - bact
  • Eosinophils - worms
  • Basophils - allergy

8
Immune System
  • Immune response characterized by immunological
    specificity and memory
  • B and T cells

9
  • T cells
  • Recognize self and non-self
  • Major histocompatibility markers (MHC)
  • Function
  • 1. Recognition
  • 2. Cell division
  • 3. Differentiation

10
  • B cells
  • Activated by T helper cells
  • Differentiation into plasma cells and memory
    cells
  • Plasma cells
  • Produce antibodies for immediate attack
  • Memory cells
  • For next attack
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