EVERTOR 5MG TABLETS | EVEROLIMUS | MHP

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EVERTOR 5MG TABLETS EVEROLIMUS MHP

• Million Health Pharmaceuticals

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DESCRIPITION

• Evertor 5mg is a derivative of Rapamycin
  (sirolimus) and works similarly to Rapamycin as
  an mTOR (mammalian target of rapamycin)
  inhibitor.It is normally used as an
  immunosuppressant to prevent rejection of organ
  transplants.In a similar fashion to other mTOR
  inhibitors Everolimus' effect is solely on the
  mTORC1 protein and not on the mTORC2 protein.

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Brain carcinoma
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PRESCRIBING INFORMATION

• Evertor 5mg tablets are mainly indicated for the
  treatment of Renal carcinoma.
• Evertor 5mg tablets are mainly indicated for the
  treatment of Breast carcinoma.
• Evertor 5mg tablets are mainly indicated for the
  treatment of Brain carcinoma.
• Evertor 5mg is also used in various advanced
  stage cancer in stomach, intestines or pancreas 

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MECHANISM OF ACTION

• Everolimus is an mTOR prohibitor, joints at high
  compatibility to FK506 binding protein 12, via
  producing drug complex whichinhibits the specific
  of mTOR.
• This inhibition decreases the activity of
  effectors downstream, that may cause blockage of
  cell progression from G1 into S phase,
  subsequently causes cell growth arrest and
  apoptosis

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PRODUCT DETAILS

• Brand EvertorIngredients Everolimus Strength
  5MGManufactured Biocon Pharma Package 10
  tablets 

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PHARMACOKINETICS

• ABSORPTION
• The high plasma concentration time of Everolimus
  is 1 to 2 hours.
• The effect of food with Evertor 5mg that with
  heavy meal Reduction of systemic exposure
  to Evertor 5mg10mg, and the high blood plasma
  concentration by 54.
• DISTRIBUTION
• Evertor 5mg human plasma protein bound with the
  range of 74.80 ml/kg
• METABOLISM
• The metabolism of Everolimus is occurred in
  liver, which is a substrate of CYP3A4.

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DOSAGE MANAGEMENT

• In breast cancer, renal cell cancer, pancreatic
  cancer, Neuro endocrine cancerThe prescribed
  dosage is 10mg should be taken as a single
  dose.In Brain or intracranial cancerThe
  prescribed dosage of Evertor is 4.5mg/m2 orally
  as a single dose.In pediatricThe usual
  pediatric dosage of Evertor in brain or
  intracranial tumor is 4.5mg/m2 should be taken
  orally as a single dose.

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PRECAUTIONS

• Lymphomas Increased exposure of skin cancers,
  patient may protect from UV lightSerious
  infections Patients receiving Evertor 5mg have
  high risk of acquiring various infections related
  to bacteria, virus, and fungi.Anti-microbial
  agents are preferred for the suspected
  patients.Hepatic artery thrombosis In liver
  transplant patients, Evertor 5mg therapy should
  not be recommended.

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SIDE EFFECTS

• Hypersensitivity reactions Lymphomas other
  malignancy Serious infections Kidney graft
  thrombosis Hepatic artery thrombosis
  Nephrotoxicity Hyperlipemia Angioedema
  Interstitial lung disease Thrombocytopenia
  Male infertility Proteinuria New commencement
  of diabetes.

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DRUG INTERACTION

•  Evertor 5mg interaction with strong inhibitor
  of CYP3A4, or P-gp, leads to cause decreasing the
  efflux of Everolimus and increase the plasma
  concentration of Everolimus Combination
  of Evertor 5mg with verapamil leads to increasing
  the plasma concentration of Everolimus.
  Combination of Evertor 5mg with Atorvastatin or
  pravastatin causes rhabdomyolysis, due to
  increasing concentration of lipid lowering
  agents. Evertor 5mg combination with strong
  CYP3A4 inducers, causes increasing the exposure
  of Everolimus. Concomitant use of Evertor
  5mg with cyclosporine causes increasing the AUC
  level of Everolimus frequently. Evertor
  5mg tablet is interaction with ketoconazole or
  other CYP3A4 inhibitors causes increasing the
  plasma concentration and AUC of Everolimus.

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CONTRAINDICATIONS

• Some anaphylactic reaction occurs, if patients
  are contraindicated to the components present in
  the Evertor 5mg tablets.

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PREGNANCY

• Pregnancy category C Evertor 5mg is needed only
  by the patients after knowing the benefits to the
  mother outweighs the risk to fetus.

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STORAGE

• Evertor 5mg tablet should be kept at 25C
• Keep the tablet away from moisture, heat and
  lightDispense only in original container

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MISSED DOSE

• If patient failed to take a single dose, patients
  must consult with medical practitioner and follow
  the instructions given by them.
• Or the missed dose should be avoiding and follow
  the regular dosing schedule.

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OVERDOSAGE

• The over dosage of Everolimus is rarely occur, in
  case of over dosage patient must be provide with
  supportive measures. The acute toxicity of
  Everolimus over dosage should be monitored.

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CONTACT US

• MOBILE NO 91-9940472902
• EMAIL   millionhealthpharmaceuticals_at_gmail.com
• WEBSITEURL https//millionpharma.com/evertor-5-mg
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