Primary Biliary Cholangitis: Causes, Symptoms, Daignosis, Prevention and Treatment

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Primary Biliary Cholangitis
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Primary Biliary Cholangitis

• Primary biliary cholangitis is a rare disease in
  which the bile ducts become progressively
  inflamed and destroyed. Bile builds up in the
  liver (cholestasis), causing fibrosis and
  cirrhosis of the liver.Primary biliary
  cholangitis is somehow different from secondary
  biliary cholangitis, in which the bile ducts are
  obstructed or damaged due to another cause like a
  tumor.

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Causes of Primary Biliary Cholangitis

• The cause of primary biliary cholangitis is not
  fully understood but is considered as an
  autoimmune disease, in which the immune system
  attacks the bodys bile duct cells.Some experts
  believe that primary biliary cholangitis can be
  triggered by a fungal, bacterial, or parasitic
  infection.Women are 9 times more likely than men
  to develop primary biliary cholangitis.Serious
  complications of primary biliary cholangitis
  include
• Cirrhosis of the liver
• Portal hypertension

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Causes of Primary Biliary Cholangitis
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• Varices (enlarged veins in the esophagus and
  stomach that are susceptible to life-threatening
  bleeding)
• Osteoporosis
• Liver cancer

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Symptoms of primary biliary cholangitis

• Some patients experience none of the symptoms,
  while others may experience symptoms like
• Fatigue
• Itchy skin
• Abdominal pain
• Dry eyes
• Dry mouth
• Yellowing of the skin and eyes (jaundice)
• Darkening of the skin
• Swollen feet and ankles

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Symptoms of primary biliary cholangitis
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• Accumulation of abdominal fluid (ascites)
• Greasy diarrhea
• Memory problems
• Vitamin deficiencies

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Treatments for Primary Biliary Cholangitis

• There is no cure for primary biliary
  cholangitis, so treatments are aimed at slowing
  the progression of disease, relieving symptoms,
  and preventing complications.MedicationsMedicat
  ions are used to reduce cholestasis, improve
  liver function, relieve itching and fatigue, and
  to treat complications like varices and
  osteoporosis. The first line of treatment is
  Ursodeoxycholic acid (UDCA), also known as
  ursodiol (Actigall, Urso). Medication and surgery
  for portal hypertension may also be
  needed.Liver TransplantIf medical therapies no
  longer control symptoms and the liver begins to
  fail, liver transplantation may be considered.
  Primary biliary cholangitis can recur in the new
  liver after some years.

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