Pomalidomide Pomalid 4mg | Anticancerdrugs | MHP

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Pomalidomide Pomalid 4mg Anticancerdrugs MHP
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POMALID 4MG DEFINE

• Pomalidomide is sold under the brand name Pomalid
  4mg and it belongs to anti neoplastics drugs 
• Pomalid 4mg is doable as orally bioavailable
  thalidomide derivative asssociated with numerous
  therapeutic activities such as immune
  modulatory, anti-angiogenesis, anti neoplastic.
  Pomalid 4mg combination with dexamethasone will
  cause liver injury

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POMALID 4MG CLINICAL USE

• The primary indication of Pomalid 4mg tablet is
  used in the treatment of Multiple Myeloma
  condition. In this condition, Pomalid 4mg is used
  by combining with dexamethasone. Pomalid 4mg
  capsules are applicable in Previously the
  Patients treated with two treatment such as
  proteasome inhibitor Lenalidomide. Patients who
  are suffered with disease progression condition
  Pomalid 4mg TABLET treatment should be followed
  within 60 days in patients who are concluded the
  last treatment.

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POMALID 4MG WORKS AS

• Pomalid 4MG has three primary pharmacological
  activities against cancer cells. Pomalidomide
  includes in the way cancer proliferation and
  provoke the apoptosis of cancer cells.
  Pomalidomide enhance the T cell natural killer
  cells interceding immunity inhibits the
  formation of pro inflammatory cytokines from
  monocytes. Pomalidomide forbid the new cell
  formation. The binding of Pomalidomide to active
  site of targeted cell causes inhibition of
  ubiquitin ligase action.

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ADME PROPERTIES

• The time to high serum concentration of
  Pomalidomide is reaches between 2 to 3 hours. It
  should be administered with or without food.
  Hence No effect of food should be produced
  Volume of distribution of Pomalidomide is between
  62 138L in steady state.
• The Pomalidomide distribution by 67 of serum
  level at after 4 hours of drug intake. human
  plasma protein by bounding range of 12 44.
  Hepatically mediated through CYP1A2, CYP3A4 is
  Pomalidomide is metabolized.

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ADME PROPERTIES

• Pomalidomide clearance value is 7 to 10L/hr.
  Doses are excreted via urine 73 feces 15
  respectively. Doses are excreted as an unchanged
  form via urine 2 feces 8. Pomalidomide half
  life period is 9.5 hours.

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Pomalid 4mg

• Brand  Pomalid
• Ingredients  Pomalidomide
• Strength  4mg
• Manufactured  Natco
• Package  21 TabletsDURING MULTIPLE MYELOMA
  MALIGNANCIES

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Dosage Management

• DURING MULTIPLE MYELOMA MALIGNANCIES
• The dosage recommendation of Pomalid 4mg is 4mg
  should be administered as a single dose for 1 to
  21 days of successive 28 day cycles. Pomalid is
  combined with dexamethasone with low dose.
  Administrate Dexamethasone on day 1, 8, 15 22
  of each 28 day cycle. The prescribed dose of
  dexamethasone is 40mg should be administered the
  patient having weight about 75kg. The
  prescribed dose of dexamethasone is 20mg given
  for patients weight Greater than 75kg

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Dosage Management

• DOSAGE ALTERATION DURING HEMATOLOGICAL
  TOXICITIES NEUTROPENIAANC
• lt500/mcL Pomalid treatment should be postponed
  and check the CBC weekly. ANC 500/mcL Pomalid
  therapy should be continued by 3mg/day For each
  successive drop lt500/mcL Pomalid 4mg should be
  postponed. ANC 500/mcL Continue the Pomalid
  therapy with 1mg/day.

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Dosage Management

• THROMBOCYTOPENIA
• Platelets count lt25000/mcL Pomalid therapy
  should be postponed and check CBC Platelets count
  50000/mcL 3mg of Pomalid should be taken daily

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Dosage Management

• WITH STRONG CYP1A2
• Pomalid combined with CYP1A2 substrates causes
  increasing the plasma concentration of
  Pomalidomide and leads to elevate the risk of
  Pomalidomide.

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Dosage Management

• IN RENAL DAMAGED PATIENTS
• In severe renal impaired patients, the suggested
  dose of Pomalid is 3mg per day.

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Dosage Management

• IN HEPATIC IMPAIRED PATIENTS
• The advised dose is 3mg/day in severe
  condition, the suggested dose is 2mg/day given
  for mild to moderate patients.

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POMALID 4MG DRUG INTERACTION

• POMALID 4MG DRUG INTERACTION
• Pomalid 4mg concurrently used with CYP1A2 drugs
  causes increased concentration of Pomalidomide.
  Overcome this problem by reducing the dose
  of Pomalid 4mg during this combination
  therapy.POMALID 4MG CONTRAINDICATION
• Pomalid 4mg is contraindicated to Pregnancy
  Lactation Hypersensitivity reactions produced due
  to patients are contraindicated to the component
  of Pomalid 4mg .POMALID 4MG WARNING
• The most probable worsening condition of Pomalid
  4mg tablet is Venous arterial thromboembolism
  Embryo fetal damage

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