Pharmacokinetics Analysis | PumasAI

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PHARMACOKINETICS ANALYSIS
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Pharmacokinetics, the study of drug movement in
the body, delves deeply into the mechanisms of
drug absorption, shedding light on how
medications are absorbed, distributed,
metabolized, and excreted.
Among these processes, drug absorption stands as
a crucial initial step, dictating the onset and
intensity of therapeutic effects. Understanding
the complexities of drug absorption through a
pharmacokinetic lens elucidates the factors
influencing this pivotal phase.
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The journey of a drug starts with its
physicochemical attributes. Factors like
solubility, molecular weight, and polarity
determine its ability to permeate biological
barriers. Lipophilic substances, for instance,
can easily traverse lipid-rich membranes,
expediting absorption into systemic circulation.
Drug absorption varies with administration
routes. Oral intake, the most common route,
undergoes intricate processes, encountering
barriers like gastrointestinal fluids and
enzymatic degradation. Alternatively, intravenous
administration bypasses barriers, ensuring rapid
and complete drug absorption.
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The gastrointestinal tract primarily serves as
the absorption site for orally administered
drugs. Variation in pH, surface area, and blood
flow across different segments influences drug
absorption rates. The small intestine, rich in
absorptive surface, facilitates optimal drug
uptake due to its vast microvilli-covered surface
area.
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