EVERMIL 10MG TABLET | EVEROLIMUS | MHP

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EVERMIL 10MG TABLET EVEROLIMUS MHP

• Million Health Pharmaceuticals

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DESCRIPTION

• Evermil 10mg is a derivative of Rapamycin
  (sirolimus) and works similarly to Rapamycin as
  an mTOR (mammalian target of rapamycin)
  inhibitor.It is normally used as an
  immunosuppressant to prevent rejection of organ
  transplants. In a similar fashion to other mTOR
  inhibitors Everolimus' effect is solely on the
  mTORC1 protein and not on the mTORC2 protein.

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Brain carcinoma
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PRESCRIBING INFORMATION

• Evermil 10mg tablet are mainly indicated for the
  treatment of Renal carcinoma.Evermil 10mg  are
  mainly indicated for the treatment of Breast
  carcinoma.Evermil 10mg tablet are mainly
  indicated for the treatment of Brain
  carcinoma.Evermil 10mg is also used in various
  advanced stage cancer in stomach, intestines or
  pancreas.

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MECHANISM OF ACTION

• Everolimus is an mTOR prohibitor, joints at high
  compatibility to FK506 binding protein 12, via
  producing drug complex which inhibits the
  specific of mTOR.This inhibition decreases the
  activity of effectors downstream, that may cause
  blockage of cell progression from G1 into S
  phase, subsequently causes cell growth arrest and
  apoptosis

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PRODUCT DETAILS

• Brand Evermil Ingredients Everolimus Strengt
  h 5mgManufactured Glenmark
  pharmaceuticals Package 10 tablets 

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PHARMACOKINETIC

• ABSORPTION
• The high plasma concentration time of Everolimus
  is 1 to 2 hours.The effect of food with Evermil
  10mg that with heavy meal Reduction of systemic
  exposure to Evermil 5mg 10mg, and the high blood
  plasma concentration by 54.DISTRIBUTION
• Evermil 10mg human plasma protein bound with the
  range of 74.METABOLISM
• The metabolism of Everolimus is occurred in
  liver, which is a substrate of CYP3A4.The
  metabolites of Everolimus

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DOSAGE MANAGEMENT

• In breast cancer, renal cell cancer, pancreatic
  cancer, Neuro endocrine cancerThe prescribed
  dosage is 10mg should be taken as a single
  dose.In Brain or intracranial cancerThe
  prescribed dosage of Evermil 10mg tablet is
  4.5mg/m2 orally as a single dose.In
  pediatricThe usual pediatric dosage of Evermil
  10mg in brain or intracranial tumor is 4.5mg/m2
  should be taken orally as a single dose. Evermil
  10mg tablet should be administered with or
  without food.

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PRECAUTIONS

• Lymphomas
• Increased exposure of skin cancers, patient may
  protect from UV lightSerious infections
• Patients receiving Evermil 10mg have high risk of
  acquiring various infections related to bacteria,
  virus, and fungi. Anti-microbial agents are
  preferred for the suspected patients.Hepatic
  artery thrombosis
• In liver transplant patients, Evermil
  10mg therapy should not be recommended. Nephrotox
  icity
• Renal function should be monitored frequently
  caution should be taken while usingEvermil
  10mg in renal impaired patients. 

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SIDE EFFECTS

• Hypersensitivity reactions Lymphomas other
  malignancy Serious infections Kidney graft
  thrombosis Hepatic artery thrombosis
  Nephrotoxicity Hyperlipemia Angioedema
  Interstitial lung disease Thrombocytopenia
  Male infertility Proteinuria New commencement
  of diabetes .

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CONTRAINDICATIONS

• Some anaphylactic reaction occurs, if patients
  are contraindicated to the components present in
  the Evermil 10mg tablet.

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PREGNANCY

• Pregnancy category C Evermil 10mg is needed only
  by the patients after knowing the benefits to the
  mother outweighs the risk to fetus.

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STORAGE

• Evermil 10mg tablet should be kept at 25CKeep
  the tablet away from moisture, heat and
  lightDispense only in original container.

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MISSED DOSE

• If patient failed to take a single dose, patients
  must consult with medical practitioner and follow
  the instructions given by them. Or the missed
  dose should be avoiding and follow the regular
  dosing schedule.

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• OVERDOSAGE
• The over dosage of Everolimus is rarely occur, in
  case of over dosage patient must be provide with
  supportive measures. The acute toxicity of
  Everolimus over dosage should be monitored.

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CONTACT US

• PHONE NO91-9940472902
• E-MAILmillionhealthpharmaceuticals_at_gmail.com
• WEBSITE URLhttps//millionpharma.com/evermil-10-m
  g.php